Comorbidities in combined retinal artery and vein occlusions

Schmidt, Dieter

doi:10.1186/2047-783x-18-27

Cited by 35 publications

(36 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The retinal arteries were ultimately obliterated which clinically seen as white cord. FFA revealing delayed arterial filling time which further supports the diagnosis of combined CRVO-CRAO entity [4].…”

Section: Discussionsupporting

confidence: 59%

Central Retinal Artery Occlusion Following Central Retinal Vein Occlusion- A Case Report

Noh¹,

Fang²,

Din³

2015

J Diabetes Metab

View full text Add to dashboard Cite

A 73-year-old gentleman with diabetes mellitus was found to have impending central retinal vein occlusion (CRVO), on routine eye checkup. Despite initiation of anti-platelet agent, he developed ischaemic CRVO two months later, with severe macula oedema. His systemic investigations showed good diabetic control, no blood dyscrasia/ hypercoagulable state, normal lipid profile and inflammatory markers. Echocardiogram was normal. A month later, arteriolar attenuation was noted with rubeosis irides, and fluorescein angiogram study confirmed central retinal artery occlusion (CRAO). After ruling out the systemic risk factors, we postulate two possible anatomical related patho-mechanism of CRAO following CRVO: 1, CRVO converts the retinal circulation into a closed loop, results in complete hemodynamic block of the retinal circulation, and hence secondary CRAO; 2, swollen retinal nerve fibres at the optic nerve head secondary to CRVO cause compression to the retinal artery at the level of the lamina cribrosa, this compression is further aggravated by the increased in intraocular pressure (IOP), and hence secondary CRAO.

show abstract

Section: Discussionsupporting

confidence: 59%

Central Retinal Artery Occlusion Following Central Retinal Vein Occlusion- A Case Report

Noh¹,

Fang²,

Din³

2015

J Diabetes Metab

View full text Add to dashboard Cite

show abstract

“…In addition, in the clinical situation, CRVO and central retinal artery occlusion are sometimes observed together in the same patient. 43 We therefore think that our model reproduces key aspects of clinical CRVO.…”

Section: Discussionmentioning

confidence: 77%

Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin–Receptor Activity–Modifying Protein 2 System

Hirabayashi

Tanaka

Imai

et al. 2019

The American Journal of Pathology

View full text Add to dashboard Cite

Central retinal vein occlusion (CRVO) is an intractable disease that causes visual acuity loss with retinal ischemia, hemorrhage, and edema. In this study, we developed an experimental CRVO model in mice and evaluated the therapeutic potential of the pleiotropic peptide adrenomedullin (ADM) and its receptor activityemodifying protein 2 (RAMP2). The CRVO model, which had phenotypes resembling those seen in the clinic, was produced by combining i.p. injection of Rose bengal, a photoactivator dye enhancing thrombus formation, with laser photocoagulation. Retinal vascular area, analyzed using fluorescein angiography and fluorescein isothiocyanateeperfused retinal flat mounts, was decreased after induction of CRVO but gradually recovered from day 1 to 7. Measurements of retinal thickness using optical coherence tomography and histology revealed prominent edema early after CRVO, followed by gradual atrophy. Reperfusion after CRVO was diminished in Adm and Ramp2 knockout (KO) mice but was increased by exogenous ADM administration. CRVO also increased expression of a coagulation factor, oxidative stress markers, and a leukocyte adhesion molecule in both wild-type and Adm KO mice, and the effect was more pronounced in Adm KO mice. Using retinal capillary endothelial cells, ADM was found to directly suppress retinal endothelial injury. The retinoprotective effects of the Adm-Ramp2 system make it a novel therapeutic target for the treatment of CRVO.

show abstract

“…Atherosclerosis, advanced age, hypertension, hyperlipidemia, diabetes, smoking and positive family history are well known the most important risk factors. 11,12 Thrombophilia, high blood viscosity, systemic vasculitis, or autoimmune diseases are other systemic risk factors. [12][13][14][15] Our patient has also several risk factors such as hypertension, atherosclerosis, smoking, and positive family history despite of his relatively young age.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2023

NCOAJ

View full text Add to dashboard Cite

Ophthalmic artery provides blood supply of the eye that is a branch of internal carotid artery (ICA). ICA occlusive disease (ICAOD) causes reduction in perfusion pressure of the ophthalmic artery and its branches. So, unilateral blurred low vision can be seen due to chronic progressive ocular ischemia. We presented a subject with low vision and retinal arterial narrowing, arteriovenous nipping, retinal hemorrhages, roth spots, and loss of foveal light reflex were present in the fundus. Macular edema were seen with optical coherence tomography (OCT) and delay in arterial filling, capillary dropout, and foveal late-phase leakage were seen with fundus fluorescein angiography (FFA).Our patient has several risk factors such as hypertension, atherosclerosis, smoking, and positive family history despite of his relatively young age. In this case report, we aimed to take attention the possibility of unilateral chronic low vision due to ICAOD in a young subject.

show abstract

Comorbidities in combined retinal artery and vein occlusions

Cited by 35 publications

References 46 publications

Central Retinal Artery Occlusion Following Central Retinal Vein Occlusion- A Case Report

Central Retinal Artery Occlusion Following Central Retinal Vein Occlusion- A Case Report

Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin–Receptor Activity–Modifying Protein 2 System

Untitled

Contact Info

Product

Resources

About