Comorbid alcohol use and post-traumatic stress disorders: Pharmacotherapy with aldehyde dehydrogenase 2 inhibitors versus current agents

Morice, Claire; Yammine, Luba; Yoon, Jin Sang; Lane, Scott D.; Schmitz, Joy M.; Kosten, Thomas R.; Garza, Richard De La; Verrico, Christopher D.

doi:10.1016/j.pnpbp.2021.110506

Cited by 3 publications

(3 citation statements)

References 140 publications

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“…98 Substance abuse disorders, including alcohol use disorder (AUD), are frequently comorbid with anxiety and stress disorders. 99,100 It has been reported that Adcy2 is downregulated in the hippocampus of rats with an innate preference for alcohol. 101 There are currently no data on a specific role of Adcy2 in AUD.…”

Section: Stress-associated Disordersmentioning

confidence: 99%

Adenylyl cyclase 2 expression and function in neurological diseases

Gray,

Nash,

Yao

2024

CNS Neurosci Ther

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Adenylyl cyclases (Adcys) catalyze the formation of cAMP, a secondary messenger essential for cell survival and neurotransmission pathways in the CNS. Adcy2, one of ten Adcy isoforms, is highly expressed in the CNS. Abnormal Adcy2 expression and mutations have been reported in various neurological disorders in both rodents and humans. However, due to the lack of genetic tools, loss‐of‐function studies of Adcy2 are scarce. In this review, we summarize recent findings on Adcy2 expression and function in neurological diseases. Specifically, we first introduce the biochemistry, structure, and function of Adcy2 briefly. Next, the expression and association of Adcy2 in human patients and rodent models of neurodegenerative diseases (Alzheimer's disease and Parkinson's disease), psychiatric disorders (Tourette syndrome, schizophrenia, and bipolar disorder), and other neurological conditions (stress‐associated disorders, stroke, epilepsy, and Lesch‐Nyhan Syndrome) are elaborated. Furthermore, we discuss the pros and cons of current studies as well as key questions that need to be answered in the future. We hope to provide a focused review on Adcy2 that promotes future research in the field.

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Section: Stress-associated Disordersmentioning

confidence: 99%

Adenylyl cyclase 2 expression and function in neurological diseases

Gray,

Nash,

Yao

2024

CNS Neurosci Ther

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“…Moreover, frailty is common in older people [36], and the occurrence of acute stressors may accelerate unintentional weight loss and decline in physical activity, which could favor the subsequent incidence of low back pain. Finally, coping with PTSD symptoms may be insufficient, and the association between PTSD and incident CLBP may be mediated by several unhealthy behaviors (e.g., smoking [23,24] and alcohol consumption [25,26]).…”

Section: Interpretation Of Findingsmentioning

confidence: 99%

“…PTSD occurs after exposure to a threatening or horrific event (e.g., combat, natural disaster, and witnessing the sudden death of others) and corresponds to symptoms (e.g., re-experiencing the traumatic event, deliberate avoidance of reminders, and persistent perceptions of heightened current threat) lasting at least several weeks [18]. The effects of PTSD on CLBP could be mediated by multiple factors, such as low-grade inflammation [19,20], insufficient physical activity [21,22], smoking [23,24], and alcohol consumption [25,26]. Although the previous literature has advanced the field, this research displays some limitations that should be acknowledged.…”

Section: Introductionmentioning

confidence: 99%

Is There an Association between Post-Traumatic Stress Disorder and the Incidence of Chronic Low Back Pain?

Kostev,

Smith,

Haro

et al. 2023

JCM

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Background: Preliminary research suggests post-traumatic stress disorder (PTSD) is a risk factor for chronic low back pain (CLBP). However, this literature displays some limitations. Therefore, this study aimed to investigate the association between PTSD and the 10-year cumulative incidence of CLBP in adults from Germany. Methods: The present retrospective cohort study included adults diagnosed with PTSD in 1 of 1284 general practices in Germany in 2005–2020 (index date). Individuals without PTSD were matched to those with PTSD (1:1) using a propensity score based on age, sex, index year, duration of follow-up, and the mean number of consultations during follow-up. In patients without PTSD, the index date was a randomly selected visit date. Results: There were 60,664 patients included in the study. After adjusting for frequent comorbidities, there was a positive but non-significant association between PTSD and incident CLBP in the overall population (HR = 1.07, 95% CI = 0.99–1.15). Nonetheless, the relationship between PTSD and CLBP was statistically significant in the age group >60 years (HR = 1.24, 95% CI = 1.05–1.46). Conclusions: Conversely to previous research, PTSD was not associated with incident CLBP in this large German sample. Further longitudinal studies are warranted to corroborate these findings before drawing any firm conclusions.

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The effect of Lactobacillus plantarum LP-115 strain on improving the savor and aroma of milk containing grape sap through fermentation

Mirsalami

Alihosseini

2023

Food and Humanity

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Comorbid alcohol use and post-traumatic stress disorders: Pharmacotherapy with aldehyde dehydrogenase 2 inhibitors versus current agents

Cited by 3 publications

References 140 publications

Adenylyl cyclase 2 expression and function in neurological diseases

Adenylyl cyclase 2 expression and function in neurological diseases

Is There an Association between Post-Traumatic Stress Disorder and the Incidence of Chronic Low Back Pain?

The effect of Lactobacillus plantarum LP-115 strain on improving the savor and aroma of milk containing grape sap through fermentation

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