Community- versus nosocomial-acquired severe sepsis and septic shock in patients admitted to a tertiary intensive care in Saudi Arabia, etiology and outcome

Baharoon, Salim; Telmesani, Ayman; Tamim, Hani; Alsafi, Eiman; Aljohani, Sara; Mahmoud, Ebrahim; Al‐Jahdali, Hamdan

doi:10.1016/j.jiph.2014.12.003

Cited by 18 publications

(23 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of SS cases were hospital-acquired, corroborating with the results of Baharoon et al on the epidemiology of sepsis in an tertiary ICU of Saudi Arabia. 22 Similarly to Baharoon et al in Saudi Arabia, 22 the main comorbidities were hypertension followed by diabetes. Also, like previous reports, 11,12,19,21 the most common sites of infection responsible for SS were the lungs followed by the abdomen.…”

Section: Discussionmentioning

confidence: 81%

The Epidemiology, Therapeutic Patterns, Outcome, and Challenges in Managing Septic Shock in a Sub-Saharan African Intensive Care Unit: A CrossSectional Study

et al. 2019

View full text Add to dashboard Cite

Background: Septic shock (SS) is a health priority in sub-Saharan Africa. However, there is a dearth of data in this regard. Objective: This study aimed to determine the epidemiology, therapeutic patterns, outcome, and challenges in managing SS in a tertiary intensive care unit (ICU) of sub-Saharan Africa. Methods: The hospital files of 36 consecutive patients admitted to the ICU of the Douala General Hospital (DGH), Cameroon over the year 2018 were reviewed for SS. SS was diagnosed based on Sepsis-3 definition. Demographic and clinical characteristics, treatment details, and outcomes of patients with SS were reviewed. Data was analyzed using the chi-square or Fisher exact tests and Bonferroni correction. Results: SS accounted for 36 (9.4%) ICU admissions. The majority of patients were males (63.9%). The most common site of infection was the lungs. The mean age, average mean arterial pressure (MAP), and mean sequential organ failure assessment (SOFA) score of patients were 52.9±25.2 years, 52±18 mm Hg, and 9.2 ±2.3, respectively. Noradrenaline was the sole vasopressor used. Therapeutic challenges included the inability to have a specific antibiogram before a mean duration of 7 days. The mortality rate was 39% and associated with age ≤1 year, MAP ≤ 65 mm Hg, Glasgow Coma Score (GCS) ≤8, and mechanical ventilation, which were not attenuated after Bonferroni correction. Conclusion: SS is a frequent cause of ICU admission and is associated with a high mortality rate. SS mortality-related factors can be screened during SS management for more aggressive ICU management geared at preventing death.

show abstract

Section: Discussionmentioning

confidence: 81%

The Epidemiology, Therapeutic Patterns, Outcome, and Challenges in Managing Septic Shock in a Sub-Saharan African Intensive Care Unit: A CrossSectional Study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Sepsis is a life-threatening disease that requires early recognition and immediate management. A local study conducted at the National Guard Hospital in Riyadh, Saudi Arabia, showed that the mortality rates for sepsis and septic shock were higher than the reported global mortality rates approaching 60% 1 . Internationally, the incidence and severity of sepsis reveal a rising pattern 2 , 3 .…”

Section: Introductionmentioning

confidence: 95%

<p>National Early Warning Score (NEWS) as Prognostic Triage Tool for Septic Patients</p>

Almutary¹,

Althunayyan²,

Alenazi³

et al. 2020

IDR

View full text Add to dashboard Cite

Purpose We assessed the National Early Warning Score (NEWS) in emergency triage for predicting sepsis-related outcomes. Methods A retrospective chart review of all cases enrolled in the sepsis management protocol for a one-year duration. The protocol utilized the NEWS as a screening tool for sepsis in the triage area. Primary outcomes of interest were hyperlactatemia, admission to ICU and intrahospital mortality. Sensitivity, specificity, and area under the curve (AUC) were calculated for a given NEWS. Results A total of 444 patients were reviewed from July 2018 to June 2019, with a mean age of 58.7 years. A NEWS ≥5 was more than 88% sensitive in predicting hyperlactatemia, ICU admission, and/or mortality. Specificity, on the other hand, was as low as 12%. The AUC for the NEWS was 0.667 for predicting hyperlactatemia and 0.602 for predicting ICU admission or mortality. Conclusion The NEWS was a sensitive screening tool for predicting sepsis-related outcomes. However, it was not specific, and further studies are recommended to assess the integration of other factors to improve specificity.

show abstract

“…[3,29,30] In the present work, blood cultures were positive in 22.7% of septic patients, with slight predominance of Gram-positives. In general, the positivity of blood cultures can vary from 12.5% to no more than 40 % even in cases with septic shock [31,32,33,34]. There are many explanations why the yield of blood cultures in septic patients is so low.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Community-Acquired Sepsis in Adult Patients: A Six Year Observational Study

Grozdanovski

Milenkovikj

Demiri

et al. 2018

Prilozi

View full text Add to dashboard Cite

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to an infection and it is a major cause of morbidity and mortality worldwide. The aim of this study is to describe epidemiology of community-acquired sepsis in the Intensive care unit (ICU) of the Macedonian tertiary care University Clinic for Infectious Diseases. A prospective observational study was conducted over a 6-year period from January, 2011 to December, 2016. All consecutive adults with community-acquired sepsis or septic shock were included in the study. Variables measured were incidence of sepsis, age, gender, comorbidities, season, source of infection, complications, interventions, severity indexes, length of stay, laboratory findings, blood cultures, 28-day and in hospital mortality. Of 1348 admissions, 277 (20.5%) had sepsis and septic shock. The most common chronic condition was heart failure (26.4%), and the most frequent site of infection was the respiratory tract (57.4%). Median Simplified Acute Physiology Score (SAPS II) was 50.0, and median Sequential Organ Failure Assessment (SOFA) score was 8.0. Blood cultures were positive in 22% of the cases. Gram-positive bacteria were isolated in 13% and Gram-negatives in 9.7% of patients with sepsis. The overall 28-day and in hospital mortality was 50.5% and 56.3% respectively. The presence of chronic heart failure, occurrence of ARDS, septic shock and the winter period may influence an unfavorable outcome. Mortality compared to previous years is unchanged but patients that we have been treating these last 6 years have had more severe illnesses. Better adherence to the Surviving Sepsis guidelines will reduce mortality in this group of severely ill patients.

show abstract

Community- versus nosocomial-acquired severe sepsis and septic shock in patients admitted to a tertiary intensive care in Saudi Arabia, etiology and outcome

Abstract: Both community and hospital-acquired infections carry high mortality. Hospital-acquired severe sepsis is frequent in medical wards and ICUs, and measures to further evaluate risk factors are prudent.

Cited by 18 publications

References 17 publications

The Epidemiology, Therapeutic Patterns, Outcome, and Challenges in Managing Septic Shock in a Sub-Saharan African Intensive Care Unit: A CrossSectional Study

The Epidemiology, Therapeutic Patterns, Outcome, and Challenges in Managing Septic Shock in a Sub-Saharan African Intensive Care Unit: A CrossSectional Study

<p>National Early Warning Score (NEWS) as Prognostic Triage Tool for Septic Patients</p>

Epidemiology of Community-Acquired Sepsis in Adult Patients: A Six Year Observational Study

Contact Info

Product

Resources

About