Comorbidities and diabetic complications in patients with necrobiosis lipoidica

Severson, Kevin J.; Patel, Meera H.; Brumfiel, Caitlin M.; Breen, Ilana; Butterfield, Richard J.; Nelson, Sara; Sekulic, Aleksander; Pittelkow, Mark R.; Mangold, Aaron R.

doi:10.1016/j.jaad.2021.03.026

Cited by 4 publications

(1 citation statement)

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“…Necrobiosis lipoidica (NL), which can be idiopathic or related to underlying diabetes mellitus (DM), is one such disorder. Prompt and accurate histopathologic diagnosis can aid the clinician to perform the appropriate systemic work‐up and pursue appropriate therapy and monitoring 1,2 …”

Section: Introductionmentioning

confidence: 99%

Histopathologic features of necrobiosis lipoidica

et al. 2022

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Background Necrobiosis lipoidica (NL) is an uncommon granulomatous dermatosis that can occur in patients with or without associated diabetes mellitus (DM). Prior studies have attempted to determine distinctive histopathologic features of NL in patients with and without DM. Methods A retrospective review of 97 patients with NL was performed to determine the similar and distinctive histopathologic features in patients with DM and without DM. Results Of the 97 patients, 32% (n = 31) had DM. Epidermal acanthosis was seen more commonly in diabetics than nondiabetics (32.3% vs. 12.1%; p = 0.017). Naked (sarcoidal/tuberculoid) granulomas were more frequently observed in nondiabetics than diabetics (22.7% vs. 3.2%; p = 0.016). Eosinophils were more common in nondiabetics than diabetics (38.5% vs. 9.7%; p = 0.004), while neutrophilic infiltration was more common in diabetics than nondiabetics (45.2% vs. 17.5%; p = 0.004). Conclusions This study corroborates well‐documented histopathologic features of NL and shows distinctive histopathologic features of NL among patients with DM‐I, DM‐II, and without DM. These results support the hypothesis that there are different underlying drivers of NL between diabetics and nondiabetics.

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Section: Introductionmentioning

confidence: 99%