Comorbidities of COPD in Bulgarian Patients – Prevalence and Association with Severity and Inflammation

Stratev, Velin; Petkova, Valentina; Dimitrova, Valentina; Petev, Jordan

doi:10.1515/folmed-2017-0078

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…Smith et al (22) noted that hyperlipidemia, hypertension and anxiety were the most common comorbidities, while Miyazaki et al found that HT (36%) to be the most prevalent, closely followed by GER (34%) and cardiac diseases (32%) (23). Stratev et al, on the other hand, found that the most common comorbidities were HT (70.4%), heart failure (47.4%), IHD (37.5%) and DM (21.4%) (24). In their study on 739 COPD patients, Koskela et al found that HT (41%) was the most common comorbidity, followed by chronic psychiatric conditions (33%), heart disease (22%) and DM (15%) (3).…”

Section: Discussionmentioning

confidence: 99%

Influence of comorbidities in long-term survival of chronic obstructive pulmonary disease patients

Eroğlu¹,

Günen²,

Yakar

et al. 2019

J. Thorac. Dis

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Background: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality and morbidity around the world, with comorbidities in COPD being common and having a negative effect on survival. We investigate the effects of comorbidities on long-term survival of COPD patients. Methods: The study included patients with COPD who were hospitalized with an exacerbation. The demographic characteristics, hematological and biochemical parameters, pulmonary function test parameters and comorbidities of the patients were obtained from the hospital database and patient records, and the mortality of the patients was assessed at two years. The parameters considered to be related to mortality were analyzed using the Cox regression method. Results: A total of 826 patients with COPD were included in the study, and the rate of patients with at least one comorbidity was 84.5%. The most common comorbidities were hypertension (n=394, 47.7%), heart failure (n=244, 29.5%) and DM (n=173, 20.9%). In a Cox regression analysis, the Charlson Comorbidity Index was strongly associated with mortality (P=0.000). In Kaplan-Meier analysis, a significant association was noted between the increasing number of comorbidities and long-term mortality, when compared to the patients without comorbidity (comorbidity numbers 1, 2 and ≥3; HR: 1.37, P=0.032, HR: 1.40, P=0.028 and HR: 1.65, P=0.000, respectively). Conclusions: Increasing number of comorbidities in COPD patients with severe exacerbation were found to negatively affect long-term survival. We consider both the evaluation and treatment of comorbidities to be important in the reduction of long-term mortality in patients with COPD.

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Section: Discussionmentioning

confidence: 99%

Influence of comorbidities in long-term survival of chronic obstructive pulmonary disease patients

Eroğlu¹,

Günen²,

Yakar

et al. 2019

J. Thorac. Dis

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“…Score ranges from 0 to 100, with higher scores indicating more limitations. In this study, the number of exacerbations per patient was compared to SGRQ score for evaluation [8][9][10].…”

Section: Methodsmentioning

confidence: 99%

A Study on the Effect of Exacerbations on the Quality of Life of Patients With Chronic Obstructive Pulmonary Disease

Kotha

Vasabhakthula

Undurthi

et al. 2020

World Journal of Current Med and Pharm Research

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Aim: The main aim of this study is to evaluate the effect of exacerbations on the quality of life of the patients with chronic obstructive pulmonary disease. Materials and Methods: Patients of both the genders and with an age of above 18 years of patients who were diagnosed with COPD were included in this prospective study. Modified British Medical Research Council (m-MRC) Dyspnoea Scale was used to establish functional impairment due to shortness of breath in the study participants. Saint George's Respiratory Questionnaire (SGRQ) was also used to assess the patient’s overall health and quality of life-based on self-report. Results: Among the 110 study participants, 87.3% were males and 12.7% were females. It was observed that majority of the patients were in the age group 51-60 years (43.6%). The most frequently observed co-morbidities were hypertension (22.7%) followed by diabetes mellitus (19.1%). Most of the patients were observed to be with m-MRC grade-3 (42.7%) followed by m-MRC garde-2 (39.1%). The SGRQ score was observed to be increased with increase in the frequency of exacerbations. Conclusion: Clinical Pharmacist should take the responsibility in providing effective evidence based therapeutic recommendations for the better management and well being of the COPD patients.

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“…Literature data [2] show that COPD is one of the predominant causes of death [8] with a global prevalence of up to 10.1% with an upward trend in the following decades [2]. It has been proven that COPD leads to significant disability [10] and is now the third leading cause of death in the world [11]. This pathology is a significant medical and social problem due to the high levels of mortality and disability of patients [10], especially due to its comorbidity with other diseases.…”

Section: Introductionmentioning

confidence: 99%

“…It has been proven that COPD leads to significant disability [10] and is now the third leading cause of death in the world [11]. This pathology is a significant medical and social problem due to the high levels of mortality and disability of patients [10], especially due to its comorbidity with other diseases. The most common comorbid conditions are cardiovascular pathology, diabetes mellitus, osteoporosis, chronic kidney disease, etc.…”

Section: Introductionmentioning

confidence: 99%

Laboratory and instrumental characteristics of patients with chronic obstructive pulmonary disease and hypertension

Tverezovskyi

2023

MTT

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The article defines the clinical-laboratory and clinical-instrumental features of the comorbid course of chronic obstructive pulmonary disease (COPD) and hypertension (HTN). The aim of the study was to determine the clinical, laboratory and instrumental features of the comorbid course of COPD and HTN. The study was carried out in accordance with the existing recommendations of bioethical norms and rules. All patients took part in the study of their own free will with the signing of informed consent. 125 patients aged 18–50 years were examined, who were divided into 3 groups: group I – 48 patients with COPD and HTN, group II – 47 patients with an isolated course of COPD, group III (control) – 30 practically healthy people. Medical and statistical calculation was performed using the IBM SPSS 25.0 software package. Calculated median (Me) levels and their 25.0% (LQ) and 75.0% (UQ) quartiles. The probability of differences was determined using the Man-Whitney U-test with a statistical significance threshold of 0.05 (p=0.05). According to the results of the study, an excess of systolic and diastolic blood pressure levels was significantly stated in comorbidity of COPD and HTN and in patients with isolated COPD. The presence of lymphocytopenia and monocytosis in such patients has been reliably established and significant protein loss in COPD has been determined. Significant predominances of biochemical values of the blood of patients with comorbidity of COPD and HNT and with isolated COPD compared to the control were significantly recorded. Significant decreases in the levels of external respiratory function in COPD (especially in its comorbidity with HNT) were noted and a significant predominance of Caspase-8 levels was determined in the following patients: in comorbidity of COPD and HTN – 3.79 [3.57; 3.84] U/l and in isolated COPD – 3.48 [2.99; 3.72] U/l. Keywords: patients with chronic obstructive pulmonary disease, comorbidity of arterial hypertension, clinical and laboratory characteristics, clinical and instrumental characteristics, caspase-8.

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Comorbidities of COPD in Bulgarian Patients – Prevalence and Association with Severity and Inflammation

Abstract: The present study suggests high prevalence of CVD comorbidities in COPD patients and association with the disease severity. Metabolic syndrome is a common comorbidity and is associated with increased inflammatory response.

Cited by 6 publications

References 26 publications

Influence of comorbidities in long-term survival of chronic obstructive pulmonary disease patients

Influence of comorbidities in long-term survival of chronic obstructive pulmonary disease patients

A Study on the Effect of Exacerbations on the Quality of Life of Patients With Chronic Obstructive Pulmonary Disease

Laboratory and instrumental characteristics of patients with chronic obstructive pulmonary disease and hypertension

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