Compactibility improvement of metformin hydrochloride by crystallization technique

Barot, Bhavesh S.; Parejiya, Punit B.; Patel, Tushar M.; Parikh, Rajesh K.; Gohel, Mukesh C.

doi:10.1016/j.apt.2011.11.002

Cited by 29 publications

(22 citation statements)

References 24 publications

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“…It was illustrated that decreased value of 'a' and increased value of '1/b' compared with pure ABZ was a sign of improvement in packability of treated crystals [52]. Increased values of 'K' (Kuno's constant) compared with pure ABZ also indicated marked improvement in compressibility and packability of treated crystals [13,52].…”

Section: Packability Studymentioning

confidence: 99%

“…Weighed samples were compressed using 8 mm flat-faced punch at various forces (1, 3, 5, 7 and 9 tons) using KBr press (Techno-search Instruments, Mumbai, India) [15]. True density was considered as mass to volume of the pellet at a maximum applied force in tons (Here, 9 tons) [13].…”

Section: Heckel Plot Analysismentioning

confidence: 99%

“…They may also interact with the faces having more number of hydrogen bond forming groups to inhibit the growth of that particular faces [12]. Barot et al and Raval et al improved properties of poorly compressible Metformin HCl by its recrystallization in presence of PVP K-30 and lactose anhydrous, respectively [13,14]. Maghsoodi et al improved mechanical properties of naproxen as agglomerated forms [15].…”

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

Role of excipients in the crystallization of Albendazole

Raval¹,

Vaghela²,

Vachhani³

et al. 2015

Advanced Powder Technology

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Section: Packability Studymentioning

confidence: 99%

Section: Heckel Plot Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Role of excipients in the crystallization of Albendazole

Raval¹,

Vaghela²,

Vachhani³

et al. 2015

Advanced Powder Technology

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“…Smaller values of "A" for agglomerates compared to pure drug suggested that closest packing of the agglomerates can be obtained by applying low compression pressure. [36] Lower values of yield strength in case of agglomerates were sign of a little resistance to pressure, good densification, and easy compaction. Moreover, the lower Py and A values of agglomerates containing polymers compared to drug crystals may be attributed to plastic deformation.…”

Section: Resultsmentioning

confidence: 99%

Untitled

Sorathia¹

2016

AJP

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Purpose: The purpose of this study was to prepare sustained release (SR) spherical agglomerates with improved flow and compression properties using spherical crystallization technique. Methods: The spherical agglomerates of tiaprofenic acid were prepared by using quasi-emulsion solvent diffusion technique. Acetone and 0.1 N HCl were used as good solvent and poor solvent, respectively, while Eudragit RS100 and RL100 were used as release retardant polymers. The prepared agglomerates were evaluated for micromeritic, mechanical, and compression properties. Morphology and release characteristic of agglomerates was evaluated by scanning electron microscopy (SEM) analysis and in-vitro dissolution study, respectively. Differential scanning calorimetry (DSC) and Fourier transform-infrared (FT-IR) were performed to determine the presence of any drug-polymer interaction. Results: Spherical agglomerates were generated with uniform dispersion of drug within the matrix of polymer having size in the range of 100-500 µm. Due to spherical shape, agglomerates showed excellent flow, packability, compatibility, and mechanical properties. Good mechanical strength was indicated through higher crushing strength of agglomerates. Improved compressibility of agglomerates was indicated by lower σ 0 value in Heckel plot analysis, higher tensile strength, and lower elastic recovery compared to pure drug crystals. Sphericity and surface smoothness of agglomerates were revealed in SEM photos. In-vitro dissolution study indicated SR of drug for prolonged period. DSC and FT-IR indicated the absence of drug-polymer interaction and no change in molecular structure of drug due to agglomeration in the presence of polymers. Conclusion: Quasiemulsion solvent diffusion technique has been successfully utilized for the development of directly compressible SR spherical agglomerates of poorly soluble drugs like tiaprofenic acid.

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“…According to the probability function, insignificant terms (significance level = 5%, P ≥ 0.05) were excluded to derive reduced models. [24,25] Reduced equations derived for each independent variable are shown below in Equations 3-7: Figure 3]. Prepared experimental batches films thickness ranged within 300-750 µm.…”

Section: Preparation and Optimization Of Mouth Dissolving Filmmentioning

confidence: 99%

Application of Box-Behnken design to formulate and optimize multipolymeric fast dissolving film of rizatriptan benzoate

Mehta¹,

Dave²,

Dadhaniya³

et al. 2014

Asian J Pharm

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T he present investigation aims at formulation and optimization of multipolymeric fast dissolving film of rizatriptan benzoate.Three film forming polymers namely hydroxypropyl methylcellulose (HPMC), maltodextrin and polyvinylalcohol were explored using Box-Behnken experimental design to derive optimized fast dissolving film formulation using desirability function. Analysis of variance (ANOVA) was performed for five dependent variables tensile strength, folding endurance, load at yield, percentage elongation and percentage drug release in 30 s (Q 30 ). Mathematical regression equations were derived by applying ANOVA and validated using checkpoint batches. Results of the experimental design exposed that the effect of independent factors HPMC and maltodextrin significantly influenced the mechanical properties and percentage drug release from the film. Optimized batch was derived based on set criteria using desirability function. Reponses of the optimized formulation were tensile strength (500 N/m 2 ), folding endurance (203), load at yield (15.06 N/m 2 ), percentage elongation (4.56%) and Q 30 (60.03%) falling under acceptable limits. High percentage drug release from the film in simulated saliva and simulated gastric fluid reveal fast dissolving characteristics. Fast dissolving dosage form can help patients with diseases like migraine.

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Compactibility improvement of metformin hydrochloride by crystallization technique

Cited by 29 publications

References 24 publications

Role of excipients in the crystallization of Albendazole

Role of excipients in the crystallization of Albendazole

Untitled

Application of Box-Behnken design to formulate and optimize multipolymeric fast dissolving film of rizatriptan benzoate

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