Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye

Salas, Matthias; Augustin, Marco; Felberer, Franz; Wartak, Andreas; Laslandes, Marie; Ginner, Laurin; Niederleithner, Michael; Ensher, Jason; Minneman, Michael; Leitgeb, Rainer A.; Drexler, Wolfgang; Lévecq, Xavier; Schmidt‐Erfurth, Ursula; Pircher, Michael

doi:10.1364/boe.9.001871

Cited by 22 publications

(21 citation statements)

References 58 publications

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“…The represented planes can be taken as reference for the direction nomenclature used in this review. In this unregistered OCT volume, acquired with a custom made device at Medical University of Vienna (SS-OCT at 1050 nm with 200 kHz A-scan rate, 200 Hz B-scan rate) [22], the distortions are visible in the slow and coronal (en face) planes. The fast plane is often considered artefact free, as the frame rate acquisition in modern devices is faster than the motion expected to be observed in the retina.…”

Section: Involuntary Eye Motionmentioning

confidence: 99%

Review on Retrospective Procedures to Correct Retinal Motion Artefacts in OCT Imaging

et al. 2019

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Motion artefacts from involuntary changes in eye fixation remain a major imaging issue in optical coherence tomography (OCT). This paper reviews the state-of-the-art of retrospective procedures to correct retinal motion and axial eye motion artefacts in OCT imaging. Following an overview of motion induced artefacts and correction strategies, a chronological survey of retrospective approaches since the introduction of OCT until the current days is presented. Pre-processing, registration, and validation techniques are described. The review finishes by discussing the limitations of the current techniques and the challenges to be tackled in future developments.

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Section: Involuntary Eye Motionmentioning

confidence: 99%

Review on Retrospective Procedures to Correct Retinal Motion Artefacts in OCT Imaging

et al. 2019

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“…Using a multimodal hybrid OCM-FL prototype [ 43 ], we evaluated FL intensities, OCM attenuation (ATT) coefficients and cell density maps across three different brain tumor entities, namely LGG (including WHO grade II and III gliomas), GB, and MET. For a deeper understanding of the intra-tumoral heterogeneity of our samples, we used a swept-source OCT setup at 1060 nm [ 44 ] for large field-of-view (FOV) scans. All findings were validated against the gold standard histology.…”

Section: Introductionmentioning

confidence: 99%

Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning

Gesperger

Lichtenegger

Roetzer

et al. 2020

Cancers

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Fluorescence-guided surgery is a state-of-the-art approach for intraoperative imaging during neurosurgical removal of tumor tissue. While the visualization of high-grade gliomas is reliable, lower grade glioma often lack visible fluorescence signals. Here, we present a hybrid prototype combining visible light optical coherence microscopy (OCM) and high-resolution fluorescence imaging for assessment of brain tumor samples acquired by 5-aminolevulinic acid (5-ALA) fluorescence-guided surgery. OCM provides high-resolution information of the inherent tissue scattering and absorption properties of tissue. We here explore quantitative attenuation coefficients derived from volumetric OCM intensity data and quantitative high-resolution 5-ALA fluorescence as potential biomarkers for tissue malignancy including otherwise difficult-to-assess low-grade glioma. We validate our findings against the gold standard histology and use attenuation and fluorescence intensity measures to differentiate between tumor core, infiltrative zone and adjacent brain tissue. Using large field-of-view scans acquired by a near-infrared swept-source optical coherence tomography setup, we provide initial assessments of tumor heterogeneity. Finally, we use cross-sectional OCM images to train a convolutional neural network that discriminates tumor from non-tumor tissue with an accuracy of 97%. Collectively, the present hybrid approach offers potential to translate into an in vivo imaging setup for substantially improved intraoperative guidance of brain tumor surgeries.

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“…Unstable or drifting mechanical movements can lead to overall degradation of source performance 11,14,15,22 .…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Insight Photonic Solutions, Inc. (Lafayette, CO, USA) reported an akinetic wavelength-swept laser with an integrated semiconductor opto-electronic design without the need for external cavity coupling at the center wavelength of 1060 nm, 1310 nm, and 1550 nm 14,15,22 . The company successfully showed an SS-OCT image of the human retina, skin, and tooth and an OCT angiogram of human skin owing to the phase-stable swept source.…”

Section: Introductionmentioning

confidence: 99%

Akinetic swept-source optical coherence tomography based on a pulse-modulated active mode locking fiber laser for human retinal imaging

Lee

Kim

Shin

et al. 2018

Sci Rep

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Optical coherence tomography (OCT) is a noninvasive imaging modality that can provide high-resolution, cross-sectional images of tissues. Especially in retinal imaging, OCT has become one of the most valuable imaging tools for diagnosing eye diseases. Considering the scattering and absorption properties of the eye, the 1000-nm OCT system is preferred for retinal imaging. In this study, we describe the use of an akinetic swept-source OCT system based on a pulse-modulated active mode locking (AML) fiber laser at a 1080-nm wavelength for in-vivo human retinal imaging. The akinetic AML wavelength-swept fiber laser was constructed with polarization-maintaining fiber that has an average linewidth of 0.625 nm, a spectral bandwidth of 81.15 nm, and duty ratio of 90% without the buffering method. We successfully obtained in-vivo human retinal images using the proposed OCT system without the additional k-clock and the frequency shifter that provides a wide field of view of 43.1°. The main retina layers, such as the retinal pigment epithelium, can be distinguished from the OCT image with an axial resolution of 6.3 μm with this OCT system.

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Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye

Cited by 22 publications

References 58 publications

Review on Retrospective Procedures to Correct Retinal Motion Artefacts in OCT Imaging

Review on Retrospective Procedures to Correct Retinal Motion Artefacts in OCT Imaging

Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning

Akinetic swept-source optical coherence tomography based on a pulse-modulated active mode locking fiber laser for human retinal imaging

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