Comparable mechanisms of working memory interference by auditory and visual motion in youth and aging

Mishra, Jyoti; Zanto, Theodore P.; Nilakantan, Aneesha S.; Gazzaley, Adam

doi:10.1016/j.neuropsychologia.2013.06.011

Cited by 22 publications

(33 citation statements)

References 67 publications

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“…For example, we did not find a greater impact of distractions and interruptions in the auditory modality in older relative to younger adults (Mishra et al, 2013). Older adults also perform equivalently to younger adults in a multisensory setting, even when the audiovisual stimulus content is incongruent/conflicting across the two sensory domains (Mishra and Gazzaley, 2013).…”

Section: External Interference Resolution Across the Lifespancontrasting

confidence: 64%

“…In contrast, neural activity to interruptions, which served as stimuli for a secondary discrimination task, was enhanced. Recently, we replicated these findings for intrasensory interference during auditory WM (Mishra et al, 2013). Using fMRI-based functional connectivity analyses, Clapp et al (2011) further revealed that at the onset of interruptions, connectivity in a visual (visual association cortex, VAC)–prefrontal (middle frontal gyrus, MFG) memory maintenance network was disrupted and dynamically reallocated to the attended interruptor.…”

Section: External Interference Resolution Across the Lifespansupporting

confidence: 57%

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A Cognitive Framework for Understanding and Improving Interference Resolution in the Brain

Mishra

Anguera

Ziegler

et al. 2013

Progress in Brain Research

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All of us are familiar with the negative impact of interference on achieving our task goals. We are referring to interference by information, which either impinges on our senses from an external environmental source or is internally generated by our thoughts. Informed by more than a decade of research on the cognitive and neural processing of interference, we have developed a framework for understanding how interference impacts our neural systems and especially how it is regulated and suppressed during efficient on-task performance. Importantly, externally and internally generated interferences have distinct neural signatures, and further, distinct neural processing emerges depending on whether individuals must ignore and suppress the interference, as for distractions, or engage with them in a secondary task, as during multitasking. Here, we elaborate on this cognitive framework and how it changes throughout the human lifespan, focusing mostly on research evidence from younger adults and comparing these findings to data from older adults, children, and cognitively impaired populations. With insights gleaned from our growing understanding, we then describe three novel translational efforts in our lab directed at improving distinct aspects of interference resolution using cognitive training. Critically, these training approaches were specifically developed to target improved interference resolution based on neuroplasticity principles and have shown much success in randomized controlled first version evaluations in healthy aging. Our results show not only on-task training improvements but also robust generalization of benefit to other cognitive control abilities. This research showcases how an in-depth understanding of neural mechanisms can then inform the development of effective deficit-targeted interventions, which can in turn benefit both healthy and cognitively impaired populations.

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Section: External Interference Resolution Across the Lifespancontrasting

confidence: 64%

Section: External Interference Resolution Across the Lifespansupporting

confidence: 57%

A Cognitive Framework for Understanding and Improving Interference Resolution in the Brain

Mishra

Anguera

Ziegler

et al. 2013

Progress in Brain Research

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“…In a paradigm previously described (Berry et al, 2009, Mishra et al, 2013a), participants were presented with three different tasks randomized across six blocks, with two blocks per task. There were two delayed recognition WM tasks, one with no interference (NI) during the WM delay and one with an interrupting stimulus (IS) during the WM delay that required attention.…”

Section: Methodsmentioning

confidence: 99%

Neural plasticity underlying visual perceptual learning in aging

2015

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Healthy aging is associated with a decline in basic perceptual abilities, as well as higher-level cognitive functions such as working memory. In a recent perceptual training study using moving sweeps of Gabor stimuli, Berry et al. (2010) observed that older adults significantly improved discrimination abilities on the most challenging perceptual tasks that presented paired sweeps at rapid rates of 5 & 10 Hz. Berry et al. further showed that this perceptual training engendered transfer-of-benefit to an untrained working memory task. Here, we investigated the neural underpinnings of the improvements in these perceptual tasks, as assessed by event-related potential (ERP) recordings. Early visual ERP components time-locked to stimulus onset were compared pre- and post- training, as well as relative to a no-contact control group. The visual N1 and N2 components were significantly enhanced after training, and the N1 change correlated with improvements in perceptual discrimination on the task. Further, the change observed for the N1 and N2 was associated with the rapidity of the perceptual challenge; the visual N1 (120–150 ms) was enhanced post-training for 10 Hz sweep pairs, while the N2 (240–280 ms) was enhanced for the 5 Hz sweep pairs. We speculate that these observed post-training neural enhancements reflect improvements by older adults in the allocation of attention that is required to accurately dissociate perceptually overlapping stimuli when presented in rapid sequence.

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“…Working memory involves the temporary storage and manipulation of information, necessary for a wide range of cognitive activities, whereas inhibitory control is the ability to suppress cognitive interference from irrelevant information that interferes with the task in hand . Cognitive interference occurs when new learned materials cause disturbance in memory retrieval . Proactive interference is when old memories inhibit retrieval of new memories, whereas retroactive interference is when new memories prevent recovery of old memories.…”

Section: Introductionmentioning

confidence: 99%

“…11 Cognitive interference occurs when new learned materials cause disturbance in memory retrieval. 12 Proactive interference is when old memories inhibit retrieval of new memories, whereas retroactive interference is when new memories prevent recovery of old memories.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a newly developed auditory–cognitive training system on speech recognition, central auditory processing and cognitive ability among older adults with normal cognition and with neurocognitive impairment

Yusof

Mukari

Dzulkifli

et al. 2019

Geriatrics Gerontology Int

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Aim To evaluate the efficacy of a newly developed auditory–cognitive training system on speech recognition, central auditory processing and cognition among older adults with normal cognition (NC) and with neurocognitive impairment (NCI). Methods A double‐blind quasi‐experiment was carried out on NC (n = 43) and NCI (n = 33) groups. Participants in each group were randomly assigned into treatment and control programs groups. The treatment group underwent auditory–cognitive training, whereas the control group was assigned to watch documentary videos, three times per week, for 8 consecutive weeks. Study outcomes that included Montreal Cognitive Assessment, Malay Hearing in Noise Test, Dichotic Digit Test, Gaps in Noise Test and Pitch Pattern Sequence Test were measured at 4‐week intervals at baseline, and weeks 4, 8 and 12. Results Mixed design anova showed significant training effects in total Montreal Cognitive Assessment and Dichotic Digit Test in both groups, NC (P < 0.001) and NCI (P < 0.01). The NC group also showed significant training effects in the Malay Hearing in Noise Test (quiet) (P < 0.01), Gaps in Noise Test (P < 0.001) and Pitch Pattern Sequence Test (humming) (P < 0.05). All training effects were sustained up to 4 weeks after the training ended. Conclusions The present study suggests that the newly developed auditory–cognitive training system has the potential to improve general cognition and some of the auditory processing abilities in both the NC and NCI groups. Because of the short test–retest intervals used in the present study, it is possible that the training effects were influenced by learning effect and, therefore, should be considered cautiously. Geriatr Gerontol Int 2019; 19: 768–773.

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Comparable mechanisms of working memory interference by auditory and visual motion in youth and aging

Cited by 22 publications

References 67 publications

A Cognitive Framework for Understanding and Improving Interference Resolution in the Brain

A Cognitive Framework for Understanding and Improving Interference Resolution in the Brain

Neural plasticity underlying visual perceptual learning in aging

Efficacy of a newly developed auditory–cognitive training system on speech recognition, central auditory processing and cognitive ability among older adults with normal cognition and with neurocognitive impairment

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