Comorbid obsessive-compulsive disorder and bipolar disorder in a highly endogamous population: which came first?

Bener, Abdülbari; Dafeeah, Elnour E.; Abdulla, Majid Al; Abou‐Saleh, Mohammed T.; Ventriglio, Antonio

doi:10.1080/17542863.2016.1228686

Cited by 3 publications

(8 citation statements)

References 25 publications

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“…The screening of titles and abstracts identified 94 potentially eligible studies. After a full-text revision, 43 studies, based on 38 independent samples, met the eligibility criteria and were included in the meta-analysis (Aksoy et al, 2010; Angst et al, 2013; Ateşci et al, 2010; Bener et al, 2016; Bennett et al, 2019; Berkol et al, 2014; Bernardi et al, 2010; Biederman et al, 2008; Di Nicola et al, 2014; Ghaffary et al, 2013; Gomes et al, 2019; Grigoroiu-Serbanescu et al, 2020; Harmanci et al, 2016; Hegarty et al, 2012; Henin et al, 2007; Jhanda et al, 2018; Karaahmet et al, 2013; Karanti et al, 2020; Koc and Kesebir, 2014; Lan et al, 2015; Makris et al, 2012; Martz et al, 2021; McIntyre et al, 2010; Merikangas et al, 2011; Nierenberg et al, 2005; Oğuz et al, 2014; Pattanshetti et al, 2016; Perroud et al, 2014; Perugi et al, 2013; Pinna et al, 2019; Prunas et al, 2019; Richard-Lepouriel et al, 2019; Rydén et al, 2009a, 2009b; Sachs et al, 2000; Salarvan et al, 2019; Sentissi et al, 2008; Tamam et al, 2008; Torres et al, 2018; Torres et al, 2015; Townsend et al, 2013; Tüysüzoğlu et al, 2011; Walsh et al, 2020). Full search strategy, search result and screening results are described in Supplement 1.…”

Section: Resultsmentioning

confidence: 99%

Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis

Bartoli

Callovini

Cavaleri

et al. 2022

Aust N Z J Psychiatry

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Objective: Attention deficit hyperactivity disorder is a frequent comorbid condition in adults with bipolar disorder. We performed a meta-analysis aimed at assessing sociodemographic and clinical correlates of attention deficit hyperactivity disorder in bipolar disorder. Method: We searched main electronic databases up to June 2021. Random-effects meta-analyses, with relevant meta-regression and quality-based sensitivity analyses, were carried out to estimate the association between attention deficit hyperactivity disorder and putative correlates, grading the quality of evidence. Results: We included 43 studies, based on 38 independent samples. Attention deficit hyperactivity disorder participants were more likely to be males (odds ratio = 1.46; p < 0.001) and unemployed (odds ratio = 1.45; p = 0.045), and less likely to be married (odds ratio = 0.62; p = 0.014). They had an earlier onset of bipolar disorder (standardized mean difference = −0.36; p < 0.001); more mood episodes (standardized mean difference = 0.35; p = 0.007), particularly depressive (standardized mean difference = 0.30; p = 0.011) and mixed (standardized mean difference = 0.30; p = 0.031) ones; higher odds of using antidepressants (odds ratio = 1.80; p = 0.024) and attempted suicides (odds ratio = 1.83; p < 0.001) and lower odds of psychotic features (odds ratio = 0.63; p = 0.010). Moreover, they were more likely to have generalized anxiety disorder (odds ratio = 1.50; p = 0.019), panic disorder (odds ratio = 1.89; p < 0.001), social phobia (odds ratio = 1.61; p = 0.017), eating disorders (odds ratio = 1.91; p = 0.007), antisocial personality disorder (odds ratio = 3.59; p = 0.004) and substance (odds ratio = 2.29; p < 0.001) or alcohol (odds ratio = 2.28; p < 0.001) use disorders. Quality of the evidence was generally low or very low for the majority of correlates, except for bipolar disorder onset and alcohol/substance use disorders (high), and suicide attempts (moderate). Conclusion: Comorbid bipolar disorder/attention deficit hyperactivity disorder may have some distinctive clinical features including an earlier onset of bipolar disorder and higher comorbid alcohol/substance use disorder rates. Further research is needed to identify additional clinical characteristics of this comorbidity.

