¿Cómo incrementar el número de trasplantes hepáticos?

Fondevila, Constantino; Jiménez-Galanes, Santos; García‐Valdecasas, Juan Carlos

doi:10.1016/j.gastrohep.2009.01.184

Cited by 4 publications

(1 citation statement)

References 77 publications

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“…Nowadays, the number of patients suitable for liver transplantation is progressively increasing. This has given rise to a growing imbalance in the number of candidates on the waiting list and the number of donors (4). This situation has prompted scientists to search for alternative approaches in order to increase the number of liver grafts.…”

Section: Introductionmentioning

confidence: 99%

First approaches for the transplantation of hepatocytes from Wistar rat preneoplastic livers into healthy recipients

Vera¹,

Biancardi²,

Bottai³

et al. 2019

Rev Esp Enferm Dig

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Background: the shortage of donors of hepatocyte transplantation therapy led to the use of so-called marginal donors. Some donors may have a hepatic illnesses that is associated with hepatic preneoplasia with foci of altered hepatocytes (FAH). Aims: to determine whether recipients developed FAH upon transplantation with hepatocytes from a preneoplastic liver and whether FAH progresses to a preneoplastic hepatocyte-derived tumor (PHDT), up to 60 days after transplantation. Material and methods: male Wistar adult rats were used as donors and recipients. Donors underwent a 2-phase model of liver preneoplasia for hepatocyte isolation. Recipients underwent a partial two thirds hepatectomy and received 150,000 hepatocytes. Recipients were euthanized seven and 60 days after transplantation. The number of FAH per liver area, percentage of liver occupied by FAH, the hepatic enzymatic profile, the percentage of prothrombin time (PT), the proliferative index (PI) and liver morphology were analyzed. Results: recipients developed few and very isolated FAH. No statistical differences were found between hepatic enzyme activities and PT. There were no differences between the groups with regard to the number of FAH per liver area and percentage of liver occupied by FAH after 60 days. The PI decreased on day 60 compared to day seven. No morphological alterations were found. Conclusions: recipients developed few FAH that did not increase in number or size, nor did they progress to PHDT and had normal plasma biochemical features and liver morphology up to 60 days post-transplant. Additional studies are needed to determine whether FAH development constitutes a risk for recipients while waiting for whole organ transplant.

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Section: Introductionmentioning

confidence: 99%

First approaches for the transplantation of hepatocytes from Wistar rat preneoplastic livers into healthy recipients

Vera¹,

Biancardi²,

Bottai³

et al. 2019

Rev Esp Enferm Dig

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Split/Reduced Liver Transplantation “IMSS”: The First Two Cases and Literature Overview

Aurelus¹,

Yáñez²,

Nagano³

et al. 2017

Arch Organ Transplant

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Introduction: The term Split/Liver Transplantation involved the ex vivo division of an adult cadaver liver into a pediatric allograft and a remnant adult allograft. The efforts were an attempt to satisfy an increasing demand for pediatric cadaver allografts that had resulted in prolonged waiting periods and a wait-list mortality of approximately 50% at major pediatric referral centers. The main of this work is given to know our experience in two different cases and encouraged at the adult surgeons to confi de and accept the right allograft of this technique for an adult patient. Cases: We performed two reduced procedures by the split liver technique. The fi rst case was a procurement of a male donor of 33 years' old with diagnosis of cerebral death due to aneurysm rupture, and the recipient was a fi ve years' old girl with the diagnosis of biliary atresia. For the second case, we had a male donor of 8 years' old with diagnosis of cerebral death secondary to arteriovenous malformation and the recipient was a 2.9 year´s old girl, with biliary atresia. Conclusion: There are no differences in complications between split in cadaveric donor to living liver donor. However for a good outcome, it is important to have a good donor like it is for a good recipient. In our center, the split liver transplantation is uncommon and there is a clear need for better training of surgeons and for improved sharing of information about this needed procedure.

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Split/Reduced Liver Transplantation “IMSS”: The First Two Cases and Literature Overview

Aurelus¹,

Yáñez²,

Nagano³

et al. 2017

Arch Organ Transplant

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¿Cómo incrementar el número de trasplantes hepáticos?

Cited by 4 publications

References 77 publications

First approaches for the transplantation of hepatocytes from Wistar rat preneoplastic livers into healthy recipients

First approaches for the transplantation of hepatocytes from Wistar rat preneoplastic livers into healthy recipients

Split/Reduced Liver Transplantation “IMSS”: The First Two Cases and Literature Overview

Split/Reduced Liver Transplantation “IMSS”: The First Two Cases and Literature Overview

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