Comorbidities of Myasthenic Crisis Patients According to Age and Gender in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia in 2017-2019

Alfaidin, Andi Muh Rahul; Kalanjati, Viskasari Pintoko; Basuki, Mudjiani

doi:10.20473/mbiom.v32i1.2022.1-5

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…The annual prevalence of MG is 72 cases per 1 000 000 population, with an incidence rate of roughly 0.25–2 cases per 1 000 000 people 4 . According to basic health study reports, the incidence of MG in Indonesia is estimated to be 1 case in 100 000 5 , 6 .…”

Section: Introductionmentioning

confidence: 99%

Correlation of fatigue on walking ability in myasthenia gravis patients: a cross-sectional study

Kartika,

Subadi,

Pawana

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction: Myasthenia gravis (MG) is a neuromuscular junction autoimmune disease characterised of intermittent muscle weakness that increases with activity and recovers with rest. Objective: Analysing the correlation of fatigue on walking ability in MG patients. Methods: This study used a cross-sectional design with consecutive sampling. Participants MG patients took in this trial. Data collection encompasses fatigue and walking ability, with fatigue being assessed using the fatigue severity scale (FSS) and walking ability being assessed using the 10-metre walking test. The 10-metre walking test assessment contains three components: comfortable walking speed (CWS), maximum walking speed (MWS), and natural cadence. The statistical analysis used in this study includes the Pearson correlation and Spearman rank tests with P<0.05. Results: The number of participants was 23 MG patients, and most of the participant was female (69.6%). The participant’s fatigue value was 5.46±1.13, including MGFA 1=5.32±1.15, MGFA 2A=5.5±1.11, and MGFA 2B=5.61±1.30. Meanwhile, the participant’s walking abilities included CWS of 1.10±0.11 m/s, MWS of 1.31±0.15 m/s, and natural cadence of 110.91±7.74 steps/min. No significant correlation of fatigue on walking ability including FSS vs. CWS (r=−0.141; P=0.520), FSS vs MWS (r=−0.169; P=0.442), and FSS vs. natural cadence (r=−0.050; P=0.822). Conclusion: There was no significant correlation between fatigue and walking ability in MG patients who had MGFA 1, MGFA 2A, and MGFA 2B.

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Section: Introductionmentioning

confidence: 99%

Correlation of fatigue on walking ability in myasthenia gravis patients: a cross-sectional study

Kartika,

Subadi,

Pawana

et al. 2023

Annals of Medicine &Amp; Surgery

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“…The reported mortality rate due to myasthenic crisis is about 5% of cases. 3,4 Approximately 15%-20% of people with myasthenia gravis will experience at least one crisis attack during their lifetime. Patients in crisis require endotracheal intubation.…”

Section: Introductionmentioning

confidence: 99%

Critical Care Management of Myasthenic Crisis: A Case Report

Kahar

2023

Ina J Rheum

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Background: The annual incidence of myasthenia gravis is 1-2 cases in 100,000 population. 30% of all cases will develop bulbar or respiratory muscle weakness. About 15-20% of myasthenia gravis patients will develop myasthenia crisis. Case presentation: An 18-year-old female patient complained of difficulty swallowing two days ago difficulty swallowing solid and liquid food, and this complaint caused the patient to cough and choke. Complaints were accompanied by difficulty opening the eyelids, especially in the afternoon. Complaints were also accompanied by double vision, especially when looking to the right. There was a nasal sound, and the patient had difficulty pronouncing vocal letters. The patient was admitted to ICU, In the ICU patient was intubated and given plasma exchange therapy. Conclusion: Myasthenic crisis is a neurological emergency that requires prompt diagnosis and treatment. Adequate intensive care, judicious weaning, and extubation decisions, along with specifically targeted therapy, will improve the outcome of myasthenia gravis.

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Autoimmune and Non-Autoimmune Comorbidities in Myasthenic Patients of East-European Descent: A Case–Control Study

Croitoru,

Pavel-Tanasa,

Cuciureanu

et al. 2024

JCM

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Background: As the life expectancy of patients with myasthenia gravis (MG) is improving, so the number of comorbidities continues to rise, with a potentially significant impact on the overall morbidity and mortality. The main aim of the study was to assess comorbidities of MG in a group of patients of East-European descent. Methods: We retrospectively compared 185 adult myasthenic patients with 895 sex- and age-matched controls, admitted from January 2013 to December 2021. Results: Of these patients, 60% had late-onset MG (LOMG), with a clear predominance of women in both the LOMG and early-onset (EOMG) types; and 23.8% of the patients had a radiological description consistent with thymoma. All myasthenic patients had at least one comorbidity; 20 (10.8%) of the patients associated at least one autoimmune comorbidity. Obesity (p < 0.01), type 2 diabetes (p < 0.0001), cerebrovascular diseases (p < 0.0001), essential hypertension (p < 0.01), and cardiac arrythmias (p < 0.0001) were more frequent in patients than in the control group. The granulocyte-to-lymphocyte ratio was higher in the myasthenic patients compared to the controls (p < 0.01 for LOMG). Discussion: We, thus, suggest a common chronic low-grade inflammatory background as a possible connection between MG subtypes and some of these apparently unconnected comorbidities. Conclusions: The East-European origin of the patients offered a different social and cultural angle of a disease studied mainly on populations of West-European and Asian descent.

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Comorbidities of Myasthenic Crisis Patients According to Age and Gender in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia in 2017-2019

Cited by 3 publications

References 13 publications

Correlation of fatigue on walking ability in myasthenia gravis patients: a cross-sectional study

Correlation of fatigue on walking ability in myasthenia gravis patients: a cross-sectional study

Critical Care Management of Myasthenic Crisis: A Case Report

Autoimmune and Non-Autoimmune Comorbidities in Myasthenic Patients of East-European Descent: A Case–Control Study

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