Comorbidity profiles among patients with alopecia areata: The importance of onset age, a nationwide population-based study

Chu, Shih-Ming; Chen, Yi Ju; Tseng, Wei Cheng; Lin, Ming; Chen, Tzeng Ji; Hwang, Chian Yaw; Chen, Chih Chiang; Lee, Ding Dar; Wang, Wen Jen; Liu, Han Nan

doi:10.1016/j.jaad.2010.08.032

Cited by 221 publications

(224 citation statements)

References 44 publications

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“…Anti-TPO ak pozitifliği erişkinlerde AA'lı hastalarda yapılan çalışmalarda %25'lere varan düzeyde görülebilmektedir 20,22 . Dört bin üçyüz otuz dört AA'lı olgunun komorbidite açısından incelendiği son bir çalışma da ise çocukluk yaş grubu da dahil olmak üzere yaş aralığına göre AA varlığının tiroidit, sistemik lupus eritematozus, atopik dermatit, psoriazis, RA gibi hastalıklara eşlik etme olasılığının anlamlı olarak arttığı gösterilmiştir 23 24 . Türkiye'de çocukluk çağındaki popülasyona ait TFT anomalilerine dair net bir bilgi bulunamamasına karşın, iyot eksikliğinin endemik olarak saptandığı ülkemizde TFT anomalilerinin beklenenden yüksek olabileceği göz önüne alınmalıdır.…”

Section: Discussionunclassified

Childhood alopecia areata: A study of 89 patients

Doğan¹,

Ersoy‐Evans²,

Gönç³

et al. 2014

TURKDERM

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Background and Design: Alopecia areata (AA) is a frequent type of acquired hair loss with a sudden onset. The aim of this study was to investigate the epidemiological and clinical features of AA and diseases associated with AA in the Turkish pediatric population. Materials and Methods:We retrospectively evaluated the medical data of patients under 16 years of age who were admitted to the pediatric dermatology outpatient clinic at Hacettepe University Hospital between 2006 and 2011 with a diagnosis of AA, alopecia totalis (AT) and alopecia universalis (AU). Results: A total of 89 patients (34 females and 55 males), were included in this study. The mean age of the subjects was 9.8±3.4 years (range:18 months-16 years). 9% (n=8) patients had other autoimmune diseases: Hashimoto's thyroiditis in 5, vitiligo in 1, juvenile rheumatoid arthiritis (JRA) in 1 and morphea in 1 patient. AA was located on the scalp in 86.5% (n=77) of the patients, 7.9% (n=7) of the patients had AA on the scalp together with eyelashes, eyebrows and the body. AT was noted in 1, AU was noted in 4 patients. Severity of hair loss was <25% in 94.3% (n=84) of the patients according to the involved area. Hashimoto's thyroiditis was diagnosed in 5 patients; these patients had normal thyroid function tests (TFT). TFT abnormalities were detected in 27% (n=24) of the patients. 24.7% (n=22) of these patients were diagnosed

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Section: Discussionunclassified

Childhood alopecia areata: A study of 89 patients

Doğan¹,

Ersoy‐Evans²,

Gönç³

et al. 2014

TURKDERM

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“…Although the pathogenesis of AA is still unknown, strong evidence indicates a link between AA and innate and adaptive immune response [4]. The association with autoimmune diseases such as autoimmune thyroid diseases, vitiligo and atopy has been reported [5].…”

Section: Discussionmentioning

confidence: 99%

When is the Appropriate Time to do Hair Transplantation in Recalcitrant Alopecia Areata, or Never?

Pathomvanich¹,

Tangjaturonrusamee²,

Asawaworarit³

2014

Hair Therap Transplantat

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Alopecia areata (AA) is a common and distressing condition in populations worldwide. The course of this condition is unpredictable and remains elusive. Patients with AA have a negative appraisal of their self-image, resulting in a demand for any effective treatment options. Hair transplantation might be considered for those patients who have exhausted standard clinical therapies for a period of time. However, the appropriate time to do hair transplantation in recalcitrant alopecia areata is still in question, or may be never. Keywords: Alopecia areata; Hair transplantation Case ReportA 31-year old Asian male presented with a 6-year history of patchy hair loss on his scalp and right eyebrow. He was initially seen by dermatologists and had been treated with topical corticosteroids, intra lesional corticosteroid and 5% minoxidil lotion for the past 5-6 years without improvement. There was no history of autoimmune diseases, thyroid diseases or atopy as well as, no family history of alopecia areata. Examination of the scalp showed a non-scarring alopecic patch sized 3.5×6.5 cm on the right frontal area and another non-scarring alopecic patch sized 1×1 cm on the right eyebrow (Figures 1a and 2a). Pull test was negative on both sites. Pitting nails were not observed.Scalp and eyebrow were biopsied with standard 4 mm punches. The histopathology of the biopsy from the scalp showed decreased hair follicles in anagen phase and lymphocytic infiltration around the hair bulbs and fibrous tissue. The biopsy from the eyebrow revealed only decreased number of the hair follicles. The histopathology results were consistent with alopecia areata.

