Compact X-Band electron linac for radiotherapy and security applications

Kutsaev, Sergey; Agustsson, R.; Arodzero, A.; Berry, Robert W.; Bezhanov, A.; Boucher, S.; Chimalpopoca, O.; Diego, A.; Faillace, L.; Gavryushkin, D.; Harrison, Mike; Hartzell, Josiah; McNevin, Jacob; Ruelas, M.; Smirnov, Alexander Yu.; Verma, Avinash; Woods, Kaley

doi:10.1016/j.radphyschem.2021.109494

Cited by 13 publications

(1 citation statement)

References 18 publications

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“…Conventional 6 MV medical linacs produce a flattening filter-free dose rate of around 0.2 Gy/s at one meter from the X-ray target—three orders of magnitude too low. However, they are on the low end of the spectrum of linac powers [ 133 ]. A typical medical linac has a beam power on the order of 1 kW.…”

Section: High-current Electron Linear Accelerator For X-ray Flash-rt ...mentioning

confidence: 99%

Transformative Technology for FLASH Radiation Therapy

et al. 2023

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The general concept of radiation therapy used in conventional cancer treatment is to increase the therapeutic index by creating a physical dose differential between tumors and normal tissues through precision dose targeting, image guidance, and radiation beams that deliver a radiation dose with high conformality, e.g., protons and ions. However, the treatment and cure are still limited by normal tissue radiation toxicity, with the corresponding side effects. A fundamentally different paradigm for increasing the therapeutic index of radiation therapy has emerged recently, supported by preclinical research, and based on the FLASH radiation effect. FLASH radiation therapy (FLASH-RT) is an ultra-high-dose-rate delivery of a therapeutic radiation dose within a fraction of a second. Experimental studies have shown that normal tissues seem to be universally spared at these high dose rates, whereas tumors are not. While dose delivery conditions to achieve a FLASH effect are not yet fully characterized, it is currently estimated that doses delivered in less than 200 ms produce normal-tissue-sparing effects, yet effectively kill tumor cells. Despite a great opportunity, there are many technical challenges for the accelerator community to create the required dose rates with novel compact accelerators to ensure the safe delivery of FLASH radiation beams.

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Section: High-current Electron Linear Accelerator For X-ray Flash-rt ...mentioning

confidence: 99%