Comorbidities and medical complexities of mobility device users: a retrospective study

LaBerge, Nicole B.; Detterbeck, Ashley; Nooijen, Carla F J

doi:10.1080/17483107.2021.1969453

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…Another highlight of this study was that sepsis predominantly developed from UTIs in the NMOSD-satralizumab cohort. It has been reported that motor deficits increase the risk of infections, and among patients with gait impairments, they are more susceptible to UTIs than other types of infections ( 5 ). Since PMDA did not supply data based on the Expanded Disability Status Scale (EDSS), we could not include EDSS data.…”

Section: Discussionmentioning

confidence: 99%

Urosepsis Risk in Neuromyelitis Optica Spectrum Disorder Patients Administered Satralizumab

Fujita

Aratake

Nakata³

et al. 2023

Intern. Med.

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ObjectivesThe interleukin-6 (IL-6) inhibitor satralizumab is an established treatment for neuromyelitis optica spectrum disorder (NMOSD). Although IL-6 inhibitors are generally well-tolerated, serious infections, including sepsis, can occur. In this study, we compared the sepsis characteristics in NMOSD patients administered satralizumab (NMOSD-satralizumab) to those in rheumatoid arthritis patients administered tocilizumab (RA-tocilizumab), another IL-6 inhibitor. Methods We examined adverse event reports from the Japanese Pharmaceuticals and Medical Devices Agency regarding NMOSD-satralizumab from August 2020 to March 2022 and RA-tocilizumab from April 2008 to November 2019 (term 1) and to March 2022 (term 2). ResultsWe identified 6 sepsis cases in NMOSD-satralizumab, of which 5 (83%) developed from urinary tract infections (UTIs). Although data were unavailable for two patients, three cases had urologic complications in addition to recognized risk factors for serious infections, such as an older age, corticosteroid use, obesity, diabetes mellitus and motor disability. Urosepsis was relatively infrequent in RA-tocilizumab (term 1: 24.2%, term 2: 20.1%). Discussion Safe satralizumab use requires risk factor assessment to minimize the incidence of severe infections. Management of UTIs is also recommended.

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Section: Discussionmentioning

confidence: 99%