Community Identification of Natural Health Product–Drug Interactions

Charrois, Theresa L.; Hill, Richard L.; Vu, Duc; Foster, Brian; Boon, Heather; Cramer, Kristie; Vohra, Sunita

doi:10.1345/aph.1h463

Cited by 50 publications

(53 citation statements)

References 20 publications

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“…A report released by Health Canada in 2005 estimated that 71 % of the Canadian population uses NHPs on a daily basis (1). At the same time a Canadian survey reported that 47% of those who use prescription drugs and natural health products together had adverse effects ranging from mild to severe rashes and serious effects by those who used blood thinners etc (2). Both functional foods and NHPs selected for health benefits contain bioactive secondary metabolites but their roles in promoting human health has not been thoroughly studied (3).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and P450 Inhibitory Properties of Common Functional Foods

et al. 2014

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-PURPOSE: To study the effect of functional foods on human cytochrome P450 (CYP) and the gut bacterial microflora that may potentially affect drug metabolism and ultimately affect human health and wellness. METHODS: This study examined a variety of food plants from the Apiaceae, Fabaceae, and Lamiaceae families for their inhibitory potential on cytochrome 2D6-, 3A4-, 3A5-, and 3A7-mediated metabolism. The antimicrobial effects of these samples were also investigated with 7 selected bacterial surrogate species to determine potential effects on the gut microflora. RESULTS: The highest CYP inhibitory activities, based upon visual examination, were observed from extracts of celery seed, cumin, fennel seed, basil, oregano, and rosemary belonging to the Apiaceae and Lamiaceae families, respectively. Likewise, the strongest antimicrobial activities were also observed in the Apiaceae and Lamiaceae. No significant antimicrobial and CYP inhibition was observed in the Fabaceae extracts. CONCLUSION: Results demonstrated the possible risk of food-drug interactions from spice and herb plants may affect drug disposition and safety.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial and P450 Inhibitory Properties of Common Functional Foods

et al. 2014

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“…47 • Adverse events from NHP use, although infrequent, are more common than reported. 11, 48 All involved in patient care should be encouraged to report adverse events regardless of whether they are from conventional care, NHP/CAM use, or interaction of the two. Institutions should implement systems to prevent recurrence.…”

Section: Patient Safetymentioning

confidence: 99%

Natural Health Product–Drug Interactions: Evolving Responsibilities to Take Complementary and Alternative Medicine Into Account

Gilmour

Harrison

Asadi³

et al. 2011

Pediatrics

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Natural health products (NHPs) (known as dietary supplements in the United States) are a popular form of self-care, yet many patients do not disclose their use to clinicians. NHP-drug interactions are known to occur and can harm patients and affect the efficacy of conventional treatment. Using the example of an HIV-positive adolescent who had been responding well to antiretroviral therapy but then experienced a sudden unexplained deterioration in her condition, we review (1) clinicians' obligation to inquire about complementary and alternative medicine (CAM) use when assessing, treating, and monitoring patients, (2) how clinicians' duty to warn about risks associated with treatment has evolved and expanded, and (3) patients' and parents' responsibility to disclose CAM use. It also addresses the responsibility of hospitals and health facilities to ensure that the reality of widespread CAM/NHP use is taken into account in patient care to effectively protect patients from harm.

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“…In a study of community pharmacists in England, 11% of the 818 respondents had identified or been informed by patients/consumers of adverse events associated with the use of complementary medicines (at least 60% related to herbal medicines, including traditional Chinese herbal medicines) [60]. In a similar study of community pharmacists in Canada, 47% of the 132 respondents stated that they had identified a potential interaction between a conventional drug and a natural health product [61]. In a prospective observational cohort study in 131 medical practices in Germany and 662 consecutive out-patients, patient-reported and physician-assessed adverse events associated with anthroposophical medicines (which include herbal and/or mineral ingredients) were monitored for 2 years [62].…”

Section: Frequency Of Adverse Reactionsmentioning

confidence: 99%

Adverse Drug Reactions and Pharmacovigilance of Herbal Medicines

Barnes

2011

Stephens' Detection and Evaluation of Adverse Drug Reactions

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Community Identification of Natural Health Product–Drug Interactions

Cited by 50 publications

References 20 publications

Antimicrobial and P450 Inhibitory Properties of Common Functional Foods

Antimicrobial and P450 Inhibitory Properties of Common Functional Foods

Natural Health Product–Drug Interactions: Evolving Responsibilities to Take Complementary and Alternative Medicine Into Account

Adverse Drug Reactions and Pharmacovigilance of Herbal Medicines

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