Comorbidities, medications and depressive symptoms in patients with restless legs syndrome and migraine

Ferreira, Karen Spadari; Éckeli, Alan Luiz; Dach, Fabíola; Speciali, José Geraldo

doi:10.1590/s0004-282x2013005000007

Cited by 11 publications

(17 citation statements)

References 29 publications

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“…In a recent nationwide, population-based cohort study conducted in Taiwan, we detected an increased risk of RLS in patients with migraine when compared with non-migraineurs, regardless of comorbidities or migraine subtype [ 36 ]. Further, Ferreira et al [ 37 ] observed that RLS prevalence was higher in patients with migraine than in controls in a Brazilian cohort, though they did not analyze whether RLS prevalence differed with respect to presence of auras or headache attack frequency, for which the sample sizes were likely too small to provide sufficient power. More recently, a large population-based study that collected data from approximately 2300 patients has indicated that RLS is more prevalent and more severe in patients with migraine, and is also associated with poorer sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of restless legs syndrome in migraine patients with and without aura: a cross-sectional, case-controlled study

Lin

Lee

et al. 2016

J Headache Pain

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BackgroundAlthough the comorbidity of migraine and restless legs syndrome (RLS) has been well-documented, the association between RLS and migraine frequency has yet to be elucidated. The present study aims to evaluate the prevalence of RLS among individuals who experience low-frequency, high-frequency, or chronic migraine presenting with and without aura.MethodsWe conducted a cross-sectional, case-controlled study involving 505 participants receiving outpatient headache treatment. Standardized questionnaires were administered to collect information on experiences of migraine, RLS, sleep quality, anxiety, depression, and demographics. Participants were categorized into low-frequency (1–8/month), high-frequency (9–14/month), and chronic (≥15/month) headache groups. RLS was diagnosed according to the criteria outlined by the International RLS Study Group (IRLSSG). The Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS) were used to assess sleep quality and identify symptoms of anxiety and depression. Associations between migraine frequency and RLS prevalence were investigated using multivariate linear and logistic regression.ResultsUnivariate analysis revealed an effect of migraine frequency on RLS prevalence (p = 0.026), though this effect did not persist following adjustment for baseline characteristics (p = 0.256). The trend was robust in patients whose migraines presented with auras (p univariate = 0.002; p multivariate = 0.043) but not in those without auras (p univariate and p multivariate > 0.05). Higher anxiety [odds ratio (OR) = 1.18, p = 0.019] and sleep disturbance (OR = 1.17, p = 0.023) scores were associated with higher RLS prevalence.ConclusionsHigher migraine frequency correlates with a higher prevalence of RLS, particularly among patients with auras.

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Section: Discussionmentioning

confidence: 99%

Prevalence of restless legs syndrome in migraine patients with and without aura: a cross-sectional, case-controlled study

Lin

Lee

et al. 2016

J Headache Pain

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“…Most estimates of RLS/WED prevalence among migraine patients is higher than in the general population, reaching 25 % [51][52][53]. Severity and family history for RLS/WED are also higher in migraine then in non-migraine patients [51][52][53][54].…”

Section: Rls/wed and Migrainementioning

confidence: 98%

“…Severity and family history for RLS/WED are also higher in migraine then in non-migraine patients [51][52][53][54]. In two large cross-sectional studies involving, respectively, 31,370 female and 22,926 male participants, any history of migraine was associated with a multivariableadjusted OR of 1.22 and 1.20 [55,56].…”

Section: Rls/wed and Migrainementioning

confidence: 99%

Restless Legs Syndrome and Pain Disorders: What’s in common?

Goulart

Rodrigues

Peres

2014

Curr Pain Headache Rep

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Between 10 % and 30 % of the population report chronic pain. More than half of these also have sleep complaints. From considering these data, it can be inferred there is a significant overlapping between these conditions. Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is characterized by complaints of an "urge to move" frequently associated with dysesthesias. From that perspective, these sensations can also have painful characteristics. By the same token, the presence of comorbid diseases as predicted by a higher prevalence RLS/WED, have many of them with pain as an important complaint. Pain is a multidimensional response involving several levels of expression ranging from somatosensory to emotional. The potential shared mechanisms between RLS/WED and pain may involve sleep deprivation/fragmentation effect, inducing an increase in markers of inflammation and reduction in pain thresholds. These are modulated by several different settings of neurotransmitters with a huge participation of monoaminergic dysfunctional circuits. A thorough comprehension of these mechanisms is of utmost importance for the correct approach and treatment choices.

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“…48 Since some of these comorbidities are also more frequent in migraine, this would be an interesting point for the investigation of the causal relationship between the two diseases. 49 A curious topic is the treatment of RLS and its possible relationship with migraine. The treatment of RLS is indicated for patients with important symptoms that may interfere with sleep and the quality of life.…”

Section: Restless Legs Syndromementioning

confidence: 99%

“…49 Sleep disorders as well as insomnia and sleep deprivation, which may trigger migraine, are more frequent in patients with RLS. Depressive disorder is more frequent in patients with migraine than in patients with RLS.…”

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confidence: 99%

Migraine and restless legs syndrome: current perspectives

Ferreira¹,

Dach²,

Éckeli³

et al. 2015

JPRLS

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Abstract:The relationship between migraine and restless legs syndrome (RLS) has been described in the literature for some years, based on clinical findings and pathophysiological considerations. There are some possible factors relating migraine and RLS. Both are diseases involving the central nervous system, the two diseases seem to share a dopaminergic mechanism, and it is also believed that they may share a genetic origin. At present, doctors who work with these two diseases should be encouraged not to simply investigate the simultaneous presence of both, but should also apply a treatment better adapted to this possibility. Research should be directed at some still unanswered questions for a better understanding of the association between migraine and RLS.

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Comorbidities, medications and depressive symptoms in patients with restless legs syndrome and migraine

Cited by 11 publications

References 29 publications

Prevalence of restless legs syndrome in migraine patients with and without aura: a cross-sectional, case-controlled study

Prevalence of restless legs syndrome in migraine patients with and without aura: a cross-sectional, case-controlled study

Restless Legs Syndrome and Pain Disorders: What’s in common?

Migraine and restless legs syndrome: current perspectives

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