Community-level SARS-CoV-2 Seroprevalence Survey in urban slum dwellers of Buenos Aires City, Argentina: a participatory research

Figar, Silvana; Pagotto, Vanina; Luna, Lorena; Salto, Julieta; Manslau, Magdalena Wagner; Mistchenko, Alicia; Gamarnik, Andrea V.; Saldaño, Ana María Gómez; Quirós, Fernán González Bernaldo de

doi:10.1101/2020.07.14.20153858

Cited by 37 publications

(58 citation statements)

References 14 publications

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“…The same proportion of studies validated their methods internally to report accuracy (16,21,23,24,30,32,(34)(35)(36)(37)(38)(39)45,50,52) or used sensitivity and specificity given by manufacturers or other external studies (18)(19)(20)22,36,(40)(41)(42)(44)(45)(46)(47)(48)(49)(50)(51). We also noticed that it is quite unclear if the field teams followed standardized protocols for the data collection and testing.…”

Section: Discussionmentioning

confidence: 99%

Population-based prevalence surveys during the COVID-19 pandemic: a systematic review

Franceschi

Santos

Glaeser

et al. 2020

Preprint

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Population-based prevalence surveys of COVID-19 contribute to establish the burden and epidemiology of infection, the role of asymptomatic and mild infections in transmission, and allow more precise decisions about reopen policies. We performed a systematic review to evaluate qualitative aspects of these studies, their reliability, and biases. The available data described 37 surveys from 19 countries, mostly from Europe and America and using antibody testing. They reached highly heterogeneous sample sizes and prevalence estimates. Disproportional prevalence was observed in minority communities. Important risk of bias was detected in four domains: sample size, data analysis with sufficient coverage, measurements in standard way, and response rate. The correspondence analysis showed few consistent patterns for high risk of bias. Intermediate risk of bias was related to American and European studies, blood samples and prevalence >1%. Low risk of bias was related to Asian studies, RT-PCR tests and prevalence <1%.

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Section: Discussionmentioning

confidence: 99%

Population-based prevalence surveys during the COVID-19 pandemic: a systematic review

Franceschi

Santos

Glaeser

et al. 2020

Preprint

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“…The City of Buenos Aires, adopted a "test and trace" policy. This program was carried out more strongly in poor neighborhoods, which have a younger population [12]. Mandatory hospitalization was also established for infants, still asymptomatic [6] [13].…”

Section: Discussionmentioning

confidence: 99%

Children hospitalized for COVID-19 during the first winter of the pandemic in Buenos Aires, Argentina

Raiden

Cairoli

Potasnik

et al. 2020

Preprint

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Background: Although there are reports on COVID-19 in pediatrics, it is possible that the characteristics of each population, their health systems and how they faced the pandemic made the disease show distinctive features in different countries. We aimed to describe the characteristics of patients hospitalized for COVID-19 in a tertiary pediatric hospital in the City of Buenos Aires, Argentina. Methods: Descriptive study, including all patients hospitalized for COVID-19 in a tertiary pediatric hospital, from 04/26/2020 to 10/31/2020. Demographic, clinical and epidemiological characteristics of the patients are described. Results: In the studied period 578 children and adolescents were hospitalized for COVID-19. The median age was 4.2 years and 83% had a history of close contact with a confirmed COVID-19 case. Regarding severity, 30.8% were asymptomatic, 60.4% mild, 7.4% moderate, and 1.4% severe. Among those with symptoms, the most frequent was fever, followed by sore throat and cough. Conclusion: We reported 578 cases of children and adolescents hospitalized for COVID-19, most of them showed a mild or asymptomatic condition.

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“…Serological studies in different regions in England, Rio de Janeiro, Brazil, Tokyo, Japan, as well as Heinsberg, Germany estimate that SARS-CoV-2 seroprevalence is highest in adults aged under 35y ( 5 – 8 ). A serological study in a slum community in Buenos Aires, Argentina found the highest seroprevalence to be in adolescents aged 14-19y ( 25 ). In Belgium, persons aged 20-30 years had the highest estimated seroprevalence in persons aged below 80 ( 24 ) (with the oldest individuals likely affected by outbreaks in long-term care facilities).…”

Section: Age Variation In Seroprevalencementioning

confidence: 99%

On the effect of age on the transmission of SARS-CoV-2 in households, schools and the community

Goldstein

Lipsitch

Çevik

2020

Preprint

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Background: There is limited information on the effect of age on the transmission of SARS-CoV-2 infection in different settings, including primary, secondary and high schools, households, and the whole community. We undertook a literature review of published studies/data on detection of SARS-CoV-2 infection in contacts of COVID-19 cases, as well as serological studies, and studies of infections in the school setting to examine those issues. Results: Our literature review presents evidence for significantly lower susceptibility to infection for children aged under 10 years compared to adults given the same exposure, for elevated susceptibility to infection in adults aged over 60y compared to younger/middle aged adults, and for the risk of SARS-CoV-2 infection associated with sleeping close to an infected individual. Published serological studies also suggest that younger adults (particularly those aged under 35y) often have high cumulative rates of SARS-CoV-2 infection in the community. Additionally, there is some evidence of robust spread of SARS-CoV-2 in secondary/high schools, and there appears to be more limited spread in primary schools. Some countries with relatively large class sizes in primary schools (e.g. Chile and Israel) reported sizeable outbreaks in some of those schools, though routes of transmission of infection to both students and staff are not clear from current reports. Conclusions: Opening secondary/high schools is likely to contribute to the spread of SARS-CoV-2, and, if implemented, it should require both lower levels of community transmission and greater safeguards to reduce transmission. Compared to secondary/high schools, opening primary schools and daycare facilities may have a more limited effect on the spread of SARS-CoV-2 in the community, particularly under smaller class sizes and in the presence of mitigation measures. Efforts to avoid crowding in the classroom and other mitigation measures should be implemented, to the extent possible, when opening primary schools. Efforts should be undertaken to diminish the mixing in younger adults to mitigate the spread of the epidemic in the whole community.

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Community-level SARS-CoV-2 Seroprevalence Survey in urban slum dwellers of Buenos Aires City, Argentina: a participatory research

Cited by 37 publications

References 14 publications

Population-based prevalence surveys during the COVID-19 pandemic: a systematic review

Population-based prevalence surveys during the COVID-19 pandemic: a systematic review

Children hospitalized for COVID-19 during the first winter of the pandemic in Buenos Aires, Argentina

On the effect of age on the transmission of SARS-CoV-2 in households, schools and the community

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