Comorbidity in Older Patients Hospitalized with Cancer in Northeast China based on Hospital Discharge Data

Mu, Xiao-Min; Wang, Wei; Wu, Fangyi; Jiang, Yanni; Ma, Lingling; Feng, June

doi:10.3390/ijerph17218028

Cited by 10 publications

(11 citation statements)

References 37 publications

(42 reference statements)

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“…Overall, 77.5% of the patients had comorbidities, which was significantly higher than the results for the elderly population [43,44]. Moreover, the proportions of multiple comorbidities were up to 90%, which is consistent with previous studies [21]. Further, we determined lung cancer patients to have higher proportions of multiple comorbidities and that these comorbidities are complex.…”

Section: Discussionsupporting

confidence: 90%

“…The rapidly growing electronic medical records and epidemiological data have made it possible to conduct comprehensive comorbidity analyses. Lung cancer is the most common cancer and the leading cause of cancer-related deaths in China, especially in Northeast China [21]. In this paper, we present a study on identifying the comorbidity pattens of older lung cancer patients in Northeast China.…”

Section: Introductionmentioning

confidence: 99%

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Comorbidity Patterns of Older Lung Cancer Patients in Northeast China: An Association Rules Analysis Based on Electronic Medical Records

Feng

et al. 2020

IJERPH

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Purposes: This study aims to identify the comorbidity patterns of older men with lung cancer in China. Methods: We analyzed the electronic medical records (EMRs) of lung cancer patients over age 65 in the Jilin Province of China. The data studied were obtained from 20 hospitals of Jilin Province in 2018. In total, 1510 patients were identified. We conducted a rank–frequency analysis and social network analysis to identify the predominant comorbidities and comorbidity networks. We applied the association rules to mine the comorbidity combination with the values of confidence and lift. A heatmap was utilized to visualize the rules. Results: Our analyses discovered that (1) there were 31 additional medical conditions in older patients with lung cancer. The most frequent comorbidities were pneumonia, cerebral infarction, and hypertension. (2) The network-based analysis revealed seven subnetworks. (3) The association rules analysis provided 41 interesting rules. The results revealed that hypertension, ischemic cardiomyopathy, and pneumonia are the most frequent comorbid combinations. Heart failure may not have a strong implicating role in these comorbidity patterns. Cerebral infarction was rarely combined with other diseases. In addition, glycoprotein metabolism disorder comorbid with hyponatremia or hypokalemia increased the risk of anemia by more than eight times in older lung cancer patients. Conclusions: This study provides evidence on the comorbidity patterns of older men with lung cancer in China. Understanding the comorbidity patterns of older patients with lung cancer can assist clinicians in their diagnoses and contribute to developing healthcare policies, as well as allocating resources.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Comorbidity Patterns of Older Lung Cancer Patients in Northeast China: An Association Rules Analysis Based on Electronic Medical Records

Feng

et al. 2020

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“…Additionally, older people are vulnerable to secondhand smoke exposure and have a cumulative risk of exposure to secondhand smoke, so they are more affected by tobacco smoke after they have cancer. Also, older people commonly have other morbidities that exacerbate cancer prognosis ( 25 ). According to a report by the US Centers for Disease Control and Prevention, ~80% of adults aged ≥65 years have at least one chronic condition, and 50% have at least two chronic conditions ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, it is more likely for them to develop other NCDs because of changes in lifestyle behaviors, such as poor physical activity, which also increase cancer risk and trigger a greater disease burden ( 23 ). After cancer occurs in older people, they may be more fragile than younger people, and their health might deteriorate rapidly ( 25 ). The increasing burden in the older population has important implications for health policy, including protecting older people from carcinogenic risks, ensuring earlier cancer screening, and providing long-term supportive care for cancer ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Global trends and regional differences in the burden of cancer attributable to secondhand smoke in 204 countries and territories, 1990–2019

Maimaitiming

Wang²,

Luo³

et al. 2022

Front. Oncol.

