Compact Vesicles Self-Assembled from Binary Graft Copolymers with High Hydrophilic Fraction for Potential Drug/Protein Delivery

Wang, Yupeng; Wang, Lina; Li, Bin; Cheng, Yanxiang; Zhou, Dongfang; Chen, Xuesi; Jing, Xiabin; Huang, Yubin

doi:10.1021/acsmacrolett.7b00549

Cited by 25 publications

(21 citation statements)

References 38 publications

(56 reference statements)

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“…Added the prepared RES‐zein dropwise to the SHA solution in a ratio of 1:4, kept stirring at 700 rpm, and then removed the ethanol through dialysis (MWCO, 3,500 Da) (Wang et al., 2017).…”

Section: Methodsmentioning

confidence: 99%

In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol

Shi

Wang

Tang

et al. 2021

Food Science & Nutrition

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Resveratrol (RES) loaded Zein‐SHA (low‐molecular‐weight sodium hyaluronate) nanoparticles with average diameter of about 152.13 nm and polydispersity index (PDI) of 0.122, which can be used to encapsulate, protect and deliver resveratrol. By measuring ABTS free radical scavenging ability and iron (III) reducing power, it was determined that encapsulated resveratrol has higher in vitro antioxidant activity than free resveratrol. When tested with murine breast cancer cells 4T1, the encapsulated resveratrol also showed higher antiproliferative activity than free resveratrol, with IC50 values of 14.73 and 17.84 μg/ml, respectively. The colloidal form of resveratrol developed in this research may be particularly suitable for functional foods and beverages, as well as dietary supplements and pharmaceutical products.

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“…Added the prepared RES‐zein dropwise to the SHA solution in a ratio of 1:4, kept stirring at 700 rpm, and then removed the ethanol through dialysis (MWCO, 3,500 Da) (Wang et al., 2017).…”

Section: Methodsmentioning

confidence: 99%

In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol

Shi

Wang

Tang

et al. 2021

Food Science & Nutrition

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“…There are more examples of polymersomes assembled from graft co-polymers, but they are discussed elsewhere. [32] Formation of micelles from the amphiphilic triblock-copolymer PEG-b-P3HB-b-PEG via nanoprecipitation was observed. [29] There was no follow up for possibilities of polymersome formation from similar building blocks, this can be interesting to further investigate.…”

Section: Polyhydroxyalkanoatesmentioning

confidence: 98%

Designing Molecular Building Blocks for Functional Polymersomes

Rijpkema

Toebes

Maas

et al. 2019

Israel Journal of Chemistry

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In recent years various polymeric vesicles have been reported that show promising results for drug delivery applications, nanomotors and/or nanoreactors. These polymeric vesicles can be assembled from many different materials and various coupling reactions have been applied for functionalization of the vesicles. However, the designs reported are still rather simple, as it is challenging to mimic biological complex systems. In this review we focus on the properties of widely used hydrophobic polymers to better understand polymersome properties for various applications. Examples are shown of how researchers have used and modulated block‐copolymers and their properties to their advantage. Furthermore, an overview of possible end group functionalizations of nanoparticles is reported, giving insight in recent developments of smart nanoparticles for biomedical applications.

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“…Nevertheless, much less attention has been paid to the confinement of SRPs inside the spherical container, especially considering SRP mixtures with polydispersity. The physical effects from the topological constraints and confinements play significant roles in the structure and function of individual genetic materials [34][35][36][37][38], such as chromosome shape in elongated bacterial cells [39], DNA (or DNA-actin filament mixtures) self-organization in a cell-size confinement [40], and drug delivery from spherical vesicles [41,42], etc.…”

Section: Introductionmentioning

confidence: 99%

Entropy-Induced Separation of Binary Semiflexible Ring Polymer Mixtures in Spherical Confinement

Zhou¹,

Guo²,

Li³

et al. 2019

Polymers

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Coarse-grained molecular dynamics simulations are used to investigate the conformations of binary semiflexible ring polymers (SRPs) of two different lengths confined in a hard sphere. Segregated structures of SRPs in binary mixtures are strongly dependent upon the number density of system (ρ), the bending energy of long SRPs (Kb, long), and the chain length ratio of long to short SRPs (α). With a low ρ or a weak Kb, long at a small ratio α, long SRPs are immersed randomly in the matrix of short SRPs. As ρ and bending energy of long SRPs (Kb, long) are increased up to a certain value for a large ratio α, a nearly complete segregation between long and short SRPs is observed, which can be further characterized by the ratio of tangential and radial components of long SRPs velocity. These explicit segregated structures of the two components in spherical confinement are induced by a delicate competition between the entropic excluded volume (depletion) effects and bending contributions.

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Compact Vesicles Self-Assembled from Binary Graft Copolymers with High Hydrophilic Fraction for Potential Drug/Protein Delivery

Cited by 25 publications

References 38 publications

In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol

In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol

Designing Molecular Building Blocks for Functional Polymersomes

Entropy-Induced Separation of Binary Semiflexible Ring Polymer Mixtures in Spherical Confinement

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