Abstract:During thyroid surgery fast and reliable intra-operative pathological
feedback has the potential to avoid a two-stage procedure and
significantly reduce health care costs in patients undergoing a
diagnostic hemithyroidectomy (HT). We explored higher harmonic
generation (HHG) microscopy, which combines second harmonic generation
(SHG), third harmonic generation (THG), and multiphoton excited
autofluorescence (MPEF) for this purpose. With a compact, portable HHG
microscope, images of freshly excised healthy tiss… Show more
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