Comorbidity

Angold, Adrian; Costello, E. Jane; Erkanli, Alaattin

doi:10.1017/s0021963098003448

Cited by 596 publications

(828 citation statements)

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“…Similar findings have been replicated by analyses of data from other large samples (Krueger and Markon 2006;Lahey et al 2004). Confirmatory factor analysis is appropriate to study adolescent psychopathology as pure psychiatric disorders are rare and clusters of disorders often co-occur at rates greater than chance (Angold et al 1999). …”

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confidence: 61%

“…The first two-factor model (M2a) posits that the indicators for suicidality (SI and SA) load on one latent factor, that the indicators for psychopathology (MDE, PTSD, CD, AA, and DA) load on another latent factor, and that the latent factors are correlated. M2a has merit as there is evidence for comorbidity among psychiatric disorders (e.g., Angold et al 1999). The second two-factor model (M2b) suggests that the indicators for suicidality and internalizing (SI, SA, MDE, and PTSD) load on one latent factor, and it is related to an externalizing latent factor comprised of three indicators (CD, AA, and DA).…”

Section: Contributions Of the Present Studymentioning

confidence: 99%

“…First, we used lifetime reports of suicidality and psychopathology, and the results might be affected by recall biases (Angold et al 1999;Foley et al 2006). Also, lifetime reports of suicidality and psychiatric diagnoses, when compared to current or past-year measures, yield higher prevalence rates for individual and comorbid problems (Angold et al 1999;Foley et al 2006), which might strengthen the correlations (cf. Bonett and Price 2005).…”

Section: Weaknessesmentioning

confidence: 99%

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A Dimensional Model of Psychopathology Among Homeless Adolescents: Suicidality, Internalizing, and Externalizing Disorders

Yoder

Longley

Whitbeck

et al. 2007

J Abnorm Child Psychol

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The present study examined associations among dimensions of suicidality and psychopathology in a sample of 428 homeless adolescents (56.3% female). Confirmatory factor analysis results provided support for a three-factor model in which suicidality (measured with lifetime suicidal ideation and suicide attempts), internalizing disorders (assessed with lifetime diagnoses of major depressive episode and post-traumatic stress disorder), and externalizing disorders (indicated by lifetime diagnoses of conduct disorder, alcohol abuse, and drug abuse) were positively intercorrelated. The findings illustrate the utility of a dimensional approach that integrates suicidality and psychopathology into one model. KeywordsPsychopathology; Suicidality; Internalizing; Externalizing; Homeless adolescents Dimensions of adolescent suicidality and psychopathology are of increased concern to clinicians and researchers (Bridge et al. 2006;Verona et al. 2004). This interest can be attributed to the relatively high prevalence of adolescent suicidal ideation and suicide attempts (Evans et al. 2005) and to suicide being the third leading cause of death among youths ages 15-24 in the USA (Hoyert et al. 2006). Research also indicates both suicidal ideation and suicide attempts increase the risk for completed suicide (Brown et al. 2000). This pattern of increased liability for suicide risk has led to a broader conceptualization of a suicide spectrum ranging from suicidal ideation to attempted and completed suicide (Lewinsohn et al. 1996).Moreover, psychiatric disorders are among the strongest correlates of adolescent suicidality (Bridge et al. 2006). Mood disorders are robust correlates, but post-traumatic stress disorder, conduct disorder, and substance use disorders are also associated with suicidality (Bridge et al. 2006;Evans et al. 2004). Krueger (1999), informed by the work of Achenbach (Achenbach and McConaughy 1997), developed a dimensional model of psychopathology and clustered psychiatric diagnoses into internalizing and externalizing disorders. As specific psychiatric disorders from both clusters are related to suicidal ideation and attempts, there is interest in linking the suicide spectrum to these broader dimensions of psychopathology (Hills et al. 2005;Verona et al. 2004).Our study expands on this work by including the internalizing and externalizing dimensions of psychopathology in a structural model of adolescent suicidality using a sample of homeless adolescents. Suicidality is measured with lifetime suicidal ideation and suicide attempts, internalizing psychopathology with lifetime diagnoses of major depressive episode and posttraumatic stress disorder, and externalizing psychopathology with lifetime diagnoses of conduct disorder, alcohol abuse, and drug abuse. We use confirmatory factor analysis to examine covariances among dimensions of suicidality, internalizing, and externalizing disorders. Internalizing and Externalizing DisordersAchenbach used an empirical approach to derive two broad dimensions (internalizing...