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“…Muayene eden doktorun değerlendirme notlarına bakıldığında da hastaların yakınmaları %60'ında kronik persistan ve %15,3'ünde kronik, ancak ataklar halinde seyir gösterdiği, sadece yine %15,3 hastada akut seyir olduğu saptandı. AA'nın tiroid hastalıklarıyla birlikteliği ile ilgili çok çalışma yapılmış ancak görülme sıklığı ile ilgili ortak bir veriye ulaşılamamıştır, AA ve tiroid hastalıkları birlikteliği %0-48 arasında değişen oranlarda bildirilmiştir (43)(44)(45)(46). Tiroid hastalıklarıyla AA şiddeti ilişkisi gösterilememiş ancak hastalık süresiyle ilişkili olabilir düşüncesinden yola çıkarak yeni AA tanısı alan hastalarda yapılan bir çalışmada anormal tiroid fonksiyonları, antitiroid otoantikorları %24 hastada tespit edilmiş ve bunların çoğunun subklinik hipotiroidizm ve ötiroid hashimato tiroiditi hastaları olduğu gösterilmiştir (47).…”

Section: Bulgularunclassified

Experience of a Hair Disease Unit: Analysis of 1.617 Cases

Temel¹,

Şenol²,

Nazlım³

et al. 2016

tdd

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Amaç: Ülkemizde saç hastalıkları başvurularına ait tanımlayıcı veriler oldukça azdır. Bu çalışmada, mezuniyet öncesi ve sonrası eğitim programlarının oluşturulmasına katkı sağlayacağı düşüncesiyle, bölgemizde gözlenen saç hastalıkları hakkında bilgi sahibi olmak, ünitemize başvuran hastaların özelliklerini tanımlamak ve saç hastalıklarında tanısal yaklaşıma katkı sağlayabilecek verileri belirlemek amaçlanmıştır. Yöntemler: Tanımlayıcı epidemiyolojik çalışmamızda, üniversitemiz Saç Hastalıkları Ünitesi'ne Mayıs 2011-Mayıs 2014 tarihleri arasında başvuran, ardışık 1,617 yeni hastanın verileri geriye dönük olarak değerlendirildi. Bulgular: Genel poliklinik başvuruları arasında saç hastalıkları %7 oranında saptandı. Hastaların yaş ortalaması 32,28±15,45 yaş (0-84 yaş) olup kadın/erkek oranı 2,26 olarak bulundu. Yakınmaların %60 hastada kronik persistan seyir gösterdiği ve hastaların %69,1'inin başvuru anında yakınma sürelerinin yıllarla ifade edildiği saptandı. En sık, androgenetik alopesi (AGA), telojen effluvium ve alopesi areata tanıları konmuştu (sırasıyla; %45,8, %39,4, %17,8). Tanı amacıyla 339 hastada (%20,9) trikoskopi yapılmış ve bunların %85'inde saptanan bulgular tanıya yardımcı olmuştu. Sonuç: Bölgemizde saç sorunları nedeniyle başvuru oranı genel poliklinik sayısı içinde önemli bir miktardadır. AGA, telojen effluvium ve alopesi areatanın iyi tanınması ve muayenede trikoskopi gibi yardımcı yöntemlerin kullanılabilmesi saç hastalıkları alanında başarıyı arttıracaktır. Objective: There are few epidemiological descriptive data on the prevalence of hair diseases in our country. In this study, we aimed to have information about the hair diseases observed in our region, to describe the characteristics of patients admitted to our unit and to supply data for the diagnostic approach which will contribute to developing undergraduate and postgraduate training programs. Methods: In this descriptive epidemiologic study, data of 1.617 consecutive new patients admitted to our University Hair Diseases Unit between May 2011 and May 2014 were analyzed retrospectively. Results: Hair diseases were observed in 7% of the patients who applied to the dermatology outpatient clinic. The mean age of patients was 32.28±15.45 years (0-84 years, range) and female/male ratio was 2.26. Complaints were as chronic persistence in 60% of the patients and 69.1% of the patients described their period of complaint in terms of years at the time of admission. The most frequent hair disorders were androgenetic alopecia (AGA) (45.8%), telogen effluvium (39.4%) and alopecia areata (17.8%). Trichoscopic examination was used in 339 patients (20.9%) and characteristic trichoscopic features contributed to the diagnosis in 85% of them. Conclusion: In our region, admissions due to hair problems have an important ratio among general outpatient clinic visits. For the physicians, being better informed about AGA, telogen effluvium and alopecia areata and being able to perform trichoscopy as the diagnostic modality will increase the success in the diagnosis ...

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Comorbidity profiles among patients with alopecia areata: The importance of onset age, a nationwide population-based study

Cited by 221 publications

References 44 publications

Childhood alopecia areata: A study of 89 patients

Childhood alopecia areata: A study of 89 patients

When is the Appropriate Time to do Hair Transplantation in Recalcitrant Alopecia Areata, or Never?

Experience of a Hair Disease Unit: Analysis of 1.617 Cases

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