Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study

Pinart, Mariona; Benet, Marta; Annesi‐Maesano, Isabella; Berg, Andrea von; Berdel, Dietrich; Carlsen, Karin C. Lødrup; Bindslev‐Jensen, Carsten; Eller, Esben; Fantini, Maria Pia; Lenzi, Jacopo; Gehring, Ulrike; Heinrich, Joachim; Hohmann, Cynthia; Just, Jocelyne; Keil, Thomas; Kerkhof, Marjan; Kogevinas, Manolis; Koletzko, Sibylle; Koppelman, Gerard H.; Kull, Inger; Lau, Susanne; Melén, Erik; Momas, Isabelle; Porta, Daniela; Postma, Dirkje S.; Rancière, Fanny; Smit, Henriëtte A.; Stein, Renato T.; Tischer, Christina; Torrent, Maties; Wickman, Magnus; Wijga, Alet H.; Bousquet, Jean; Sunyer, Jordi; Basagaña, Xavier; Guerra, Stefano; Garcia‐Aymerich, Judith; Antó, Josep M.

doi:10.1016/s2213-2600(13)70277-7

Cited by 266 publications

(296 citation statements)

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“…The present work is a major extension of previous collaborative work regarding air pollution and asthma within the same cohorts 9 : longitudinal analyses were performed instead of cross-sectional analyses, making full use of the repeated measurements; associations were studied with incidence in addition to prevalence; the follow-up was extended to age [14][15][16] years; and pooled analyses in addition to cohort-specific analyses with subsequent metaanalyses were performed, resulting in particular in more precise estimates of age-specific effects. Our finding of an increase in asthma incidence with increasing levels of air pollution confirms earlier findings from other cohorts.…”

Section: Discussionmentioning

confidence: 99%

Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study

Gehring

Wijga

Hoek

et al. 2015

The Lancet Respiratory Medicine

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Section: Discussionmentioning

confidence: 99%

Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study

Gehring

Wijga

Hoek

et al. 2015

The Lancet Respiratory Medicine

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199

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“…Several studies have shown that atopic dermatitis is positively associated with asthma. [7][8][9] The risk of developing asthma among children with atopic dermatitis was shown to be increased by 2 compared with children with no atopic dermatitis.…”

Section: Main Outcomes and Measuresmentioning

confidence: 99%

Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood

et al. 2017

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and the PASTURE study group IMPORTANCE Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking.OBJECTIVE To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether some subtypes are more at risk for developing other allergic diseases. DESIGN, SETTING, AND PARTICIPANTSThe Protection Against Allergy Study in Rural Environments (PASTURE) is a European birth cohort where pregnant women were recruited between August 2002 and March 2005 and divided in 2 groups dependent on whether they lived on a farm. Children from this cohort with data on atopic dermatitis from birth to 6 years of age were included.EXPOSURES Atopic dermatitis, defined as an itchy rash on typical locations from birth to 6 years. MAIN OUTCOMES AND MEASURESThe latent class analysis was used to identify subtypes of atopic dermatitis in childhood based on the course of symptoms. Multivariable logistic regressions were used to analyze the association between atopic dermatitis phenotypes and other allergic diseases. RESULTSWe included 1038 children; of these, 506 were girls. The latent class analysis model with the best fit to PASTURE data separated 4 phenotypes of atopic dermatitis in childhood: 2 early phenotypes with onset before age 2 years (early transient [n = 96; 9.2%] and early persistent [n = 67; 6.5%]), the late phenotype with onset at age 2 years or older (n = 50; 4.8%), and the never/infrequent phenotype (n = 825; 79.5%), defined as children with no atopic dermatitis. Children with both parents with history of allergies were 5 times more at risk to develop atopic dermatitis with an early-persistent phenotype compared with children with parents with no history of allergies. Both early phenotypes were strongly associated with food allergy. The risk of developing asthma was significantly increased among the early-persistent phenotype (adjusted odds ratio, 2.87; 95% CI, 1.31-6.31). The late phenotype was only positively associated with allergic rhinitis. CONCLUSIONS AND RELEVANCEUsing latent class analysis, 4 phenotypes of atopic dermatitis were identified depending on the onset and course of the disease. The prevalence of asthma and food allergy by 6 years of age was strongly increased among children with early phenotypes (within age 2 years), especially with persistent symptoms. These findings are important for the development of strategies in allergy prevention.

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“…21 Wheeze was defined as at least 1 episode of wheeze during the 12 months before the date of the questionnaire.…”

Section: Defi Nition Of Respiratory Symptomsmentioning

confidence: 99%

Lung Function at 8 and 16 Years After Moderate-to-Late Preterm Birth: A Prospective Cohort Study

et al. 2016

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Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study

Cited by 266 publications

References 50 publications

Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study

Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study

Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood

Lung Function at 8 and 16 Years After Moderate-to-Late Preterm Birth: A Prospective Cohort Study

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