Comorbidities in Patients With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation: A Review of the Literature From the Past Decade

Nellesen, Dave; Chawla, Anita; Oh, Debora L.; Weissman, Taryn; Lavins, Bernard J.; Murray, Christopher W.

doi:10.3810/pgm.2013.03.2640

Cited by 52 publications

(45 citation statements)

References 59 publications

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“…The prevalence of anxiety and depression in DD patients was much higher than the rates in the general population. These findings are consistent with previous literature that has documented a positive association-though not a causal relationship-between certain psychological disorders and DD [37,38]. We found that DD patients also have lower quality of life than the general population.…”

Section: Discussionsupporting

confidence: 83%

Efficacy and Predictors for Biofeedback Therapeutic Outcome in Patients with Dyssynergic Defecation

Yu¹,

Lin²

2017

Gastroenterology

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Section: Discussionsupporting

confidence: 83%

Efficacy and Predictors for Biofeedback Therapeutic Outcome in Patients with Dyssynergic Defecation

Yu¹,

Lin²

2017

Gastroenterology

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“…Patients suffering from comorbid conditions like diabetes, hypothyroidism, hypertension and cardiovascular, neurological, GI and other metabolic disorders frequently experience constipation due to disordered colonic and/or pelvic floor/anorectal function 37 . In the present study, higher proportion of FC patients had a history of hypertension (16%) and diabetes (10.2%); resulting in higher utilization of antihypertensive and antidiabetic medications, further leading to lower frequency of bowel movements.…”

Section: Discussionmentioning

confidence: 99%

“…21,39 In another study, dyspepsia and diabetes were reported as the most common comorbidities in patients with IBS-C and FC, respectively. 37 In addition, 7.15% patients of FC were on antidepressants for management of stress/ anxiety/ depression. Literature review reports that anxiety/depression is the independent risk factors for constipation.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of functional constipation and constipation-predominant irritable bowel syndrome in Indian patients with constipation

Rooprai

Bhat

Sainani³

et al. 2017

Int J Basic Clin Pharmacol

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Background: Evaluate prevalence of functional constipation (FC) and irritable bowel syndrome-constipation (IBS-C) in Indian constipated patients and assess their demographic/socio-economic/clinical characteristics.Methods: Patients (≥18 years) who visited their general physician with symptoms of constipation (Rome III criteria for FC or IBS-C as per physician assessment) and willing to participate were enrolled in this prospective, clinical-epidemiological study. Demographic, socioeconomic status, lifestyle and dietary habits, comorbid conditions, treatment history, concomitant medications, stool form (Bristol stool form scale), severity of constipation (constipation scoring system [CSS]), constipation-related symptoms (patient assessment of constipation symptoms [PAC-SYM]) and quality of life (patient assessment of constipation-quality of life questionnaire [PAC-QoL]) were recorded.Results: Out of 925 constipated patients, 75.6% were diagnosed with FC against 24.4% with IBS-C (P < 0.0001). Patients of both subtypes had high average scores of PAC-SYM (FC: 27.1 ± 6; IBS-C: 30.1 ± 4.9) and CSS (FC: 8.4 ± 3.1; IBS-C: 11.2 ± 3), leading to high PAC-QoL score (FC: 38.1 ± 16.8; IBS-C: 42.2 ± 13.6). Hypertension (16%) and diabetes (10%) in patients with FC while acid peptic disorders (21.7%) amongst IBS-C patients were the most common comorbid conditions observed. Laxatives were the most common medication used; osmotic (32.6% versus 40.7%) and bulk laxatives (22.8% versus 37.4%) were the commonest laxatives. However, about 1/5th patients of FC were using home remedies.Conclusions: There was a higher prevalence of FC over IBS-C in Indian constipated patients; both subtypes had high frequency and severity of constipation-related symptoms and poor QoL.

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“…In a systematic review which analyzed 35 studies about comorbid conditions in IBS-C and chronic idiopathic constipation, FD and depression were reported as the most common comorbid diseases in patients with IBS-C, whereas FD, DM, and depression were the most commonly overlapping diseases in patients with chronic idiopathic constipation. 31 In another web-based, crosssectional study conducted in the United States, the impact of overlapping FD, GERD, IBS-C, and FC on symptom burden and consulting behavior was assessed. 32 Of the 2641 responders, 328 and 552 persons met the Rome III criteria for IBS-C or FC, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…It is not difficult to predict that the quality of life will be lower with more severe symptoms in the overlapping groups, and there are several reports on this. 3,5,6,31 In this study, we assessed both constipation-associated QOL and general health-related QOL with PAC-QOL and EQ-5D-3L questionnaires, respectively. PAC-QOL questionnaire contains 28 items assigned to 4 domains: worries and concerns (11 items), physical discomfort (4 items), psychosocial discomfort (8 items), and satisfaction (5 items).…”

Section: Discussionmentioning

confidence: 99%

Nationwide Multicenter Study for Overlaps of Common Functional Gastrointestinal Disorders in Korean Patients With Constipation

Park

Jee

Lee

et al. 2017

J Neurogastroenterol Motil

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Background/AimsIn spite of increased concerns about the overlaps among the various functional gastrointestinal disorders (FGIDs), studies for the overlap between constipation and other common FGIDs are rare. Therefore, we investigated the patterns of overlaps between constipation and other common FGIDs. Methods This study was designed as a prospective nationwide multi-center questionnaire study using Rome III questionnaires for functional dyspepsia (FD), irritable bowel syndrome (IBS), and functional constipation (FC), as well as various questionnaires about patients' information, degree of symptoms, and quality of life. For the evaluation of gastroesophageal reflux disease (GERD), GERD-Q was used. Results From 19 centers, 759 patients with constipation were enrolled. The proportions of FC and IBS subtypes of constipation (IBS-C) were 59.4% and 40.6%, respectively. Among them, 492 (64.8%) showed no overlap. One hundred and thirty-six patients (17.9%) presented overlapping GERD, and 80 patients (10.5%) presented overlapping FD. Fifty one (6.7%) of patients were overlapped by both GERD and FD. Coincidental herniated nucleus pulposus (HNP) (P = 0.026) or pulmonary diseases (P = 0.034), reduced fiber intake (P = 0.013), and laxative use (P < 0.001) independently affected the rate of overlaps. These overlapping conditions negatively affected the constipation-associated quality of life, general quality of life, and degree of constipation. ConclusionsThe overlap of GERD or FD was common in patients with constipation. Coincidental HNP or pulmonary diseases, reduced fiber intake, and laxatives use were found to be independent associated factors for overlapping common FGIDs in Korean patients with constipation.

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Comorbidities in Patients With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation: A Review of the Literature From the Past Decade

Abstract: Patients with IBS-C or CIC frequently experience a wide range of comorbidities that contribute to their disease burden. Thus, we believe that medical professionals should consider common comorbidities when diagnosing and treating patients with IBS-C or CIC.

Cited by 52 publications

References 59 publications

Efficacy and Predictors for Biofeedback Therapeutic Outcome in Patients with Dyssynergic Defecation

Efficacy and Predictors for Biofeedback Therapeutic Outcome in Patients with Dyssynergic Defecation

Prevalence of functional constipation and constipation-predominant irritable bowel syndrome in Indian patients with constipation

Nationwide Multicenter Study for Overlaps of Common Functional Gastrointestinal Disorders in Korean Patients With Constipation

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