Comparable serum salicylate concentrations from choline magnesium trisalicylate, aspirin, and buffered aspirin in rheumatoid arthritis

Binus, Mark H.; Lyon, James A.; Nicholas, Johann

doi:10.1002/art.1780250418

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…In our subjects, the one week administration of 3,000 mg CMr daily raised serum salicylate concentrations to similar levels to those reported for patients with rheumatoid arthritis [19], which are known to decrease the inflammatory symptoms in that disease. CMT did not provoke any adverse effects in the respiratory tract or any other severe side-effects.…”

Section: Removal Of P(je 2 By Cyclooxygenase Inhibitorssupporting

confidence: 85%

Choline magnesium trisalicylate in patients with aspirin-induced asthma

Szczeklik¹,

Nizankowska²,

Dworski³

1990

Eur Respir J

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Treatment of inflammatory diseases of asthmatics can be a serious problem since some patients show intolerance to aspirin and other non-steroidal, anti-inflammatory drugs that are cyclooxygenase inhibitors. Salicylates were believed to be well tolerated, but recent reports have demonstrated that diflunisal and salicylsalicylic acid can precipitate asthma attacks in aspirin-intolerant patients. This study was designed to determine the tolerance of choline magnesium trisalicylate (CMT), a nonacetylated salicylate with potent analgesic and anti-inflammatory activity, in 23 asthmatics with aspirin hypersensitivity confirmed by oral challenge. The study consisted of three phases: 1) patients received increasing doses (50-1,500 mg) of CMT under a single-blind protocol; 2) patients received either a placebo or CMT challenge in a double-blind, randomized, cross-over design; 3) patients received CMT at daily 3,000 mg doses for 1 week. Throughout the study, pulmonary function tests, peak nasal inspiratory flow, and serum salicylate and thromboxane B2 (TXB2) levels were monitored. Results showed no airway obstruction, nasal congestion or rhinorrhea after CMT. There was no significant decrease in serum TXB2 levels, indicating the absence of cyclooxygenase inhibition with CMT. We conclude that choline magnesium trisalicylate is a safe drug for treatment of different anti-inflammatory disorders in asthmatics with aspirin hypersensitivity.

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Section: Removal Of P(je 2 By Cyclooxygenase Inhibitorssupporting

confidence: 85%

Choline magnesium trisalicylate in patients with aspirin-induced asthma

Szczeklik¹,

Nizankowska²,

Dworski³

1990

Eur Respir J

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“…Studies in adult patients have shown that serum salicylate concentrations and salicylates elimination rates are equivalent to those reported for aspirin. 5,6 It has also been demonstrated that serum salicylate concentrations are comparable in febrile children given aspirin given choline salicylate and aspirin. 7 All of the available medical and pharmacology literature supports the successful use of choline magnesium trisalicylate in pediatric patients.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Acute Rheumatic Carditis with Choline Magnesium Trisalicylate in a Patient Needing Surgery

Moffett

Arora

Bricker

2003

The Journal of Pediatric Pharmacology and Therapeutics

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Acute rheumatic fever is a post-infectious illness characterized by diffuse inflammation. Typically, high-dose anti-inflammatory agents are used as primary therapy for this disorder. In addition to their anti-inflammatory properties, these agents, most frequently aspirin, also have anti-platelet properties. We describe the case of an 11-year-old patient with rheumatic fever who needed to undergo surgery. The use of traditional anti-inflammatory agents would have posed a potential problem with postsurgical bleeding, so a lesser-used anti-inflammatory agent (i.e., choline magnesium trisalicylate) was selected.KEYWORDS: acute rheumatic carditis, anti-inflammatory, choline magnesium trisalicylate, pediatric, Trilisate 2003;8:284-6 An 11-year-old male with a history of Trisomy 21 and obesity presented to our hospital with complaints of shortness of breath and tachypnea. He had no known history of congenital heart disease. On review of systems, he had a 1-month history of arthralgias but did not have any history of fever or sore throat. In addition, he had a prolonged history of loud breathing during sleep and occasional apnea. His vital signs were notable for mild desaturation with a room air oxygen saturation of 88%. J Pediatr Pharmacol TherHis physical examination was remarkable for facies consistent with Trisomy 21, obesity, tonsillar hypertrophy, diminished breath sounds at his lung bases bilaterally, and quiet heart sounds with an intermittent III/VI holosystolic murmur heard best at the apex. There were no diastolic murmurs. His liver edge was palpable approximately 3-4 cm below the right costal margin. His chest radiograph showed an enlarged cardiac silhouette, bilateral pleural effusions, and increased pulmonary vascular markings. His laboratory studies were remarkable for an elevated erythrocyte sedimentation rate (ESR) of 106 mm/ hour (nl=0-20 mm/hour), an elevated C-reactive protein of 8.4 mg/dL (nl=0-1 mg/dL), and an elevated antistreptolysin (ASO) of 400 IU/mL (nl <250 IU/mL). An echocardiogram performed showed normal intracardiac anatomy with severe aortic regurgitation, moderate mitral regurgitation, no evidence of vegetations, a dilated left atrium and left ventricle, and good left ventricular function. His left ventricular shortening fraction was 41%, and he had qualitatively good right ventricular function.He met the criteria for acute rheumatic fever (major criteria = carditis, 2 minor criteria = elevated ESR and history of arthralgias, and evidence of recent streptococcal infection = elevated ASO).

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Saure antipyretische Analgetika

Waldvogel¹

2001

Analgetika Antinozizeptiva Adjuvanzien

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Comparable serum salicylate concentrations from choline magnesium trisalicylate, aspirin, and buffered aspirin in rheumatoid arthritis

Cited by 6 publications

References 6 publications

Choline magnesium trisalicylate in patients with aspirin-induced asthma

Choline magnesium trisalicylate in patients with aspirin-induced asthma

Treatment of Acute Rheumatic Carditis with Choline Magnesium Trisalicylate in a Patient Needing Surgery

Saure antipyretische Analgetika

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