Comorbidity of autism with hyperkinetic disorder

Abstract

IntroductionAutism spectrum disorders encompass a heterogeneous group of neurodevelopmental disorders. Autism may be accompanied by other mental and neurological disorders. Comorbidity in autism is the rule rather than the exception (as reflected in DSM-5).ObjectivesTo study comorbidity in patients with childhood autism and hyperkinetic disorder.MethodsSurveyed 102 patients aged 6–7 years who had infantile psychosis before the age of 3 years (F84.02), comorbid with hyperkinetic disorder (F90.0). Methods: clinical, psychological and psychometric (CARS, PEP, bfcrs, CGI, CPRS-R:S (parents’ form)).ResultsIn the surveyed patients, the autism level was 46 points according to CARS. Manifestations of hyperkinetic disorder in patients with F84.02 are found in 72%, which is associated with the severity of catatonic arousal (BFCRS 36 points). The cognitive development of the examined children is characterized by a combination of advancing, normative and delayed levels of development, depending on the type of cognitive dysontogenesis. Low indicators are revealed in involuntary attention, fine motor skills and hand-eye coordination. In patients with F84.02, a secondary hyperkinetic disorder forms upon exit from severe catatonia.ConclusionsExcessive motor activity is combined with impulsiveness and impaired attention in the period of remission. The use of a complex of clinical and psychodiagnostic techniques aimed at assessing voluntary and involuntary attention provides additional data for the diagnosis of ASD and hyperkinetic disorders.

Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats

“…Hyperactivity, impulsivity, aggression, self-injury, and irritability are disruptive behaviors that frequently accompany ASD [35]. Hyperkinesia was found in 72% of patients with ASD, and excessive exercise accompanies impulsivity and attention deficits over time [36]. ADHD is one of the most common mental disorders in children, and ADHD and ASD have common genetic factors [11,37].…”

Febrile seizure in infants underlies endophenotypes of autism spectrum disorder in rats

“…Hyperactivity, impulsivity, aggression, self-injury, and irritability are disruptive behaviors that frequently accompany ASD [69]. Hyperkinesia was found in 72% of patients with ASD, and excessive exercise accompanies impulsivity and attention de cits over time [70]. ADHD is one of the most common mental disorders in children, and ADHD and ASD have common genetic factors [22,55].…”