Compact wearable dual-mode imaging system for real-time fluorescence image-guided surgery

Zhu, Nan; Huang, Chih Yu; Mondal, Suman B.; Gao, Shengkui; Huang, Chongyuan; Gruev, Viktor; Achilefu, Samuel; Liang, Rongguang

doi:10.1117/1.jbo.20.9.096010

Cited by 12 publications

(10 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our opinion, the most promising application of the proposed multispectral AF imaging technique is associated with accomplishing the complete removal of the tumor and maximal preservation of the normal skin [112] by complementing such well-known techniques as Mohs micrographic surgery [113] and micrographic Doppler velocimetry [114], which are widely applied nowadays for removing BCC and SCC of the skin. In Mohs micrographic surgery, microscopic examination of all excised tissues occurs during the surgery, thereby providing tremendous accuracy and eliminating the need to estimate how far laterally or deep the cancer spreads [115].…”

Section: Discussionmentioning

confidence: 99%

Differentiation of basal cell carcinoma and healthy skin using multispectral modulation autofluorescence imaging: A pilot study

Chernomyrdin

Lesnichaya

Yakovlev

et al. 2019

J-BPE

View full text Add to dashboard Cite

An approach for differentiating basal cell carcinoma (BCC) and healthy skin by combining a multispectral modulation autofluorescence imaging with the linear discriminant analysis has been proposed. The experimental setup, which employs a 365-nm narrowband excitation, 4 replaceable bandpass filters and a digital camera, has been assembled and applied to study freshly excised samples of BCC. In the experimental setup, modulation of the UV-excitation and demodulation of the visible light images allow for both increasing a signal-to-noise ratio and suppressing a nonfluorescence background in the autofluorescence images of tissues. The observed results demonstrate an ability for distinguishing both ordinary and keratinized BCC from healthy skin justifying the perspectives of the multispectral modulation autofluorescence imaging use for non-invasive and intraoperative diagnosis of BCC and other low-pigmented malignancies of the skin.

show abstract

Section: Discussionmentioning

confidence: 99%

Differentiation of basal cell carcinoma and healthy skin using multispectral modulation autofluorescence imaging: A pilot study

Chernomyrdin

Lesnichaya

Yakovlev

et al. 2019

J-BPE

View full text Add to dashboard Cite

show abstract

“…1) which was described in detail earlier 30 . Briefly, the GAINS uses a focus-adjustable camera to capture color reflectance and NIR fluorescence and generates accurately aligned color-NIR superimposed images.…”

Section: Methodsmentioning

confidence: 99%

“…Reliance on a video feed for open surgery minimizes natural visual and tactile skills that surgeons utilize routinely during surgery. Based on the feedback from surgeons, we have developed an optical see-through (OST) HMD system that allows direct visualization of the surgical bed with provision to project fluorescence information directly to the user’s eyes 30 . In this study, we performed in vivo evaluation of the OST GAINS prototype in a subcutaneous mouse model of cancer for guiding tumor resection, lymphatic tracking and LN resection in a porcine model.…”

mentioning

confidence: 99%

Optical See-Through Cancer Vision Goggles Enable Direct Patient Visualization and Real-Time Fluorescence-Guided Oncologic Surgery

et al. 2017

Self Cite

View full text Add to dashboard Cite

Background The inability to directly visualize the patient and surgical site limits the use of current near infrared fluorescence-guided surgery systems for real-time sentinel lymph node biopsy and tumor margin assessment. Methods We evaluated an optical see-through goggle augmented imaging and navigation system (GAINS) for near-infrared fluorescence-guided surgery. Tumor-bearing mice injected with a near infrared cancer-targeting agent underwent fluorescence-guided tumor resection. Female Yorkshire pigs received hind leg intradermal indocyanine green injection and underwent fluorescence-guided popliteal lymph node resection. Four breast cancer patients received 99mTc-sulfur colloid and indocyanine green retroareolarly, before undergoing sentinel lymph node biopsy using radioactive tracking and fluorescence imaging. Three other breast cancer patients received indocyanine green retroareolarly before undergoing standard-of-care partial mastectomy, followed by fluorescence imaging of resected tumor and tumor cavity for margin assessment. Results Using near-infrared fluorescence from the dyes, the optical see-through GAINS accurately identified all mouse tumors, pig lymphatics, and 4 pig popliteal lymph nodes with high signal-to-background ratio. In 4 human breast cancer patients, 11 sentinel lymph nodes were identified with a detection sensitivity of 86.67± 0.27% for radioactive tracking and 100% for GAINS. Tumor margin status was accurately predicted by GAINS in all three patients, including clear margins in patients 1 and 2 and positive margins in patient 3 as confirmed by paraffin embedded section histopathology. Conclusions The optical see-through GAINS prototype enhances near infrared fluorescence-guided surgery for sentinel lymph node biopsy and tumor margin assessment in breast cancer patients without disrupting the surgical workflow in the operating room.

show abstract

“…Optical see-through GAINS prototype showing color-NIR camera (1 and 6), liquid crystal glass eyepiece (2 and 3), distance sensor (4), and light sensor (5).Reproduced with permission. [50] Copyright 2015, Society of Photo-Optical Instrumentation Engineers (SPIE). intraoperative visualization of HCC in 9 patients using ICG as the contrast agent.…”

Section: Cancer Visualizationmentioning

confidence: 99%

Head‐Mounted Devices for Noninvasive Cancer Imaging and Intraoperative Image‐Guided Surgery

Mondal

Tsen

Achilefu

2020

Adv Funct Materials

Self Cite

View full text Add to dashboard Cite

Medical imaging methods have improved the detection of human diseases with increasing accuracy. The ability to probe molecular processes noninvasively or using tissue‐selective imaging agents and nanoparticles has made it possible to localize, identify the stage, and determine the functional status of pathological lesions. The challenges in detecting cancer particularly have driven the development of diverse imaging technologies. While earlier cancer imaging methods enabled preoperative evaluation, the need to track and visualize cancer location in the operating room itself has ushered in new systems capable of providing concurrent images of cancer during surgery. Intraoperative use of conventional clinical imaging modalities is often limited by bulky hardware design, prohibitive cost, lack of real‐time image display, and compatibility with conventional hardware interfaces. For these reasons, focus on fluorescence‐guided surgery (FGS) devices has increased to take advantage of real‐time, high‐resolution, functional imaging with hardware that has become increasingly amenable to miniaturization. In particular, the adaptation of wearable devices for FGS presents hands‐free capability for optimal navigation during cancer surgery. The evolution of head‐mounted devices in the operating room and adaptation for FGS is highlighted. Key challenges to wide clinical adoption of this imaging platform are identified and potential future directions are suggested.

show abstract

Compact wearable dual-mode imaging system for real-time fluorescence image-guided surgery

Cited by 12 publications

References 14 publications

Differentiation of basal cell carcinoma and healthy skin using multispectral modulation autofluorescence imaging: A pilot study

Differentiation of basal cell carcinoma and healthy skin using multispectral modulation autofluorescence imaging: A pilot study

Optical See-Through Cancer Vision Goggles Enable Direct Patient Visualization and Real-Time Fluorescence-Guided Oncologic Surgery

Head‐Mounted Devices for Noninvasive Cancer Imaging and Intraoperative Image‐Guided Surgery

Contact Info

Product

Resources

About