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Section: Resultsmentioning

confidence: 99%

Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis

Bartoli

Callovini

Cavaleri

et al. 2022

Aust N Z J Psychiatry

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“…Table 1 summarizes the main characteristics of included studies divided according to the age of the individuals enrolled in the sample (children/adolescents or adults) and setting (population- or hospital-based) [ 15 , 16 , 17 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ,…”

Section: Resultsmentioning

confidence: 99%

“…With respect to hospital-based studies in adult populations, we identified a huge comorbidity frequency variation, with lifetime prevalence of comorbid OCD diagnosis in patients affected by BD ranged between 1.8% (n = 55) [ 55 ] and 100% in four studies (n = 56; n = 58; n = 64; n = 79) [ 66 , 87 , 88 , 89 ], although 6 studies out of 41 did not report the prevalence data [ 44 , 52 , 85 , 86 , 98 , 104 ]. Restricting the analysis to the eleven studies with a sample size greater than 250 individuals [ 36 , 37 , 58 , 62 , 64 , 65 , 73 , 78 , 91 , 93 , 95 ], the comorbidity prevalence range was slightly lower (3–23.2%) with a mean of 379.1 participants. Finally, when considering hospital-based studies including children and adolescents populations the prevalence data ranged between 2.4% (n = 85) [ 117 ] and 46.9% (n = 115) [ 108 ], with two other studies which achieved 20.7% (n = 82) [ 109 ] and 24.7% (n = 93) [ 119 ] respectively.…”

Section: Resultsmentioning

confidence: 99%

“…However, it is noteworthy that the sole study that identified a more severe and persistent course of OCD in patients with both OCD and BD was conducted within a small cohort consisting mostly of 15 women, primarily diagnosed with BD-I [ 59 ], while a few studies did not identify any difference in illness duration [ 49 , 62 , 93 ]. Additionally, four separate studies involving BD patients revealed a higher incidence of a chronic or longer course of BD in those with comorbid OCD in comparison to patients without this comorbidity [ 36 , 60 , 64 , 68 ]. Furthermore, in various studies, the majority of BD-OCD subjects either experienced OCD exclusively during their depressive episodes or reported worsening of their OCD symptoms during periods of depression [ 90 , 105 ], with a study reporting improvement or remission during mania/hypomania phases [ 90 ].…”

Section: Resultsmentioning

confidence: 99%

“…As indicated in Table 5 , research conducted with both adult and pediatric patients consistently found that the coexistence of BD and OCD was linked to diminished functioning and a lower quality of life across all domains, including physical, psychological, social, educational, working and environmental aspects, in comparison to individuals with either ‘pure’ BD or ‘pure’ OCD [ 16 , 23 , 27 , 36 , 63 , 64 , 73 , 93 , 95 , 100 , 110 , 111 , 113 ]. Two hospital-based studies also observed similar trends, although they did not reach statistical significance [ 45 , 74 ].…”

Section: Resultsmentioning

confidence: 99%

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Obsessive–Compulsive Disorder as an Epiphenomenon of Comorbid Bipolar Disorder? An Updated Systematic Review

de Filippis,

Aguglia,

Costanza

et al. 2024

JCM

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Background: Bipolar disorder (BD) and obsessive–compulsive disorder (OCD) comorbidity is an emerging condition in psychiatry, with relevant nosological, clinical, and therapeutic implications. Methods: We updated our previous systematic review on epidemiology and standard diagnostic validators (including phenomenology, course of illness, heredity, biological markers, and treatment response) of BD-OCD. Relevant papers published until (and including) 15 October 2023 were identified by searching the electronic databases MEDLINE, Embase, PsychINFO, and Cochrane Library, according to the PRISMA statement (PROSPERO registration number, CRD42021267685). Results: We identified 38 new articles, which added to the previous 64 and raised the total to 102. The lifetime comorbidity prevalence ranged from 0.26 to 27.8% for BD and from 0.3 to 53.3% for OCD. The onset of the two disorders appears to be often overlapping, although the appearance of the primary disorder may influence the outcome. Compared to a single diagnosis, BD-OCD exhibited a distinct pattern of OC symptoms typically following an episodic course, occurring in up to 75% of cases (vs. 3%). Notably, these OC symptoms tended to worsen during depressive episodes (78%) and improve during manic or hypomanic episodes (64%). Similarly, a BD course appears to be chronic in individuals with BD-OCD in comparison to patients without. Additionally, individuals with BD-OCD comorbidity experienced more depressive episodes (mean of 8.9 ± 4.2) compared to those without comorbidity (mean of 4.1 ± 2.7). Conclusions: We found a greater likelihood of antidepressant-induced manic/hypomanic episodes (60% vs. 4.1%), and mood stabilizers with antipsychotic add-ons emerging as a preferred treatment. In line with our previous work, BD-OCD comorbidity encompasses a condition of greater nosological and clinical complexity than individual disorders.

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Schizophrenia and co-morbid obsessive - compulsive disorder: Clinical characteristics

Bener

Dafeeah

Abou‐Saleh

et al. 2018

Asian Journal of Psychiatry

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Comorbid obsessive-compulsive disorder and bipolar disorder in a highly endogamous population: which came first?

Cited by 3 publications

References 25 publications

Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis

Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis

Obsessive–Compulsive Disorder as an Epiphenomenon of Comorbid Bipolar Disorder? An Updated Systematic Review

Schizophrenia and co-morbid obsessive - compulsive disorder: Clinical characteristics

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