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mentioning

confidence: 61%

Section: Contributions Of the Present Studymentioning

confidence: 99%

Section: Weaknessesmentioning

confidence: 99%

See 1 more Smart Citation

A Dimensional Model of Psychopathology Among Homeless Adolescents: Suicidality, Internalizing, and Externalizing Disorders

Yoder

Longley

Whitbeck

et al. 2007

J Abnorm Child Psychol

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“…The discovery that two or even more distinct psychiatric disorders jointly occur in one individual is very important, because psychiatric comorbidity often appears to connote greater impairment and chronicity [6]. Comorbidity often suggests poorer response to treatment and worse longitudinal trajectories [41].…”

Section: Introductionmentioning

confidence: 99%

Agreement between youth-reported and parent-reported psychopathology in a referred sample

Salbach‐Andrae

Klinkowski²,

Lenz³

et al. 2009

Eur Child Adolesc Psychiatry

137

101

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Objective: The study examined parent-youth agreement regarding reports on psychopathology among adolescents suffering from psychiatric disorders. Method: A total of 1,718 patients between the age of 11 and 18, as well as their parents, were assessed using the child behavior checklist (CBCL), and the youth self-report (YSR). Results: Poor to low agreement between parent- and adolescent-reported problem behavior on the internalizing scale, the total problem scale and moderate agreement concerning the externalizing scale of the CBCL and the YSR were found. Independent from the amount of psychiatric diagnoses, adolescents reported significantly less behavioral problems than their parents. Concerning externalizing problems, parent-youth disagreement was stronger for patients suffering from comorbid psychiatric disorders, than for adolescents displaying only one psychiatric disorder. Conclusion: In clinically referred children, parents are likely to emphasize the severity of the difficulties, whereas adolescents’ under-report symptoms

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“…Simonoff et al (2008) found that ß28% of school-aged children with ASD also fulfill DSM-IV criteria for ADHD and 9% for chronic tic disorder. A meta-analysis of ADHD yielded a 10.7-fold risk for conduct disorder, 5.5-fold for depression, and 3.0-fold for anxiety disorder (Angold et al, 1999).…”

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confidence: 99%

The Roots of Autism and ADHD Twin Study in Sweden (RATSS)

et al. 2014

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Neurodevelopmental disorders affect a substantial minority of the general population. Their origins are still largely unknown, but a complex interplay of genetic and environmental factors causing disturbances of the central nervous system's maturation and a variety of higher cognitive skills is presumed. Only limited research of rather small sample size and narrow scope has been conducted in neurodevelopmental disorders using a twin-differences design. The Roots of Autism and ADHD Twin Study in Sweden (RATSS) is an ongoing project targeting monozygotic twins discordant for categorical or dimensional autistic and inattentive/hyperactive-impulsive phenotypes as well as other neurodevelopmental disorders, and typically developing twin controls. Included pairs are 9 years of age or older, and comprehensively assessed for psychopathology, medical history, neuropsychology, and dysmorphology, as well as structural, functional, and molecular brain imaging. Specimens are collected for induced pluripotent (iPS) and neuroepithelial stem cells, genetic, gut bacteria, protein-/monoamine, and electron microscopy analyses. RATSS's objective is to generate a launch pad for novel surveys to understand the complexity of genotype-environment-phenotype interactions in autism spectrum disorder and attention-deficit hyperactivity disorder (ADHD). By October 2013, RATSS had collected data from 55 twin pairs, among them 10 monozygotic pairs discordant for autism spectrum disorder, seven for ADHD, and four for other neurodevelopmental disorders. This article describes the design, recruitment, data collection, measures, collected pairs’ characteristics, as well as ongoing and planned analyses in RATSS. Potential gains of the study comprise the identification of environmentally mediated biomarkers, the emergence of candidates for drug development, translational modeling, and new leads for prevention of incapacitating outcomes.

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Comorbidity

Cited by 596 publications

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A Dimensional Model of Psychopathology Among Homeless Adolescents: Suicidality, Internalizing, and Externalizing Disorders

A Dimensional Model of Psychopathology Among Homeless Adolescents: Suicidality, Internalizing, and Externalizing Disorders

Agreement between youth-reported and parent-reported psychopathology in a referred sample

The Roots of Autism and ADHD Twin Study in Sweden (RATSS)

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