“…Community water fluoridation and the use of fluoride products (toothpastes, mouthwashes, varnishes and fluoride gel) associated with oral hygiene care has been proven to decrease caries incidence in children and adolescents ,,,,. Indeed, the use of fluoride is part of most preventive programmes,,,,, such as the Baby Clinic programme. In order to avoid bias regarding water fluoride exposition, we included only patients and controls who lived in the Londrina metropolitan region, and had access to fluoride water in childhood and adulthood.…”