Comorbidities and complications of polycystic ovary syndrome: An overview of systematic reviews

Gilbert, Emily W.; Tay, Chau Thien; Hiam, Danielle; Teede, Helena; Moran, Lisa J.

doi:10.1111/cen.13828

Cited by 124 publications

(89 citation statements)

References 73 publications

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“…PCOS has metabolic implications including insulin resistance, dyslipidaemia and abnormal glucose metabolism in the form of IGT or type 2 diabetes mellitus. 37 Moreover, women with PCOS also has a tendency for excess weight gain which exacerbates these symptoms. Cardiovascular risk factors such as chronic inflammation, oxidative stress and impaired fibrinolysis are increased and there is evidence that cardiovascular disease (CVD) has a higher prevalence in these women.…”

Section: Comorbidities and Long Term Health Issuesmentioning

confidence: 99%

“…55 PCOS also negatively impacts health-related quality of life (HRQoL) and may limit a woman's ability to optimize healthy lifestyle. 37,40…”

Section: Comorbidities and Long Term Health Issuesmentioning

confidence: 99%

“…51 The key role of excess weight in worsening reproductive, metabolic and psychological outcomes in PCOS has also been recognized in all the researches and analyses. 37 The international guideline in PCOS recommends that BMI be assessed in all women with PCOS and that prevention of excess weight gain is vital and weight loss is recommended as the first-line treatment for overweight or obese women. 17,52 Metabolic Syndrome (MetS)…”

Section: Obesitymentioning

confidence: 99%

“…In a review by Gilbert et al 37 existing systematic reviews and meta-analyses were summarized evaluating comorbidities and complications of PCOS. They went through a large number of reviews (n = 23) that included 575 studies and over a million participants (1,090,072).…”

Section: Cardiovascular Diseasementioning

confidence: 99%

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Polycystic Ovary Syndrome: A Brief Review with Recent Updates

2020

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Polycystic ovary syndrome (PCOS) is a chronic, complex and the most common endocrine disorder observed in women of reproductive age. This syndrome is heterogeneous by nature and is characterized by a combination of signs and symptoms of androgen excess and ovarian dysfunction. It is a significant public health issue. PCOS is associated with many comorbidities and also has a number of long-term metabolic and other consequences. The prevalence is quite high and is increasing day by day. It is a syndrome to be prevented by awakening awareness both in health workers and patients. There are many areas of controversies starting from its diagnosis, pathogenesis, consequences and treatment modalities. This review is an attempt to summarize the evolution of the diagnosis and current management guidelines and also to look into the future approaches. An extensive search was made through the Cochrane database, available systematic reviews and meta-analyses and recent international guidelines for providing an updated scientific overview of PCOS. Delta Med Col J. Jul 2019 7(2): 84-99

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Section: Comorbidities and Long Term Health Issuesmentioning

confidence: 99%

“…55 PCOS also negatively impacts health-related quality of life (HRQoL) and may limit a woman's ability to optimize healthy lifestyle. 37,40…”

Section: Comorbidities and Long Term Health Issuesmentioning

confidence: 99%

Section: Obesitymentioning

confidence: 99%

Section: Cardiovascular Diseasementioning

confidence: 99%

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Polycystic Ovary Syndrome: A Brief Review with Recent Updates

2020

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“…Polycystic ovary syndrome (PCOS) is a complex endocrinopathy characterized by oligomenorrhoea, hyperandrogenism and polycystic ovary morphology on ultrasound that affects 8-13% of young women [32,33]. It is associated with a wide range of reproductive (menstrual irregularity, anovulation), endocrine (impaired glucose tolerance, type 2 diabetes) and metabolic (metabolic syndrome, fatty liver, increased cardiovascular risk factors) complications [34][35][36][37][38]. Mental health disorders such as depression, anxiety and eating disorders are prevalent in women with PCOS and psychological screening is advocated by the latest International evidence-based guideline for the assessment and management of PCOS [39,40].…”

Section: Introductionmentioning

confidence: 99%

Perinatal Mental Health in Women with Polycystic Ovary Syndrome: A Cross-Sectional Analysis of an Australian Population-Based Cohort

Tay

Teede

Boyle

et al. 2019

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Women with polycystic ovary syndrome (PCOS) have many risk factors associated with perinatal mental disorders, but research in this area is scarce. This study aims to compare the prevalence of common perinatal mental disorders in women with and without PCOS, and examine the relationship between PCOS and common perinatal mental disorders. We performed a cross-sectional study on self-reported data of 5239 women born between 1973 to 1978 in the Australian Longitudinal Study on Women's Health. Compared with women not reporting PCOS, women reporting PCOS had higher prevalence of antenatal depression (8.9% vs. 4.4%, p < 0.001), antenatal anxiety (11.7% vs. 5.6%, p < 0.001), postnatal depression (26.8% vs. 18.6%, p < 0.001) and postnatal anxiety (18.4% vs. 12.0%, p < 0.001). PCOS was positively associated with antenatal depression and/or anxiety (adjusted odds ratio 1.8, 95% confidence interval 1.2-2.6) but not postnatal depression and/or anxiety after controlling for sociodemographic and lifestyle factors, reproductive history, obstetric complications and pre-existing depression and anxiety. General perinatal guidelines currently do not recognize PCOS as a risk factor and the international evidence based PCOS guideline noted inadequate evidence in this area. This paper addresses the gap in literature and highlights the need to screen for common perinatal mental disorders in women with PCOS.

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