Comorbidities of Prurigo Nodularis in Finland Between 1996 and 2019

Wikström, K; Verkko, Henri; Sinikumpu, Suvi‐Päivikki; Jokelainen, Jari; Tasanen, Kaisa; Huilaja, Laura

doi:10.2340/00015555-3872

Cited by 6 publications

(23 citation statements)

References 14 publications

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“…18 In addition, our finding about depression and anxiety in LP patients is comparable to psychiatric morbidity overall among adult patients with another itching skin disease, prurigo nodularis, in Finland. 19 However, the prevalences in our study were not as high as in the recent meta-analysis. 17 This can arise, for example, from the different study design and the fact that the metaanalysis also included cases of pure oral LP, and those with oral LP have been described to have higher risk of depression than cases with cutaneous LP.…”

Section: Discussioncontrasting

confidence: 95%

“…Thus, there was more depression among LP patients than in general Finnish population (12.0% among those aged 45–54 years and 7.0% in those aged 55–64 years, respectively) 18 . In addition, our finding about depression and anxiety in LP patients is comparable to psychiatric morbidity overall among adult patients with another itching skin disease, prurigo nodularis, in Finland 19 . However, the prevalences in our study were not as high as in the recent meta‐analysis 17 .…”

Section: Discussionsupporting

confidence: 54%

See 1 more Smart Citation

Characteristics, comorbidities, and treatment practices of lichen planus in Northern Finland: A register‐based study among 619 subjects

Anttonen,

Pöykkö,

Kiviniemi

et al. 2023

Health Science Reports

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Background and Aims Lichen planus (LP) is a common itching skin disease where lesions appear on the skin and mucous membranes. However, the epidemiology of LP is not yet sufficiently understood. The aim of this study was to retrospectively map out the characteristics, comorbidities and treatments of patients diagnosed with LP. Methods This is a retrospective hospital patient registry‐based study performed between 2009 and 2021 in a secondary care hospital (Oulu University Hospital) in Northern Finland. All patients with recorded diagnosis of LP were included in the study. Characteristics, comorbidities, and treatments of LP patients were studied. Results In total, 619 patients were verified from the hospital health records. The mean age of patients was 54.2 years and the majority were female (58.3%). Most of the patients had symptoms in more than two skin areas (mean 2.7 skin areas), lower limbs being the most common site (74.0%). A third of patients (34.7%) had oral LP lesions. Nearly fifth (19.4%) of the subjects had a history of previous LP. Of comorbidities found among LP subjects, obesity (22.5%), malignancies (19.4%), depression (12.8%), and thyroiditis (12.4%) were seen more often than in general Finnish population. The most used form of treatment was topical corticosteroids (97.6%), followed by phototherapy 26.8%. Systemic treatments such as prednisolone and methotrexate had been used in 7.6% and 1.1% of the patients, respectively. Conclusion LP patients had a heightened risk for several comorbidities, which should be considered when managing patients with LP.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionsupporting

confidence: 54%

Characteristics, comorbidities, and treatment practices of lichen planus in Northern Finland: A register‐based study among 619 subjects

Anttonen,

Pöykkö,

Kiviniemi

et al. 2023

Health Science Reports

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“…A similar study in the USA showed that patients with prurigo nodularis had a higher burden of several cardiovascular, pulmonary and other systemic diseases than those with atopic dermatitis and those with psoriasis 28 . A study of 223 patients from Finland also found frequent cardiovascular, respiratory, psychiatric or endocrine comorbidities 29 . A Korean study found that prurigo nodularis was associated with chronic kidney disease (adjusted odds ratio 1·48), dyslipidemia (1·88), type 2 diabetes mellitus (1·37), arterial hypertension (1·50), autoimmune thyroiditis (2·43), non‐Hodgkin lymphoma (1·95) and atopic dermatitis (2·16) 30 …”

Section: Epidemiologymentioning

confidence: 91%

“…28 A study of 223 patients from Finland also found frequent cardiovascular, respiratory, psychiatric or endocrine comorbidities. 29 A Korean study found that prurigo nodularis was associated with chronic kidney disease (adjusted odds ratio 1Á48), dyslipidemia (1Á88), type 2 diabetes mellitus (1Á37), arterial hypertension (1Á50), autoimmune thyroiditis (2Á43), non-Hodgkin lymphoma (1Á95) and atopic dermatitis (2Á16). 30 Higher frequency and higher severity were shown in African Americans by comparison with other parts of the US population.…”

