Community Versus Vertically Acquired Neonatal SARS-CoV-2 Infection: The EPICENTRE Cohort Study

Luca, Danièle De; Perkins, Elizabeth; Tingay, David G.

doi:10.1097/inf.0000000000003950

Cited by 3 publications

(6 citation statements)

References 6 publications

(11 reference statements)

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“…Early in the pandemic, asymptomatic infections were identified in 16%–25% of cases [ 28 , 44 ]. Subsequently, for different age clusters within the infant age group from cumulative reviews or individual reports, the frequency of asymptomatic but test-positive patients was 0.8%–46.2% [ 5 , 8 , 11 , 21 , 24 , 45 - 52 ]. When asymptomatic infections gained attention, it was inevitable that some infants would be admitted to the hospital for observation given the thenuncertainty of the clinical course to follow [ 24 ].…”

Section: Covid-19 Among Infantsmentioning

confidence: 99%

“…Various treatments and disease modifiers have been used considerably in pediatric age groups as suggested by observational studies [ 52 , 169 , 170 ]. Where specific antiviral chemotherapy has been administered, the frequency of included infants is relatively small [ 170 , 171 ].…”

Section: Controversy Regarding Infantsmentioning

confidence: 99%

“…28,44) Subsequently, for different age clusters within the infant age group from cumulative reviews or individual reports, the frequency of asymptomatic but test-positive patients was 0.8%-46.2%. 5,8,11,21,24,[45][46][47][48][49][50][51][52] When asymptomatic infections gained attention, it was inevitable that some infants would be admitted to the hospital for observation given the thenuncer tainty of the clinical course to follow. 24) The inclusion of mild infections among those numbers with presumed asymptomatic infections increases these frequencies to the vast majority of patients in a given study.…”

Section: Asymptomatic Versus Symptomatic Diseasementioning

confidence: 99%

“…geogra phic regions and with now considerable cumulative numbers. 3,5,[9][10][11]13,[21][22][23][24]26,[30][31][32]34,41,45,46,48,[51][52][53][58][59][60][61][62] Table 1 details the more common disease features cited to date. Small case series, case reports, and reviews have mostly been consistent.…”

Section: Manifestations Of Infant Infectionmentioning

confidence: 99%

“…27,34,106) Consistent with the latter, other studies that stratified patients by age into <30 days, <6 months, and <1 year groups reported mortality rates of approximately 0.1%-0.5%, 0.4%-0.7%, and 0.5%-2.2%, respectively. 9,10,11,13,23,48,51,52,61,80,109) These studies should also be individually viewed given the heterogeneity of whether the mortality rates were ascribed to all patients with infections versus only those admitted to the hospital. Overall, considerable data suggest that infant deaths from COVID-19 are relatively infrequent.…”

Section: Potential For Infant Mortalitymentioning

confidence: 99%

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COVID-19 among infants: key clinical features and remaining controversies

Cimolai

2024

Clin Exp Pediatr

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Infants aged <1 year represent a seemingly more susceptible pediatric subset for infections. Despite this, coronavirus disease 2019 (COVID-19) infection has not been proven as more serious in this age group (outside the very early neonatal period) than in others. Indeed, a considerable number of asymptomatic infections have been recorded, and the symptoms and morbidity associated with COVID- 19 differ minimally from those of other respiratory viral infections. Whether due to an abundance of caution or truly reduced susceptibility, infections in infants have not raised the same profile as those in other age groups. In addition to direct severe acute respiratory syndrome coronavirus 2 diagnostic tests, laboratory markers that differentiate COVID-19 from other viral infections lack specificity in infants. Gastrointestinal presentations are common, and the neurological complications of infection mirror those of other respiratory viral infections. There have been relatively few reports of infant deaths. Under appropriate precautions, breastfeeding in the context of maternal infections has been associated with tangible but infrequent complications. Vaccination during pregnancy provides protection against infection in infants, at least in the early months of life. Multi-inflammatory syndrome in children and multi-inflammatory syndrome in neonates are commonly cited as variants of COVID-19; however, their clinical definitions remain controversial. Similarly, reliable definitions of long COVID in the infant group are controversial. This narrative review examines the key clinical and laboratory features of COVID-19 in infants and identifies several areas of science awaiting further clarification.

