Comorbidity: pulmonary tuberculosis and chronic obstructive pulmonary disease

Jakimova, Marina Artemovna; Karpina, Natalya; Gordeeva, Olga; Asanov, Rasul

doi:10.1183/13993003.congress-2019.pa2969

Cited by 2 publications

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“…Previous studies have also reported the negative influence of comorbidities on clinical outcomes in PTB ( 26 ). The CCI was developed as a comorbidity-based indicator for estimating the risk of death and classifying the severity of a patient's clinical condition ( 27 ).…”

Section: Discussionmentioning

confidence: 91%

Effects of smoking on the severity and transmission of pulmonary tuberculosis: A hospital-based case control study

Feng

Yang

et al. 2023

Front. Public Health

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IntroductionThere is a high incidence of both smoking and tuberculosis (TB) in China. This study examined the risk factors for severe pulmonary TB (PTB) and positive tubercle bacilli in sputum.MethodsWe conducted a retrospective case-control study in a tertiary hospital from January 2017 to December 2018 (n = 917). The clinical and biological characteristics of patients were collected, and univariable and multivariable logistic regression analyses were performed to assess the factors associated with smoking in terms of the severity and transmission of PTB.ResultsPositive tubercle bacilli in sputum and severe PTB were much higher in smoking patients. Together with nutrition status, heavy smoking exhibited a 284% greater risk in severe PTB. Positive tubercle bacilli in sputum was significantly associated with hypoproteinemia and smoking regardless of the status, duration, and degree.ConclusionBecause cigarette smoking was strongly and inversely associated with hypoproteinemia, we conclude that smoking plays a critical role in the severity and transmission of PTB. Smoking cessation interventions should be employed to prevent severe PTB and decrease the transmission of PTB.

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Section: Discussionmentioning

confidence: 91%

Effects of smoking on the severity and transmission of pulmonary tuberculosis: A hospital-based case control study

Feng

Yang

et al. 2023

Front. Public Health

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“…Some studies have attempted to identify an indicator of comorbidity severity and mortality risk [48,49]. The Charlson Comorbidity Index (CCI) was modified and improved based on pathology analysis [29,49].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Comorbidity in Patients with Drug-Resistant Tuberculosis

Starshinova,

Nazarenko,

Belyaeva

et al. 2023

Pathogens

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A wide range of comorbidities, especially in multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) patients, markedly complicates selecting effective treatment of tuberculosis (TB) and preventing the development of adverse events. At present, it is impossible to assess the severity of comorbid pathologies and develop indications for the administration of accompanying therapy in TB patients. The aim of this study was to identify the difference in the range of comorbidities between patients with MDR-TB and XDR-TB and assess the impact of comorbidities on TB treatment. Materials and Methods: A retrospective, prospective study was conducted where 307 patients with MDR-TB and XDR-TB pulmonary tuberculosis aged 18 to 75 years who received eTB treatment from 2016 to 2021 in St. Petersburg hospitals were analyzed. The analysis showed that the comorbidity level in MDR-TB and XDR-TB patients with TB treatment success and treatment failure was comparable with the use of the Charlson Comorbidity Index (CCI). The CCI demonstrated declining data in terms of TB treatment outcome period in both groups. A slight predominance of CCI score (3 to 4 points) in XDR-TB (22.7%) vs. MDR-TB (15.4%) patients was found. In the case of an TB treatment failure, the CCI level in MDR-TB vs. XDR-TB patients was characterized by a significantly higher rate of low magnitude (ranging from 1 to 2 points) in 21.1% vs. 4.5% (p < 0.05), which was higher in XDR-TB patients (ranging from 4 to 5 points, in 10.0% vs. 0, χ2 = 33.7 (p < 0.01)). Chronic viral hepatitis B and C infection, cardiovascular pathology, chronic obstructive pulmonary disease, and chronic alcoholism were found to be significant comorbidity factors that influenced the TB treatment success. Conclusions: It is evident that XDR-TB patients comprise a cohort with the most severe disease course due to comorbidities impacting TB treatment efficacy. The obtained data pointed to the need to determine comorbidity severity in patients with drug-resistant Mbt prior to administering TB treatment schemes.

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Comorbidity: pulmonary tuberculosis and chronic obstructive pulmonary disease

Cited by 2 publications

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Effects of smoking on the severity and transmission of pulmonary tuberculosis: A hospital-based case control study

Effects of smoking on the severity and transmission of pulmonary tuberculosis: A hospital-based case control study

Assessment of Comorbidity in Patients with Drug-Resistant Tuberculosis

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