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BackgroundTo describe the status quo and trends in the global burden of all cancers caused by secondhand smoke during 1990–2019.MethodsData on cancer associated with secondhand smoke were extracted from the Global Heath Data Exchange. Cancer burden was measured by cancer-related deaths, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs).ResultsIn 2019, age-standardized rates of death, DALYs and YLLs among the cancer population globally caused by secondhand smoke were 1.60, 38.54 and 37.77, respectively. The proportions of these in the total cancer burden for all risk factors combined decreased slightly from 1990 to 2003 and then increased from 2004 to 2019. In 2019, >50% of the cancer burden was concentrated in men aged 55–75 years and women aged 50–70 years. Between 1990 and 2019, there was an increase in age-standardized rates of death, DALYs, YLDs and YLLs among those aged ≥70 years. The age-standardized YLDs rate attributable to secondhand smoke was higher among women; it decreased in men but increased in women, causing a wider gap between the sexes. A greater cancer burden was mainly seen in North America in 1990 and Europe in 2019. Reductions in the annual rate change of cancer burden were found mainly in North America and Oceania, while increases were found in Africa and Asia. In 2019, high–middle- and middle-SDI countries had higher age-standardized rates of deaths, DALYs, YLDs and YLLs than the global level. During 1990 and 2019, the largest decline in cancer burden was seen in high-SDI countries, while middle- or low-SDI countries experienced increases in all age-standardized rates.ConclusionsCancer burden attributable to secondhand smoke is concerning given the increasing health loss and differences in distribution of cancer burden worldwide. Further studies are needed to investigate the causes of disparities in cancer burden attributable to secondhand smoke and to improve understanding of the contribution of secondhand smoke to the burden of different types of cancer.

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“…A case–control cohort study applied network-based analysis to explore the associations between multiple comorbidities of COPD [ 30 ]. Further, Mu et al [ 31 ] investigated the comorbidity patterns of hepatocellular carcinoma based on a comorbidity network.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic Disease Network Analysis to Identify Comorbidity Patterns in Hospitalized Patients with Ischemic Heart Disease Using Large-Scale Administrative Data

et al. 2022

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Ischemic heart disease (IHD) exhibits elevated comorbidity. However, few studies have systematically analyzed the comorbid status of IHD patients with respect to the entire spectrum of chronic diseases. This study applied network analysis to provide a complete picture of physical and mental comorbidities in hospitalized patients with IHD using large-scale administrative data. Hospital discharge records from a provincial healthcare database of IHD inpatients (n = 1,035,338) and one-to-one matched controls were included in this retrospective analysis. We constructed the phenotypic disease networks in IHD and control patients and further assessed differences in comorbidity patterns. The community detection method was applied to cluster diagnoses within the comorbidity network. Age- and sex-specific patterns of IHD comorbidities were also analyzed. IHD inpatients showed 50% larger comorbid burden when compared to controls. The IHD comorbidity network consisted of 1941 significant associations between 71 chronic conditions. Notably, the more densely connected comorbidities in IHD patients were not within the highly prevalent ones but the rarely prevalent ones. Two highly interlinked communities were detected in the IHD comorbidity network, where one included hypertension with heart and multi-organ failures, and another included cerebrovascular diseases, cerebrovascular risk factors and anxiety. Males exhibited higher comorbid burden than females, and thus more complex comorbidity relationships were found in males. Sex-specific disease pairs were detected, e.g., 106 and 30 disease pairs separately dominated in males and females. Aging accounts for the majority of comorbid burden, and the complexity of the comorbidity network increased with age. The network-based approach improves our understanding of IHD-related comorbidities and enhances the integrated management of patients with IHD.

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Comorbidity in Older Patients Hospitalized with Cancer in Northeast China based on Hospital Discharge Data

Cited by 10 publications

References 37 publications

Comorbidity Patterns of Older Lung Cancer Patients in Northeast China: An Association Rules Analysis Based on Electronic Medical Records

Comorbidity Patterns of Older Lung Cancer Patients in Northeast China: An Association Rules Analysis Based on Electronic Medical Records

Global trends and regional differences in the burden of cancer attributable to secondhand smoke in 204 countries and territories, 1990–2019

Phenotypic Disease Network Analysis to Identify Comorbidity Patterns in Hospitalized Patients with Ischemic Heart Disease Using Large-Scale Administrative Data

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