Abstract. An asymptotic version of von Neumann's double commutant theorem is proved in which C*-algebras play the role of von Neumann algebras. This theorem is used to investigate asymptotic versions of similarity, reflexivity, and reductivity. It is shown that every nonseparable, norm closed, commutative, strongly reductive algebra is selfadjoint. Applications are made to the study of operators that are similar to normal (subnormal) operators. In particular, if T is similar to a normal (subnormal) operator and «■ is a representation of the C*-algebra generated by I, then ir(T) is similar to a normal (subnormal) operator.1. Introduction. One of the reasons for the success of the theory of von Neumann algebras is J. von Neumann's double commutant theorem [46], which gives an alternate description of the weak closure of a selfadjoint algebra of operators. It is the purpose of this paper to prove an asymptotic version of the double commutant theorem that gives an alternate description of the norm closure of a selfadjoint algebra of operators. This asymptotic double commutant theorem helps to unify asymptotic versions of various operator-theoretic concepts (e.g., similarity, reflexivity, reductivity). Applications are made to the study of operators that are similar to normal (or subnormal) operators. Also a proof is given that a strongly reductive, nonseparable, commutative, norm closed algebra of operators is selfadjoint.Throughout, H denotes a separable, infinite-dimensional complex Hubert space, B(H) denotes the set of operators (bounded linear transformations) on H, and %(H) denotes the set of compact operators on H. Also § denotes a separable, nonempty subset of B(H). However, in §8 the separability