Comorbidity of atopic diseases and gastro‐oesophageal reflux: evidence of a shared cause

Brew, Bronwyn K.; Almqvist, Catarina; Lundholm, Cecilia; Andréasson, Anna; Lehto, Kelli; Talley, Nicholas J.; Gong, Tong

doi:10.1111/cea.14106

Cited by 4 publications

(4 citation statements)

References 48 publications

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“…In a Swedish twin study, the risk of GERD in study participants with asthma was OR 1.52 but additional analyses found no differences in comorbidity estimates for asthma diagnosed in childhood or adulthood 32. In our study, risk of having GERD was OR 2.05 among people with asthma compared with non-asthmatics.…”

Section: Discussioncontrasting

confidence: 64%

Comorbidities associated with adult asthma: a population-based matched cohort study in Finland

Lemmetyinen,

Toppila-Salmi,

But

et al. 2024

BMJ Open Resp Res

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BackgroundAsthma is a common chronic disease characterised by variable respiratory symptoms and airflow limitation, affecting roughly 4%–10% of the adult population. Adult asthma is associated with higher all-cause mortality compared to individuals without asthma. In this study, we investigate the comorbidities that may affect the management of asthma.MethodsTotal of 1648 adults with asthma and 3310 individuals without asthma aged 30–93 were matched with age, gender and area of residency, and followed from 1 January 1997 to 31 December 2013. Baseline information was collected with questionnaires 1997 and follow-up register data from the national discharge registry Finnish Institute for Health and Welfare. Data included diagnoses from outpatient care and day surgery of specialised health care, and data from inpatient care of specialised and primary health care. We included all main diagnoses that had at minimum 200 events and number of diagnoses based on their common appearance with adult asthma.ResultsThe mean follow-up time varied between 14.2 and 15.1 years, and age at the time of enrolment was 53.9 years for subjects without asthma and 54.4 years for patients with asthma. Chronic obstructive pulmonary disease was 10 times more common among asthmatics. Risk of acute rhinosinusitis, chronic rhinosinusitis with nasal polyps, atopic dermatitis and vocal cord dysfunction was fourfold and risk of pneumonia, and chronic rhinosinusitis was 2.5 times more common among asthmatics. Sleep apnoea, gastro-oesophageal reflux disease, diabetes, allergic rhinitis and dysfunctional breathing were twofold and cataract nearly twofold higher in the asthmatic group. Adult asthma was also significantly associated with musculoskeletal diseases, incontinence and bronchiectasis.ConclusionsThe most common and most severe comorbidity of adult asthma in this study was chronic obstructive pulmonary disease. Other common comorbidities of adult asthma include acute rhinosinusitis, chronic rhinosinusitis with nasal polyps, atopic dermatitis, allergic rhinitis, dysfunctional breathing, diabetes, pneumonia, sleep apnoea and gastro-oesophageal reflux disease.

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Section: Discussioncontrasting

confidence: 64%

Comorbidities associated with adult asthma: a population-based matched cohort study in Finland

Lemmetyinen,

Toppila-Salmi,

But

et al. 2024

BMJ Open Resp Res

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“…Conversely, Brew et al concluded that patients with AD are at risk of having GERD. In their large twin cohort, the odds of having GERD comorbidity in patients with AD were found to be OR 1.23 (95%CI 1.10-1.38) [82].…”

Section: Gastroesophageal Reflux Disease (Gerd)mentioning

confidence: 99%

“…Furthermore, they proposed that a shared component involving affective traits, such as neuroticism, depression, or anxiety, may play a role. They implied that having an atopic disease may increase the risk of depression, anxiety, or neuroticism, which in turn triggers GERD [82]. Undoubtedly, further research is needed to establish the relationship between AD and GERD.…”

Section: Gastroesophageal Reflux Disease (Gerd)mentioning

confidence: 99%

Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative Review

Zysk,

Mesjasz,

Trzeciak

et al. 2024

IJMS

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The current understanding of atopic dermatitis (AD) seems to be extending beyond a skin-confined condition frequently associated with allergic comorbidities, as in a number of epidemiological studies, the prevalence rate of a range of illnesses has been determined to be greater in patients with AD, or inversely. In most cases, the reasons for this are vague. A subset of these conditions are gastrointestinal disorders, including food sensitization (FS) and food allergy (FA), eosinophilic esophagitis (EoE) (it is of mixed background, both IgE-dependent and independent), food protein-induced enterocolitis syndrome (FPIES) (it exemplifies an IgE-independent food allergy), Crohn’s disease (CD), colitis ulcerosa (CU), celiac disease, irritable bowel syndrome (IBS), and gastroesophageal reflux disease (GERD). In this review, we performed a comprehensive search of the literature using the PubMed database. We addressed the epidemiology of the increased co-occurrence of these diseases with AD and discussed potential causes for this subject. Multiple gastroenterological comorbidities appear to be more common in patients with AD, according to our review. The mechanisms that underlie this phenomenon are largely unknown, highlighting the need for further study in this field.

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“…However, it was suggested that a shared component, including emotional disorders, rather than a causal relationships may be significant. 45 Therefore, 2 possible mechanisms of action have been proposed: mediation, in which having an atopic disease increases the risk of depression, anxiety, or neuroticism which then trigger and exacerbate GERD; or a common cause, in which having depression, anxiety, or neuroticism increases vulnerability to developing or reporting both atopic diseases and GERD.…”

mentioning

confidence: 99%

Asthma and comorbidities: recent advances

Cazzola¹,

Rogliani²,

Ora³

et al. 2022

Polish Archives of Internal Medicine

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Comorbidity of atopic diseases and gastro‐oesophageal reflux: evidence of a shared cause

Cited by 4 publications

References 48 publications

Comorbidities associated with adult asthma: a population-based matched cohort study in Finland

Comorbidities associated with adult asthma: a population-based matched cohort study in Finland

Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative Review

Asthma and comorbidities: recent advances

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