Section: Epidemiologymentioning

confidence: 99%

Chronic prurigo

Miséry

2022

British Journal of Dermatology

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Chronic prurigo is a distinct disease defined by the presence of chronic pruritus for at least 6 weeks, a history and/or signs of repeated scratching, and multiple localized or generalized pruritic skin lesions (whitish or pinkish papules, nodules and/or plaques). Although chronic prurigo is frequently named prurigo nodularis, the nodular type of chronic prurigo is only the main clinical aspect of chronic prurigo. Chronic prurigo occurs due to neural sensitization to pruritus and the development of a vicious pruritus-scratching cycle. Chronic prurigo can be of allergological, dermatological, systemic, neurological, psychiatric/psychosomatic, mixed or undetermined origin. The prevalence is still debated. The burden is high. Current treatments often remained disappointing. Fortunately, recent research results on the pathophysiology of pruritus evidenced neuroimmune interactions and allow new therapeutic perspectives. Among them, antagonists of T-helper 2 cytokines, j-opioids and Janus kinase inhibitors may be promising.a Definition of pruriginous lesion: excoriated, scaling and/or crusted papules and/or nodules and/or plaques, often with a whitish or pink centre and hyperpigmented border.

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“…PN is accompanied by persistent itching and is thought to develop from repetitive scratching ( 5 ) in patients with chronic pruritus from various causes ( 6 ). Epidemiological studies have determined PN to coexist with chronic liver disease, HIV, and type 2 diabetes mellitus (DM), among other diseases ( 1 , 4 , 7 , 8 ), but the aetiological significance of the relationship is not known. An increased prevalence of PN has been observed in patients undergoing dialysis ( 9 , 10 ).…”

mentioning

confidence: 99%

Impact of Chronic Kidney Disease Severity on the Risk of Prurigo Nodularis: A Population-Based Cohort Study

Kim

Ahn³

2022

Acta Derm Venereol

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While dialysis is linked with prurigo nodularis, little is known about the impact of non-dialysis chronic kidney disease on prurigo nodularis. The influence of chronic kidney disease on development of prurigo nodularis was measured using the Korean National Health Insurance and National Health Screening Program data, identifying 17,295,576 individuals without prior prurigo nodularis. Chronic kidney disease severity was determined by the estimated glomerular filtration rate (in ml/min/1.73 m2) calculated from serum creatinine, and proteinuria detected with urine dipstick. Prurigo nodularis incidence during follow-up was determined. Over a median follow-up period of 9.72 years, 58,599 individuals developed prurigo nodularis, with an incidence rate of 3.59 per 10,000 person-years. Among different variables, estimated glomerular filtration rate was the strongest risk factor for prurigo nodularis. Compared with estimated glomerular filtration rate ≥ 90, estimated glomerular filtration rate 15–29 (hazard ratio 1.31, 95% confidence interval 1.05–1.62) and end-stage renal disease (hazard ratio 1.46, 95% confidence interval 1.25–1.69) were associated with higher risks. The presence of proteinuria independently increased the risk of prurigo nodularis, increased risks associated with estimated glomerular filtration rate 15–29 and end-stage renal disease, and caused risk associated with estimated glomerular filtration rate 30–59 to become significant. With differential impact of chronic kidney disease severity on the risk of prurigo nodularis, preservation of renal function would potentially translate into lower risk of prurigo nodularis.

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Comorbidities of Prurigo Nodularis in Finland Between 1996 and 2019

Cited by 6 publications

References 14 publications

Characteristics, comorbidities, and treatment practices of lichen planus in Northern Finland: A register‐based study among 619 subjects

Characteristics, comorbidities, and treatment practices of lichen planus in Northern Finland: A register‐based study among 619 subjects

Chronic prurigo

Impact of Chronic Kidney Disease Severity on the Risk of Prurigo Nodularis: A Population-Based Cohort Study

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