Comorbid infections in patients with systemic lupus erythematosus: State-of-the-art

Белов, Б. С.; Соловьев, С. К.; Клюквина, Н. Г.; Тарасова, Г. М.; Полянская, М. В.

doi:10.14412/1995-4484-2016-469-477

Cited by 2 publications

(2 citation statements)

References 46 publications

(52 reference statements)

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“…Uncommonly, patient anamnesis included systemic lupus erythematosus (SLE). Immunodeficiencies in patients with SLE compromise the immunity so that conditional pathogens (fungal, bacterial, viral) can contribute to the infection development [20], [21]. In this case, additional methods for microbial detection are needed.…”

Section: Discussionmentioning

confidence: 99%

Challenging Diagnostics of Biofilm Associated Periprosthetic Infection in Immunocompromised Patient: A Clinical Case

Науменко¹,

Силантьева²,

Ермаков³

et al. 2019

Open Access Maced J Med Sci

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Abstract BACKGROUND: Periprosthetic joint infection (PJI) is a devastating complication of joint arthroplasty. The identification of microorganisms in biofilm-related PJI is challenging yet significant stage of the treatment process. Medical microbiology methods, such as pure culture isolation, remain the gold standard. However, the error rate of classical methods may vary from 10% to as high as 42% due to the inability to detect bacteria growing within biofilms. Other methods of detection are being explored to improve the management of PJI. AIM: Accurate identification of PJI contributing microorganisms in a patient with acute postoperative PJI after total hip joint arthroplasty and systemic lupus erythematosus in anamnesis. METHODS: We used microbial culture methods followed by scanning electron microscopy (SEM). RESULTS: Perioperative an intraoperative cultural analysis of 8 different culture samples of tissue and prosthetic origin was insufficient for bacterial or fungal detection. Scanning electron microscopy revealed detailed biofilm visualisation on the surface of the prosthetic component. The biofilm exterior was composed of microbial clusters made of 10 or more cells with either pear- or bottle-shaped morphology, 3-6 mcm in length and 1.5-3 mcm in diameter. Rod-shaped microorganisms of 0.7-1 mcm length and up to 0.5 mcm in diameter were found adjacent to these clusters. CONCLUSION: Additional methods for PJI agents’ detection are time-and cost-effective in the case of the challenging diagnostics of biofilm-related PJI, particularly in immunocompromised patients. Using combined diagnostic approaches increases the accuracy of detection, justifies treatment strategies and improves clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Challenging Diagnostics of Biofilm Associated Periprosthetic Infection in Immunocompromised Patient: A Clinical Case

Науменко¹,

Силантьева²,

Ермаков³

et al. 2019

Open Access Maced J Med Sci

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“…По данным литературы вероятность летальных исходов при СКВ в 2-5 раз выше, чем в популяции. Одним из факторов неблагоприятного прогноза является присоединение инфекционных осложнений (ИО) [3]. По данным ревматологического отделения ГУЗ «Областная клиническая больница» (г. Саратов) среди 8 умерших в 2018 году в стационаре пациентов 3 имели диагноз «Системная красная волчанка».…”

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Infectious complications as predictors of adverse outcome in a patient with systemic lupus erythematosus (clinical case)

Никитина

Aleksandrova

Скрябина

et al. 2019

Arhivʺ vnutrennej mediciny

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Comorbid infections in patients with systemic lupus erythematosus: State-of-the-art

Cited by 2 publications

References 46 publications

Challenging Diagnostics of Biofilm Associated Periprosthetic Infection in Immunocompromised Patient: A Clinical Case

Challenging Diagnostics of Biofilm Associated Periprosthetic Infection in Immunocompromised Patient: A Clinical Case

Infectious complications as predictors of adverse outcome in a patient with systemic lupus erythematosus (clinical case)

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