Comorbidities of Refractory Epilepsy and the Update Mechanism

Wang, Xiongfei; He, Xiuli; Luan, Guoming

doi:10.4172/neuropsychiatry.1000s1007

Cited by 2 publications

(3 citation statements)

References 41 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is evidenced by transgenic overexpression of ADK in the brain of mice (Adk-tg mice) caused prominent cognitive impairment on several levels [31,32]. In clinical practice, cognitive deficits, or mental retardation, may be considered as one of most common comorbidities of refractory epilepsy, especially for children [3,33]. Our recent study has demonstrated that vagus nerve stimulation (VNS) or deep brain stimulation (DBS) might improve neuropsychological outcomes, including language, memory, perception [34,35].…”

Section: Discussionmentioning

confidence: 99%

Overexpression of Adenosine Kinase in Patients with Epilepsy Associated With Sturge-Weber Syndrome

Luan¹,

Wang²,

Chen³

et al. 2018

Neuropsychiatry

Self Cite

View full text Add to dashboard Cite

Background: The Sturge-Weber syndrome (SWS), a vascular disorder with leptomeningeal capillary-venous malformations, is thought to be caused by somatic mutations in the GNAQ gene. However, the relationship between SWS and epileptogenesis is still unknown. Overexpression of adenosine kinase (ADK) has been regarded as a pathologic hallmark of epilepsy. We hypothesize that abnormal expression of ADK, may play an important role in epileptogenesis of SWS patients with refractory epilepsy.

show abstract

Section: Discussionmentioning

confidence: 99%

Overexpression of Adenosine Kinase in Patients with Epilepsy Associated With Sturge-Weber Syndrome

Luan¹,

Wang²,

Chen³

et al. 2018

Neuropsychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…The term "co morbidity" refers to one or more other disease among people with an index disease 6 .With the reconceptualization of epilepsy as a disease of brain network, it is great timing to rethink epilepsy and those associated comorbidities, including cognitive and behavioral co morbidities, psychiatric co morbidities, cardiovascular disease and migraines 1 .The epilepsy associated co morbidities are often underestimated, consequently, undertreated. Furthermore, cognitive deficits always remain despite seizure greatly control 7 .…”

Section: Original Article Open Accessmentioning

confidence: 99%

“…Epilepsy is still an issue that perplexes the epileptologists worldwide, with a reported impact on 50 million populations 1 . Seizures affect 4-7% of children 2 .…”

Section: Introductionmentioning

confidence: 99%

Neurodevelopmental Co morbidities of Poorly-Controlled Childhood Epilepsy: A Case-Control Study

Asaduzzaman¹,

Rahman

Hasan³

2021

Med. Today

View full text Add to dashboard Cite

Introduction: The epilepsy associated co morbidities are often underestimated, consequently, undertreated. The aim of the present study was to determine neurodevelopmental co morbidities associated with poorly controlled childhood epilepsy. Materials and Methods: This retrospective study was performed from January 2007 to December 2008 at Paediatric Neurology outpatient department in Bangabandhu Sheikh Mujib Medical University, Dhaka, among the children with epilepsy of 7 months to 15 years age who had history of at least 6 months treatment with rational antiepileptic drugs daily with adequate compliance. There were two groups of patients; group 1, consisted of 50 poorly controlled epilepsy patients and group 2, comprised 50 well-controlled epilepsy patients. We retrospectively reviewed EEGs and medical records from these children. Features of neurolodevelopmental co morbidities were compared between the two groups. Results: In this study, initial EEG was abnormal significantly in poorly controlled group (OR= 5.27; p=0.025). Co morbidities- cerebral palsy, language and speech delay, motor delay, microcephaly and cognitive disability were significantly higher in poorly-controlled epilepsy group compared to well-controlled epilepsy group (60.0% vs. 24.0%, p <0.001; 74.0% vs. 38%, p <0.001; 72% vs. 40%, p <0.01; 60% vs. 30.0%, p <0.01; 70% vs 32%, p <0.001 respectively). Conclusion: The study showed several neurodevelopment co morbidities that can be identified early in the course of childhood epilepsy which can predict development of poor seizure control. Knowledge of these co morbidities will help us to discriminate our patient and can inform therapeutic choices. Medicine Today 2021 Vol.33(1): 65-70

show abstract

Comorbidities of Refractory Epilepsy and the Update Mechanism

Cited by 2 publications

References 41 publications

Overexpression of Adenosine Kinase in Patients with Epilepsy Associated With Sturge-Weber Syndrome

Overexpression of Adenosine Kinase in Patients with Epilepsy Associated With Sturge-Weber Syndrome

Neurodevelopmental Co morbidities of Poorly-Controlled Childhood Epilepsy: A Case-Control Study

Contact Info

Product

Resources

About