Compact Quadruple Therapy with the Lamivudine/Zidovudine Combination Tablet Plus Abacavir and Efavirenz, Followed by the Lamivudine/Zidovudine/Abacavir Triple Nucleoside Tablet Plus Efavirenz in Treatment-Naïve HIV-Infected Adults

J, Ruane Peter; David, Matthew; David, Henry; Timothy, J Babinchak; Amy, S van Kempen; Teresa, L Kauf; Susan, Ann; Yau, Linda; Siegrid, M Hessenthaler; Goodwin, Diane; Jaime, E Hernandez

doi:10.1310/mm9w-bau0-bt6q-401b

Cited by 7 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Innovations in containers, labeling, and packaging include blister packs, PillPack, and a variety of adherence devices ranging from digital pill containers to dispensing devices. [13][14][15][16] Studies have shown limitations to many of these innovations, and, overall, no significant impact on adherence has resulted from the use of simple adherence devices. 17,18 Over 700 digital apps exist as reminders to improve medication adherence, but users often report technical difficulties like schedule inflexibility, since many do not take, or need to take, their medication at an exact time, as well as notification fatigue from daily timed reminders to take their medication.…”

Section: Original Manuscriptmentioning

confidence: 99%

Medication Management Strategies to Support Medication Adherence: Interview Study With Older Adults (Preprint)

Gualtieri,

Rigby,

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

BACKGROUND Medication adherence is a pervasive problem in medicine; approximately half of U.S. adults do not take their prescriptions as directed. Older adults are a particularly vulnerable population due to the greater likelihood of taking medication and the desire to “age in place.” Home medication management is understudied in older adults, including factors that impact the development and effectiveness of strategies under both routine and anomalous circumstances. This interview study is an exploration into how older adults manage their medication in their homes and what contributes to or detracts from adherence. OBJECTIVE The purpose of this study was to (1) understand how older adults develop medication management strategies; (2) identify strategies that lead to adherence; (3) learn more about how older adults think about their medication; and (4) explore interventions that increase medication adherence. METHODS This study utilized a qualitative, semi-structured interview design to elicit information about daily routines and perceived barriers to and facilitators of adherence. Participants were recruited through the Osher Lifelong Learning Institute at Tufts University, and interviews were conducted over video conference. Thematic, qualitative analysis was performed by reviewing and coding recordings and transcripts. RESULTS Twenty-two participants aged 50 and older were interviewed. Participants reported not receiving guidance about medication adherence from healthcare providers, and instead developing strategies on their own, with more than half (59%) using trial and error. The medication management strategies developed by study participants were all unique. These strategies, for most participants, encompassed their prescription medication as well as any vitamins or supplements they took with no demarcation between what was prescribed or recommended by a doctor or what they discovered independently. Pill cases (77%) were more popular than pill bottles (23%) for storage of daily medication. Most participants (86%) stored their pill cases or bottles in visible locations in the home, and those using pill cases developed unique routines for refilling them. Participants overwhelmingly relied on at least two routines or objects as reminders to take their medication. When nonadherence occurred, it was generally associated with a change in routine, such as oversleeping, receiving a phone call, missing a mealtime, or traveling. Finally, participants varied in how they identified their prescription medications, based on name, appearance, or purpose. CONCLUSIONS Participants in our study varied considerably in their home medication management strategies and developed unique routines to remember to take their medication as well as to refill their pill cases. While this study was small, the analysis suggests that there are opportunities for providers to provide adherence guidance to older adults, especially when receiving their first long-term prescription or when their regimen changes, and to design better aids to adherence that leverage established daily routines.

show abstract

Section: Original Manuscriptmentioning

confidence: 99%

Medication Management Strategies to Support Medication Adherence: Interview Study With Older Adults (Preprint)

Gualtieri,

Rigby,

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

A systematic review of treatment fatigue among HIV-infected patients prescribed antiretroviral therapy

Claborn

Meier

Miller

et al. 2014

Psychology, Health & Medicine

120

View full text Add to dashboard Cite

HIV treatment requires lifelong adherence to medication regimens that comprise inconvenient scheduling, adverse side effects, and lifestyle changes. Antiretroviral adherence and treatment fatigue have been inextricably linked. Adherence in HIV-infected populations has been well investigated; however, little is known about treatment fatigue. This review examines the current state of the literature on treatment fatigue among HIV populations and provides an overview of its etiology and potential consequences. Standard systematic research methods were used to gather published papers on treatment fatigue and HIV. Five databases were searched using PRISMA criteria. Of 1,557 studies identified, 21 met the following inclusion criteria: (a) study participants were HIV-infected, (b) participants were prescribed antiretroviral medication, (c) the article referenced treatment fatigue, (d) the article was published in a peer-reviewed journal, and (e) text was available in English. Only seven articles operationally defined treatment fatigue, with three themes emerging throughout the definitions: (1) pill burden, (2) loss of desire to adhere to the regimen, and (3) nonadherence to regimens as a consequence of treatment fatigue. Based on these studies, treatment fatigue may be defined as “decreased desire and motivation to maintain vigilance in adhering to a treatment regimen among patients prescribed long-term protocols.” The cause and course of treatment fatigue appear to vary by developmental stage. To date, only structured treatment interruptions have been examined as an intervention to reduce treatment fatigue in children and adults. No behavioral interventions have been developed to reduce treatment fatigue. Further, only qualitative studies have examined treatment fatigue conceptually. Studies designed to systematically assess treatment fatigue are needed. Increased understanding of the course and duration of treatment fatigue is expected to improve adherence interventions, thereby improving clinical outcomes for individuals living with HIV.

show abstract

New Nucleoside/Nucleotide Backbone Options: A Review of Recent Studies

Ruane¹,

DeJesus²

2004

JAIDS Journal of Acquired Immune Deficiency Syndromes

View full text Add to dashboard Cite

The nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) class continues to serve as an important component of the standard of care for HIV infection. Combinations of dual NRTIs/NtRTIs with protease inhibitors (PIs) or nonnucleoside reverse transcriptase inhibitors (NNRTIs) remain the most commonly used regimens in clinical practice. In recent years, clinical outcomes data on previously novel NRTI/NtRTI backbone combinations have provided clinicians with new options to address potency, tolerability, and convenience of antiretroviral therapy. However, the tolerability, drug-drug interactions, and resistance profiles of specific regimens using new NRTI/NtRTI combinations must be weighed against the needs and preferences of individual patients. This review summarizes recent efficacy and safety data on emerging NRTI/NtRTI combination backbones, including tenofovir DF (TDF) with lamivudine (3TC), abacavir with 3TC, didanosine (ddI) with 3TC, ddI with emtricitabine (FTC), and TDF with FTC.

show abstract

Compact Quadruple Therapy with the Lamivudine/Zidovudine Combination Tablet Plus Abacavir and Efavirenz, Followed by the Lamivudine/Zidovudine/Abacavir Triple Nucleoside Tablet Plus Efavirenz in Treatment-Naïve HIV-Infected Adults

Abstract: COM/ABC/EFV or TZV/EFV produced potent, durable virologic suppression and immunologic benefits, was associated with high adherence rates, and was generally well tolerated.

Cited by 7 publications

References 14 publications

Medication Management Strategies to Support Medication Adherence: Interview Study With Older Adults (Preprint)

Medication Management Strategies to Support Medication Adherence: Interview Study With Older Adults (Preprint)

A systematic review of treatment fatigue among HIV-infected patients prescribed antiretroviral therapy

New Nucleoside/Nucleotide Backbone Options: A Review of Recent Studies

Contact Info

Product

Resources

About