Compaction characteristics of ethylcellulose in the presence of some channeling agents: Technical note

Oral Sustained Release Tablets of Zidovudine Using Binary Blends of Natural and Synthetic Polymers

“…Force was applied by turning the moving spindle until the tablet cracked diametrically. Tablet tensile strength was calculated according to the method reported by Emeje et al 14) The friability of the compacts was evaluated from the mass loss of 10 tablets tumbled for 100 revolutions (25 rpm for 4 min) using a friabilator (Erweka, Germany).…”

“…[13][14][15][16] These systems are attractive approaches from economic as well as process development view point. [16][17][18][19] A sustained release matrix tablet consists of a compressed compact containing a mixture of one or more bioactive agent(s) with one or more matrix former(s), which retards drug release.…”

“…[16][17][18][19] A sustained release matrix tablet consists of a compressed compact containing a mixture of one or more bioactive agent(s) with one or more matrix former(s), which retards drug release. 19) Hydrophilic swellable polymers have widely been used to control the release of drugs from matrix tablet formulations in the last three decades 13,14,20) and the increasing need for suitable polymers to achieve the desired drug release profile makes pharmaceutical research to widely screen a large variety of both synthetic and natural polymers which show drug release retarding ability. However, because of the cost of both synthesis of new polymeric materials and their safety, a new focus has been directed towards investigation of the use of polymer blends of pharmaceutically approved polymeric materials as matrix functional excipients to enhance single polymer performance.…”

Powder Compaction: Compression Properties of Cellulose Ethers

“…It was concluded that the utilisation of HPMC in the slugging/roller compaction, combined with dry granulation, was an efficient process which has potential for industrial scale up. Emeje et al, (2006) concluded that EC exhibited good compaction properties when it was employed alongside with some channelling agents (sorbitol, mannitol and PEG). MC also demonstrated good compression properties when employed in metronidazole tablets (Itiola & Pilpel, 1991).…”

Síntese e caracterização de beads acrílicos preparados por polimerização em suspensão visando aplicação como excipiente farmacêutico para compressão direta

“…Em decorrência, exercerá influência no peso médio dos comprimidos, na uniformidade de conteúdo, na dureza e nos resultados dos ensaios de dissolução. 9,63,64,72,76,77 A 64,78 Vale lembrar que, para materiais cujos resultados de IC% e FH sejam intermediários, a adição de agentes lubrificantes e antiaderentes nas formulações pode melhorar a capacidade de escoamento e a coesividade. 63,64,74 Os índices de Carr e de Hausner constituem-se como medidas indiretas do fluxo e não à facilidade ou velocidade com que as partículas escoam.…”