Comorbidities in Patients With End-Stage Knee OA: Prevalence and Effect on Physical Function

Kim, Won Bin; Kim, Bo Ryun; Kim, Sang Rim; Han, Eun Young; Nam, Kwang Woo; Lee, So Young; Ji, Suh Min; Kim, Jong Hyun

doi:10.1016/j.apmr.2019.04.005

Cited by 11 publications

(18 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the strategies which may have helped reduced TFJ loading during early stance is reducing the speed of performing stair ascent. Those with both mild 6,21,22 and severe 23 OA have reportedly performed stair ascent slower than their aged‐matched controls. Indeed, slowing down stair ambulation would allow more time during the stance phase, where the initial loading during early stance can be done more gradually.…”

Section: Discussionmentioning

confidence: 99%

The influence of pain on tibiofemoral joint contact force and muscle forces in knee osteoarthritis patients during stair ascent

Price

Gissane

Cleather

2020

Engineering Reports

View full text Add to dashboard Cite

This study investigated the tibiofemoral joint (TFJ) forces and supporting muscle forces displayed by knee osteoarthritis (OA) patients during stair ascent, and if these forces were influenced by the presence of pain. Fifteen knee OA patients partitioned into two groups based on pain experienced during stair ascent trails using a Visual Analogue Scale (VAS) (OA-pain = 10; OA-no pain = 5) and 14 healthy aged-matched controls took part in this study. Kinematic and kinetic data were collected during three stair ascent trials, which provided the inputs for the musculoskeletal model FreeBody. TFJ contact forces and muscles forces were predicted by the model at early, mid-and late stance. These variables were compared between groups using a one-way analysis of variance. The results show the OA-pain (P < .05; d = 2.4) and OA-no pain (P < .05; d = 1.1) groups displayed reduced medial TFJ contact forces and altered muscle forces in comparison to healthy controls during early stance. This suggests pain and the anticipation of pain results in knee OA patients deliberately offloading the front limb during stair ascent, which alters supporting muscle forces. This study provides valuable information on knee OA mechanics during stair ascent for clinicians developing rehabilitation programs. K E Y W O R D S muscle forces, musculoskeletal model, osteoarthritis, stair ascent, tibiofemoral joint forces 1 INTRODUCTION Stair ascent is a challenging everyday activity for those who suffer with knee osteoarthritis (OA). Many studies have reported stair ascent being one of the main activities which elicits knee pain for those with knee OA, 1,2 greatly affecting quality of life. 3 The increased susceptibility of knee pain during stair ascent likely comes from weight-bearing at higher knee flexion angles. 4 Because of this, knee OA patients have been reported to compensate while walking upstairs to offload the OA knee as a strategy to avoid pain. 5 Asay et al 4 reported that during stair ascent those with knee OA increased trunk flexion angle during the weight-acceptance phase of stance to reduce the quadriceps moment in comparison to healthy controls. Further, Meireles et al 6 found that, in comparison to healthy controls, knee OA patients altered their stair ascent This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: Discussionmentioning

confidence: 99%

The influence of pain on tibiofemoral joint contact force and muscle forces in knee osteoarthritis patients during stair ascent

Price

Gissane

Cleather

2020

Engineering Reports

View full text Add to dashboard Cite

show abstract

“…The mean BMI and prevalence of obesity were 26.1 ± 3.2 kg/m 2 and 62.3% (48/77) in males and 26.6 ± 3.2 kg/m 2 and 67.8% (329/485) in females. The mean appendicular muscle mass/height 2 and low muscle mass prevalence were 7.58 ± 0.74 and 19.5% (15/77) in males and 6.54 ± 2.96 and 5.2% (25/485) in females. Comparing males and females, the obesity rate was 5.5% higher in females and the low muscle mass rate was 14.3% higher in males.…”

Section: Resultsmentioning

confidence: 92%

“…In patients with knee OA, various comorbidities are present, including poor physical function, pain, and reduced quality of life (QOL). 1 , 2 …”

Section: Introductionmentioning

confidence: 99%

“…In patients with knee OA, various comorbidities are present, including poor physical function, pain, and reduced quality of life (QOL). 1,2 There are several risk factors for knee OA, including obesity. 3,4 Obesity is associated with the development of knee OA, 5 and after total knee arthroplasty (TKA) surgery, deep prosthetic infections and wound complication are more prevalent in obese patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Associations Between Obesity With Low Muscle Mass and Physical Function in Patients With End-Stage Knee Osteoarthritis

