Community structure of non-coding RNA interaction network

Nacher, Jose C.

doi:10.2390/biecoll-jib-2013-217

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…RNA can be classified into two categories according to its function of encoding proteins — mRNA, which encodes proteins, and ncRNA, which is not capable of encoding proteins. Although ncRNAs cannot encode proteins, their content in the human gene transcriptome is more than 98% ( Zhang et al., 2019 ), indicating that ncRNAs might have rich biological functions in living organisms ( Nacher, 2013 ). Based on their molecular size, ncRNAs can be further divided into long ncRNAs (lncRNAs; length ≥200 nucleotides) and small ncRNAs (sncRNAs; length <200 nucleotides).…”

Section: Mechanisms Of the Ncrna-mediated Regulation Of Osteogenic Si...mentioning

confidence: 99%

Non-coding RNA delivery for bone tissue engineering: Progress, challenges, and potential solutions

Guan¹,

Zhang²,

Wu³

2022

iScience

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Section: Mechanisms Of the Ncrna-mediated Regulation Of Osteogenic Si...mentioning

confidence: 99%

Non-coding RNA delivery for bone tissue engineering: Progress, challenges, and potential solutions

Guan¹,

Zhang²,

Wu³

2022

iScience

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Long noncoding RNA PEG10 regulates proliferation and invasion of esophageal cancer cells

et al. 2015

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Long chain noncoding RNAs (LncRNAs), a class of noncoding RNA nucleotides longer than 200 bp, have important roles in a variety of biological processes. Accumulating evidence has confirmed the involvement of LncRNAs in cancer initiation, development and progression. We investigated the expression of LncRNA PEG10 in a cohort of esophageal carcinomas to assess its impact on esophageal cancer cell proliferation, apoptosis and invasion. Quantitaive reverse transcription polymerase chain reaction assays were used to quantify LncRNA PEG10 expression levels in 43 paired EC samples and adjacent non-neoplastic tissues. Cell growth, apoptosis and Transwell invasion assays were used to evaluate the effects of LncRNA PEG10 on esophageal cancer cells. LncRNA PEG10 was expressed at higher levels in esophageal cancer tissues than in adjacent non-neoplastic tissues (P<0.05). This relatively high expression was significantly associated with the occurrence of lymph node metastases (P<0.05). Apoptosis and migration rates were significantly decreased in two esophageal cancer cell lines (EC9706 and KYSE150) transfected with si-LncRNA PEG10 (P<0.05). Downregulation of LncRNA PEG10 decreased the expression of PEG10 (P<0.05). Our results indicated that LncRNA PEG10 is upregulated in esophageal cancer tissues, and its downregulation inhibits proliferation and invasion, and promotes apoptosis in esophageal cancer cells. LncRNA PEG10 may serve as a therapeutic agent in esophageal cancer.

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Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation

Clahsen

Büttner

Hatami

et al. 2020

JCM

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Under normal conditions, the cornea, being the transparent "windscreen" of the eye, is free of both blood and lymphatic vessels. However, various diseases of the eye, like infections, can interfere with the balance between promoting and inhibiting factors, which leads to ingrowth of blood and lymphatic vessels. The newly formed lymphatic vessels increase the risk of graft rejection after subsequent corneal transplantation. Corneal transplantation is one of the most commonly performed transplantations worldwide, with more than 40,000 surgeries per year in Europe. To date, various anti-hem-and anti-lymphangiogenic treatment strategies have been developed specifically for the corneal vascular endothelial growth factor (VEGF) pathway. Currently, however, no treatment strategies are clinically available to specifically modulate lymphangiogenesis. In this review, we will give an overview about endogenous regulators of hem-and lymphangiogenesis and discuss potential new strategies for targeting pathological lymphangiogenesis. Furthermore, we will review recently identified modulators and demonstrate that the cornea is a suitable model for the identification of novel endogenous modulators of lymphangiogenesis. The identification of novel modulators of lymphangiogenesis and a better understanding of the signaling pathways involved will contribute to the development of new therapeutic targets for the treatment of pathological lymphangiogenesis. This, in turn, will improve graft rejection, not only for the cornea.

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Community structure of non-coding RNA interaction network

Cited by 3 publications

References 17 publications

Non-coding RNA delivery for bone tissue engineering: Progress, challenges, and potential solutions

Non-coding RNA delivery for bone tissue engineering: Progress, challenges, and potential solutions

Long noncoding RNA PEG10 regulates proliferation and invasion of esophageal cancer cells

Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation

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