Comorbidity of chronic heart failure and chronic obstructive pulmonary disease: features of pathogenesis, clinic and diagnostics

Abstract

This article discusses the epidemiology of chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD). CHF and COPD are characterized by high prevalence and high mortality, especially when they are combined. The article analyzes the general mechanisms of formation of these diseases: the relationship of COPD with cardiovascular diseases is explained by common risk factors, including smoking, physical inactivity, improper feeding and genetic predisposition. The leading role in the pathogenesis of pathologies is played by the activation and maintenance of systemic inflammation. Article presents the features of the clinical picture and the direction of the diagnostics in case of suspected combined pathology, the possibilities of modern laboratory and instrumental research methods. Diagnostics of comorbidity of CHF and COPD may be difficult, given the above common risk factors, some common pathogenesis mechanisms and similar clinical symptoms. However the caution regarding the comorbidity of the studied conditions, as well as a thorough clinical examination and the appointment of the necessary additional research methods, can reduce the number of diagnostic mistakes and improve the prognosis in such patients.

Level and correlations of soluble suppression of tumorigenicity 2 protein in heart failure and its relationship with clinical and paraclinical characteristics of patients

“…Наиболее важна роль рассматриваемого белка-рецептора в диагностике ХСНсФВ, т.к. значимую роль в развитии данной формы заболевания играет системное воспаление, индуцируемое сопутствующими патологиями, такими как сахарный диабет, ожирение и артериальная гипертензия [9,10]. Отдельный интерес представляет роль ожирения в вопросах использования sST2 и NT-proBNP с диагностической целью.…”

Cardiac Biomarkers of High Risk of Complications and Death in Patients with SARS-COV-2 and CHF

“…In a study by Selda Murat et al of patients with HF, high DFR at admission was more specific in predicting clinical outcomes than D-dimer and fibrinogen. [17,18]. In their study, the high DFR value was significantly correlated with biomarkers that determine the prognosis of both inflammation and disease, such as procalcitonin, lactate, troponin, and ferritin.…”

Diagnostic and Prognostic Role of Cardiotrophin-1 in Patients with Heart Failure

“…It is known that IL-6 is an intercellular interaction protein (cytokine) secreted during inflammation [7]. Its secretion is regulated according to the principle of positive feedback by catecholamines, the concentration of which in the blood of patients with CHF is significantly increased due to the activation of the sympathoadrenal system.…”