Kim

Lee

Kim

et al. 2021

Geriatr Orthop Surg Rehabil

Self Cite

View full text Add to dashboard Cite

Objective: To investigate the prevalence of obesity with low muscle mass and its impact on physical function, quality of life (QOL) and pain in patients with end-stage knee osteoarthritis over 65 years old. Methods: In this cross-sectional study, we assessed a total of 562 patients. After separating the group into males and females, we divided patients into 4 further groups: normal BMI with normal muscle mass, obesity with normal muscle mass, normal BMI with low muscle mass and obesity with low muscle mass. All patients completed stair climbing test (SCT), 6-minute walk test, timed up and go test (TUG), instrumental gait analysis, Western Ontario McMaster Universities Osteoarthritis Index, VAS, and EuroQOL 5 dimensions questionnaire. Results: Obesity with low muscle mass was diagnosed in 6 males subjects (7.8%) and 9 female subjects (1.9%). Patients with obesity and low muscle mass performed the SCT-ascent and descent significantly slower than other body composition groups in both males and females. TUG in males and gait speed in females were also significantly slower in the obesity with low muscle mass group. Stepwise multiple linear regression analysis revealed that in males, obesity with low muscle mass was significantly predictive of SCT ascent (β = 0.409, p < 0.001), SCT-descent (β = 0.405, p < 0.001), and TUG (β = 0.283, p = 0.009), and in females, obesity with low muscle mass was significantly predictive of SCT-ascent (β = 0.231, p < 0.001), SCT-descent (β = 0.183, p < 0.001), and gait speed (β=-0.129, p = 0.004). Conclusions: This study confirms that the combination of obesity and low muscle mass is associated with impaired physical function in patients with end-stage knee osteoarthritis.

show abstract

“…7,8 Additionally, knee OA is often associated with comorbidities, including obesity, depression and anxiety. 9,10 Up to 50% of knee OA patients also have generalized OA (3 or more joints) 11 which is associated with incrementally higher rates of comorbidities. 12 Many of these comorbid conditions such as diabetes and depressive symptoms have also been shown to impact pain, functionality, and quality of life, [13][14][15] all of which further increase the clinical and economic burden of knee OA.…”

Section: Introductionmentioning

confidence: 99%

Real-World Health Care Resource Utilization and Costs Among US Patients with Knee Osteoarthritis Compared with Controls

Bedenbaugh¹,

Bonafede²,

Marchlewicz³

et al. 2021

CEOR

View full text Add to dashboard Cite

Purpose: To determine the prevalence, healthcare resource utilization and costs (HCRU&C) of knee osteoarthritis (OA) patients versus controls. Patients and Methods: Retrospective, matched-cohort administrative claims analysis using IBM MarketScan databases (2011)(2012)(2013)(2014)(2015)(2016)(2017). Newly diagnosed, adult (18+ yrs) knee OA patients identified by ICD9/10 code were matched 1:1 to controls by age, sex, payer, and geography; alpha level set to 0.05. Prevalence was estimated for 2017. All-cause and knee OA-related HCRU&C reported per-patient-per-year (PPPY) over follow-up period up to 4 years. Results: Overall 2017 knee OA prevalence was 4% (615,514 knee OA/15.4M adults). A total of 510,605 patients meeting inclusion criteria were matched 1:1 with controls. The knee OA cohort had mean age 60 years and was 58% female. Versus controls, knee OA patients had significantly more PPPY outpatient (84.5 versus 45.0) and pharmacy (29.8 versus 19.8

show abstract

Comorbidities in Patients With End-Stage Knee OA: Prevalence and Effect on Physical Function

Cited by 11 publications

References 49 publications

The influence of pain on tibiofemoral joint contact force and muscle forces in knee osteoarthritis patients during stair ascent

The influence of pain on tibiofemoral joint contact force and muscle forces in knee osteoarthritis patients during stair ascent

Associations Between Obesity With Low Muscle Mass and Physical Function in Patients With End-Stage Knee Osteoarthritis

Real-World Health Care Resource Utilization and Costs Among US Patients with Knee Osteoarthritis Compared with Controls

Contact Info

Product

Resources

About