Background: Coronavirus disease mortality is high in people with chronic kidney disease. Method: we present the characteristics and factors associated with mortality of patients hospitalized for Covid-19 and with chronic kidney disease in a descriptive and analytical cross-sectional study of CKD patients admitted to the Lomé Commune Regional Hospital Center (CHR-LC) from March 2020 to August 2021. Results: A total of 127 patients met our inclusion criteria. We found a mortality rate of 48.8% in Lomé (Togo). Factors associated with this mortality in our study were severity of Covid-19 (p < 0.0001), length of hospital stay (p < 0.0001), pulse oxygen saturation (p < 0.0014), GFR stage (p = 0.0003), existence of hyperglycemia (p = 0.0036) and use of corticosteroids (p = 0.0336). Conclusion: Mortality is very high in CKD patients with Covid-19.