Comparable Effects of Angiotensin II and Converting Enzyme Blockade on Hemodynamics and Cardiac Hypertrophy in Spontaneously Hypertensive Rats.

Diverse effects of Ace inhibitors and angiotensin II receptor antagonists on prevention of cardiac hypertrophy and collagen distribution in spontaneously hypertensive rats

“…Other studies have clearly shown in SHRs that myocardial fibrosis is decreased by ACE inhibitors, such as lisinopril [32], enalapril [25] and trandolapril [37] and by angiotensin II AT 1 receptor antagonists such as losartan and candesartan [16,38]. Our data showed that the TVCC was similarly reduced by ACE inhibition and angiotensin II AT 1 receptor antagonism and this decrease was independent from the resulting decreased MAPs (R = 0.190; P = 0.115, N.S.).…”

“…Linz et al [31] have reported that ramipril, at a dose that did not decrease blood pressure, reversed LVH in aortic-banded rats. Moreover, Mori et al [32] have observed that short-term treatment with lisinopril 3 mg/kg/day for 2 weeks inhibited the progression of hypertension and suppressed the development of LVH in SHRs, whereas treatment with lisinopril 0.5 mg/kg/day for 2 weeks suppressed the development of LVH without reducing blood pressure. Nevertheless, it certainly remains that the prevention of myocardial cell hypertrophy and therefore the regression of LVH depend, at least in part, on afterload reduction.…”

Cardiovascular changes in spontaneously hypertensive rats are improved by chronic treatment with zofenopril

“…Our results are in agreement with those of Linz et al (1995) who have reported that ramipril, at a dose that did not decrease blood pressure, reversed LVH in aortic-banded rats. Moreover, Mori et al (1995) have observed that short-term treatment with lisinopril, 3 mg·kg -1 per day for 2 weeks, inhibited the progression of hypertension and suppressed the development of LVH in SHR, whereas 0.5 mg·kg -1 ·day -1 of lisinopril suppressed the development of LVH without reducing blood pressure. In order to clarify this point, the correlations between tissue ACE activities, blood pressure and cardiac hypertrophy were analysed by Takai et al (2004), using several ACE inhibitors.…”

“…(1995) who have reported that ramipril, at a dose that did not decrease blood pressure, reversed LVH in aortic‐banded rats. Moreover, Mori et al. (1995) have observed that short‐term treatment with lisinopril, 3 mg·kg −1 per day for 2 weeks, inhibited the progression of hypertension and suppressed the development of LVH in SHR, whereas 0.5 mg·kg −1 ·day −1 of lisinopril suppressed the development of LVH without reducing blood pressure.…”

Impaired Erythrocyte Filterability of Spontaneously Hypertensive Rats: Investigation by Nickel Mesh Filtration Technique

“…However, the present findings can not be extrapolated directly to clinical hypertension, despite SHR being an excellent model of human hypertension. 9,10 …”