Community-based monitoring of diarrhea in urban Brazilian children: incidence and associated pathogens

Barreto, Maurício Lima; Milroy, Craig; Strina, Agostino; Prado, Matildes da Silva; Leite, José Paulo Gagliardi; Ramos, Eduardo Antônio Gonçalves; Ribeiro, Hugo; Alcântara-Neves, Neuza Maria; Teixeira, Maria da Glória Lima Cruz; Rodrigues, Laura C.; Ruf, Hilda; Guerreiro, Hygia; Trabulsi, Luíz Rachid

doi:10.1016/j.trstmh.2005.03.010

Cited by 38 publications

(39 citation statements)

References 23 publications

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“…The present report determined the frequency and the genetic diversity of NoVs in children up to three years of age, with acute gastroenteritis, living in the shantytowns of the city of Salvador, BA, in Northeast Brazil, and also determined RV-A and HAstV genotypes previously identified in these same stool samples (2).…”

Section: Discussionmentioning

confidence: 80%

“…The field studies have been described in detail elsewhere (2). In summary, participants were patients with diarrhea from a large longitudinal study in 21 areas of the city of Salvador, Northeast of Brazil, representing the city's poorer socioeconomic and sanitary conditions.…”

Section: Study Population and Sample Collectionmentioning

confidence: 99%

“…From July 24,2001 to January 31, 2002, 139 diarrheic stool samples were collected in the patient's household. All samples were previously tested for RV-A, HAstV and HAdV as described by Barreto et al (2). The present study was approved by the Ethics Research Committee of Instituto de Saúde Coletiva, Universidade Federal da Bahia, and all parents or persons responsible for the children gave written informed consent to participate.…”

Section: Study Population and Sample Collectionmentioning

confidence: 99%

“…Diarrheal diseases are a leading cause of morbidity and mortality worldwide and occur most often in children up to 5 years of age (1,2). Viral pathogens are the most common causes of gastroenteritis in communities and in other settings, including semi-closed institutions and hospitals.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, RV-A and HAstV were characterized to complement information from a previous study of the most common enteric pathogens present in children with acute gastroenteritis (2) and in order to determine the diversity of enteric viruses in these communities.…”

Section: Introductionmentioning

confidence: 99%

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Detection of caliciviruses associated with acute infantile gastroenteritis in Salvador, an urban center in Northeast Brazil

Xavier

Oliveira

Ferreira

et al. 2009

Braz J Med Biol Res

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Acute gastroenteritis caused by viruses is one of the leading causes of infantile morbidity. The aim of the present study was to investigate the presence of human caliciviruses of the genera norovirus and sapovirus in children up to 3 years of age with acute gastroenteritis from low-income communities in the city of Salvador, Brazil. This study is an extension of previous work carried out to establish the profile of the most prevalent enteric pathogens present in these communities. In this report, 139 fecal samples, collected from July 2001 to January 2002 were analyzed by RT-PCR and 13 (9%) were positive for human caliciviruses. By sequencing, seven isolates were characterized as norovirus genogroup GII and one as sapovirus genotype GII/1. Sequencing of the previously detected group-A rotaviruses and human astroviruses was also performed and revealed the circulation of rotavirus group A genotypes G1P[8] and G9P [8], and human astrovirus genotypes 6, 7, and 8. No mixed infection was observed. Community-based studies provide geographically representative information on disease burden. However, there are only a few reports in developing countries concerning the genotypes of the most important gastroenteric viruses detected in such communities. The present findings demonstrate the wide diversity of genotypes of the most important viruses responsible for acute gastroenteritis circulating in low-income communities.

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Section: Discussionmentioning

confidence: 80%

Section: Study Population and Sample Collectionmentioning

confidence: 99%

Section: Study Population and Sample Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Detection of caliciviruses associated with acute infantile gastroenteritis in Salvador, an urban center in Northeast Brazil

Xavier

Oliveira

Ferreira

et al. 2009

Braz J Med Biol Res

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Picobirnavirus infections: viral persistence and zoonotic potential

Ganesh

Bányai

Martella

et al. 2012

Reviews in Medical Virology

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Picobirnaviruses (PBVs) are small, non-enveloped, bisegmented double-stranded RNA genomic viruses of vertebrate hosts. Since their discovery in the late 1980s in clinical specimens from outbreaks of acute gastroenteritis in children, significant efforts have been made to investigate the role of PBV in diarrheic diseases. PBV has been detected in sporadic episodes of diarrhea as sole pathogen or coinfection as well as in outbreaks of acute gastroenteritis and in immunocompromised patients with diarrhea. However, PBV is frequently detected in non-diarrheic healthy hosts, and prolonged shedding has been observed in some individuals. Of interest, similar patterns of PBV infection have also been observed in pigs and other animal hosts. The increasing amount of PBV sequence data gathered from molecular epidemiological studies has evidenced a great sequence diversity of PBVs in various hosts and environmental samples. Importantly, evidence has been found for genetic relatedness between human and animal PBV strains, suggesting extant crossing points in the ecology and evolution of heterologous PBV strains. At present, no cell culture and animal model exists for PBVs. Well-structured epidemiological studies are still the only alternative to demonstrate the potential etiological role of PBVs in acute gastroenteritis or other diseases. This review aims to analyze the public health aspects of PBV infection, especially its possible association with zoonosis.

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Burden and typing of rotavirus group A in Latin America and the Caribbean: systematic review and meta‐analysis

Linhares

Stupka

Ciapponi

et al. 2011

Reviews in Medical Virology

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The efficacy of licensed rotavirus vaccines has only been shown against certain rotavirus group A (RV-A) types. It is critical to understand the burden of rotavirus gastroenteritis (RVGE) and its prevalent types to assess the potential impact of these vaccines in Latin America and the Caribbean (LA&C). We performed a systematic review and meta-analyses of all the available evidence reported from 1990 to 2009 on the burden of rotavirus disease and strains circulating in LA&C. Eligible studies--185 country-level reports, 174 951 faecal samples--were selected from MEDLINE, Cochrane Library, EMBASE, LILACS, regional Ministries of Health, PAHO, regional proceedings, doctoral theses, reference lists of included studies and consulting experts. Arc-sine transformations and DerSimonian-Laird random-effects model were used for meta-analyses. The proportion of gastroenteritis cases due to rotavirus was 24.3% (95%CI 22.3-26.4) and the incidence of RVGE was 170 per 1000 children-years (95%CI 130-210). We estimated a global annual mortality for 22 countries of 88.2 (95%CI 79.3-97.1) deaths per 100 000 under 5 years (47 000 deaths).The most common G type detected was G1 (34.2%), followed by G9 (14.6%), and G2 (14.4%). The most common P types detected were P[8] (56.2%), P[4] (22.1%) and P[1] 5.4%, and the most prevalent P-G type associations were P[8]G1 17.9%, P[4]G2 9.1% and P[8]G9 8.8%. In the last 10 years, G9 circulation increased remarkably and G5 almost disappeared. More recently, G12 appeared and P[4]G2 re-emerged. To our knowledge, this is the first meta-analysis of rotavirus infection and burden of disease in LA&C.

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Community-based monitoring of diarrhea in urban Brazilian children: incidence and associated pathogens

Cited by 38 publications

References 23 publications

Detection of caliciviruses associated with acute infantile gastroenteritis in Salvador, an urban center in Northeast Brazil

Detection of caliciviruses associated with acute infantile gastroenteritis in Salvador, an urban center in Northeast Brazil

Picobirnavirus infections: viral persistence and zoonotic potential

Burden and typing of rotavirus group A in Latin America and the Caribbean: systematic review and meta‐analysis

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