Comorbidities of Chronic Obstructive Pulmonary Disease in Koreans: A Population-Based Study

Abstract

Chronic obstructive pulmonary disease (COPD) includes pulmonary components with increased comorbidity rates, as well as being a systemic disease. Comorbidities may frequently occur in COPD patients over 40 yr old. We report the comorbidities of patients with COPD, diagnosed by spirometry, in a population-based epidemiologic survey in Korea. Data were derived from the fourth Korean Health and Nutrition Examination Survey in 2008, a stratified multistage clustered probability design survey of a sample representing the entire population of Korea. Results of spirometry and various health-related questionnaires were analyzed in 2,177 subjects aged ≥ 40 yr. The prevalence of COPD (FEV1/FVC < 0.7) in subjects ≥ 40 yr of age was 14.1%. Multivariate analysis showed that underweight (odds ratio [OR] 3.07, 95% confidence interval [CI] 1.05-8.98), coronary heart disease (OR, 0.43; 95% CI, 0.20-0.93) and dyslipidemia (OR, 0.61; 95% CI, 0.45-0.82) were significantly associated with COPD, whereas allergic rhinitis, anemia, arthritis, chronic renal failure, depression, diabetes mellitus, hypertension, gastrointestinal ulcer, and osteoporosis were not. Underweight might be more prevalent but coronary heart disease and dyslipidemia are less prevalent in Koreans with than without COPD in population setting.

Quantifying comorbidity in individuals with COPD: a population study

“…This new knowledge emphasises the need to both consider COPD when managing other diseases and address other diseases when managing people with COPD. Our findings are consistent with previous population-based studies demonstrating an association between COPD and a wide range of comorbidities [13,[21][22][23][24][25][26][27][28][29]. For example, GARCIA-RODRIGUEZ et al [23] found an increased risk of lung cancer (relative risk 3.33, 95% CI 2.33-4.75) and heart failure (relative risk 2.94, 95% CI 2.46-3.51), while NG et al [27] found an increased risk of depressive symptoms (OR 1.86, 95% CI 1.25-2.75) among those with COPD compared with those without.…”

Comorbidity between chronic obstructive pulmonary disease and type 2 diabetes: A nation-wide cohort twin study

“…Our results are in line with the findings from the Women's Health Study, in which Song and colleagues found that women who had ever reported COPD had an increased risk of co-morbidity of type 2 diabetes; the multivariate relative risk was 1.38 [16]. In contrast, studies by Joo and colleagues of a Korean population [21] and by Lindberg et al of a Swedish population [20] found no association between COPD and type 2 diabetes. In the latter study restrictive lung function was strongly associated with diabetes compared with both normal and obstructive lung function.…”

The relationship between chronic obstructive pulmonary disease and comorbidities: A cross-sectional study using data from KNHANES 2010–2012

“…Second, we defined comorbidities objectively using laboratory results, such as fasting glucose and HbA1c for DM, and physical findings, such as systolic and diastolic blood pressure, for hypertension. In most previous studies, the definition of comorbid conditions of COPD depended on self-reported questionnaires [8,31,32].…”