Comorbid psychopathy is not associated with increased D2 dopamine receptor TaqI A or B gene marker frequencies in incarcerated substance abusers

Smith, Stevens S.; Newman, Joseph P.; Evans, Alida M.; Pickens, Roy W.; Wydeven, Jeff; Uhl, George R.; Newlin, David B.

doi:10.1016/0006-3223(93)90028-c

Cited by 14 publications

(8 citation statements)

References 22 publications

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“…Carriers of the A1-allele showed more pronounced core features and higher total psychopathy scores but did not differ with respect to antisocial lifestyle scores. In contrast, Smith et al (1993) failed to find a relationship between the TaqIA-ANKK1 polymorphism and psychopathy as assessed through the PCL-R in a sample of 80 incarcerated male criminals. All three studies used men with alcohol dependence but Smith compared male criminals that varied in psychopathy scores whereas Ponce and Hoenicka compared psychopathic delinquents and alcoholics with healthy controls, indicating that the participants in these latter samples were more varied in their psychopathy scores.…”

Section: Da Receptor Configuration (D2-receptors)mentioning

confidence: 74%

“…Four different studies have tested the relationship between the TaqIA-ANKK1 polymorphism and psychopathy directly (Smith et al, 1993;Hoenicka et al, 2007;Ponce et al, 2008;Wu and Barnes, 2013). Two of these studies found significant associations between the A1-allele and psychopathy scores (Hoenicka et al, 2007;Ponce et al, 2008).…”

Section: Da Receptor Configuration (D2-receptors)mentioning

confidence: 97%

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Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Yildirim

Derksen

2015

Psychiatry Research

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Section: Da Receptor Configuration (D2-receptors)mentioning

confidence: 74%

Section: Da Receptor Configuration (D2-receptors)mentioning

confidence: 97%

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Yildirim

Derksen

2015

Psychiatry Research

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“…For example, a positive association has been reported between substance dependence/polysubstance abuse (with or without alcohol) and the TaqI A1 and B1 alleles in European American (EA) [O'Hara et al, 1993;Smith et al, 1993;Smith et al, 1992] but not African American (AA) [Berrettini and Persico, 1996;O'Hara et al, 1993] subjects. Comings et al [1994] reported an association between the DRD2 TaqI A1 allele and abuse/dependence on both drugs and alcohol, but not with alcohol abuse/ dependence in the absence of drug dependence.…”

Section: Introductionmentioning

confidence: 96%

Family-Based study of DRD2 alleles in alcohol and drug dependence

2000

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Numerous case-control studies have addressed the hypothesis that variant alleles of the dopamine D2 receptor gene (DRD2) increase the liability for alcohol and/or drug dependence, and both positive and negative results have been reported. Because population frequencies of these alleles vary considerably, the conflicting results could be due to population stratification bias. Using the transmission disequilibrium test, the present study examined linkage disequilibrium of alcohol and drug (opioid and/or cocaine) dependence with three DRD2 polymorphic systems: (a) TaqI A, (b) TaqI D, and (c) the functional -141CIns/Del promoter systems. DNA samples were collected from small nuclear families (SNFs), where one or more offspring met DSM-III-R or DSM-IV criteria for alcohol and/or drug dependence. Because positive association between DRD2 alleles and alcohol and/or drug dependence has been reported only in populations of European ancestry, we limited the present study to European Americans (EAs). No evidence for linkage disequilibrium was found for any of the polymorphic systems when examined in relation to any substance dependence, alcohol dependence (with or without drug dependence), or drug dependence (with or without alcohol dependence). These results are consistent with those from a recent family-based study of alcohol dependence. Together, these studies suggest that the conflicting findings from case-control studies of the association between alleles of DRD2 and substance dependence may be attributable to population stratification in some samples.

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“…Noble et al (1991) described a decrease in the number of dopamine Dz-receptors in striatal tissue from individuals with identified genotypes. Nor did Smith et al (1993) find any association between comorbid psychopathy and DRD2 TaqI A genotype in substance abusers. Nor did Smith et al (1993) find any association between comorbid psychopathy and DRD2 TaqI A genotype in substance abusers.…”

Section: Discussionmentioning

confidence: 76%

“…The association of alcoholism with the dopamine D2-receptor (DRD2) TaqI A1 allele defined by the TaqI A restriction fragment length polymorphism (RFLP) adjacent to the DRD2 gene has over the past 3 years been studied by several investigators in USA (Blum et al 1990;Bolos et al 1990;Blum et al 1991;Comings et al 1991;Gelernter et al 1991;Parsian et al 1991;Cook et al 1992;Turner et al 1992;Blum et al 1993;O'Hara et al 1993;Smith et al 1993), Finland (Goldman et al 1992), France (Amad6o et al 1993) and Japan (Arinami et al 1993). The underlying concepts are the proposed genetic contribution to the susceptibility of alcoholism (Devor and T. Geijer (g~) 9 J. Neiman 9 U. Rydberg 9 A. Gyllander E. J6nsson.…”

Section: Introductionmentioning

confidence: 99%

Dopamine D2-receptor gene polymorphisms in scandinavian chronic alcoholics

Geijer

Neiman

Rydberg

et al. 1994

Eur Arch Psychiatry Clin Nuerosci

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Alterations in the dopamine system have been hypothesized as a predisposing factor in alcoholism. The presence of the TaqI A1 and B1 alleles adjacent to the dopamine D 2-receptor gene (DRD2) was studied in Scandinavian alcoholic inpatients (n = 74), alcoholics autopsied at a forensic clinic (n = 19) and controls (n = 81). There were no significant differences between controls and the alcoholics, but a tendency of increased DRD2 TaqI A1 or B1 allele frequencies in alcoholic groups selected for severity (i.e. severity according to DSM-III-R criteria, early onset or severe medical complications due to alcohol abuse) and decreased frequencies in the corresponding less severe alcoholic group. The present study does not yield evidence for the hypothesis of an association between the DRD2 TaqI A1 or B1 alleles and alcoholism.

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Comorbid psychopathy is not associated with increased D2 dopamine receptor TaqI A or B gene marker frequencies in incarcerated substance abusers

Cited by 14 publications

References 22 publications

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Family-Based study of DRD2 alleles in alcohol and drug dependence

Dopamine D2-receptor gene polymorphisms in scandinavian chronic alcoholics

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