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Section: Covid-19 Among Infantsmentioning

confidence: 99%

Section: Controversy Regarding Infantsmentioning

confidence: 99%

Section: Asymptomatic Versus Symptomatic Diseasementioning

confidence: 99%

Section: Manifestations Of Infant Infectionmentioning

confidence: 99%

Section: Potential For Infant Mortalitymentioning

confidence: 99%

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COVID-19 among infants: key clinical features and remaining controversies

Cimolai

2024

Clin Exp Pediatr

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Differences in clinical characteristics of early-onset and late-onset severe acute respiratory syndrome coronavirus 2 infections in neonates

Wu,

Wang,

Zhao

et al. 2024

Eur J Pediatr

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Differences in clinical characteristics of early-onset and late-onset severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in neonates remain unclear. This study aimed to determine whether there are differences in the main clinical, radiological, and laboratory features of early-onset and late-onset SARS-CoV-2 infections in neonates. This single-center, prospective cohort study enrolled neonates with SARS-CoV-2 infection from December 7, 2022, to January 3, 2023, and evaluated their clinical characteristics during hospitalization. All neonates (N = 58) infected with SARS-CoV-2 within 28 days of birth who were admitted to the neonatal intensive care unit of Taizhou Hospital were included. These neonates were classified into the early-onset (diagnosed within 7 days of birth) and late-onset (diagnosed more than 7 days after birth) groups. The symptoms, treatment, and prognosis of SARS-CoV-2 infection were the main study outcomes. The incidence of hospitalization attributable to SARS-CoV-2 infection was 10.6% (58 of 546 neonates) in Linhai. Sixteen (28%) of the 58 SARS-CoV-2 infections were early-onset cases, and 42 (72%) were late-onset cases. The common symptoms among the late-onset group were fever (p < 0.001) and cough (p < 0.001). Neonates with late-onset SARS-CoV-2 infection (p < 0.001) were significantly more likely to develop pneumonia. Conclusion: The clinical symptoms and rates of pneumonia caused by SARS-CoV-2 infection in neonates differed between the early-onset and late-onset groups. Different clinical management is necessary for neonates with early-onset and late-onset SARS-CoV-2 infections. What is Known:• Neonates are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).• Differences in clinical characteristics of early-onset and late-onset SARS-CoV-2 infections in neonates remain unclear. What is New:• Fever and cough were the most common symptoms among neonates with late-onset infection.• Neonates with late-onset SARS-CoV-2 infection were more likely to develop pneumonia.

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SARS-CoV-2 Infection in Children Less Than Forty Days Hospitalized in Belgium Between 2020 and 2022

Demey,

Bruyneel,

Chatzis

et al. 2024

Pediatric Infectious Disease Journal

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Our study aimed to assess the severity of severe acute respiratory syndrome coronavirus 2 infection in hospitalized infants under 40 days old, across 21 Belgian hospitals between 2020 and 2022. Of the 365 infants studied, 14.2% needed respiratory support. The median hospital stay was 3 days (interquartile range, 2–4), and there were no deaths. Infection severity was similar during the Omicron and Alpha/Delta periods.

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Community Versus Vertically Acquired Neonatal SARS-CoV-2 Infection: The EPICENTRE Cohort Study

Cited by 3 publications

References 6 publications

COVID-19 among infants: key clinical features and remaining controversies

COVID-19 among infants: key clinical features and remaining controversies

Differences in clinical characteristics of early-onset and late-onset severe acute respiratory syndrome coronavirus 2 infections in neonates

SARS-CoV-2 Infection in Children Less Than Forty Days Hospitalized in Belgium Between 2020 and 2022

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