Community-Based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong

Ji, Liang; Liu, Li; Cheung, Mandy; Lee, Man‐Po; Wang, Haibo; Li, Chun-ho; Chan, Chun-Chung; Nishiura, Kenji; Tang, Xian; Tan, Zhiwu; Peng, Jie; Cheung, Kmc; Yam, Wing-Cheong; Chen, Zhiwei

doi:10.1371/journal.pone.0125715

Cited by 9 publications

(17 citation statements)

References 34 publications

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“…Of the eight studies that assessed strategies mobilizing MSM for AEHI testing, seven studies originated from well‐resourced settings [51,55‐59,61]. One study originated from a less‐resourced setting and was conducted in Thailand [60] (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Acute and early HIV infection screening among men who have sex with men, a systematic review and meta‐analysis

Palmer

Dijkstra

Ket

et al. 2020

J. Intern. AIDS Soc.

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Introduction: Screening for acute and early HIV infections (AEHI) among men who have sex with men (MSM) remains uncommon in sub-Saharan Africa (SSA). Yet, undiagnosed AEHI among MSM and subsequent failure to link to care are important drivers of the HIV epidemic. We conducted a systematic review and meta-analysis of AEHI yield among MSM mobilized for AEHI testing; and assessed which risk factors and/or symptoms could increase AEHI yield in MSM. Methods: We systematically searched four databases from their inception through May 2020 for studies reporting strategies of mobilizing MSM for testing and their AEHI yield, or risk and/or symptom scores targeting AEHI screening. AEHI yield was defined as the proportion of AEHI cases among the total number of visits. Study estimates for AEHI yield were pooled using random effects models. Predictive ability of risk and/or symptom scores was expressed as the area under the receiver operator curve (AUC). Results: Twenty-two studies were identified and included a variety of mobilization strategies (eight studies) and risk and/or symptom scores (fourteen studies). The overall pooled AEHI yield was 6.3% (95% CI, 2.1 to 12.4; I 2 = 94.9%; five studies); yield varied between studies using targeted strategies (11.1%; 95% CI, 5.9 to 17.6; I 2 = 83.8%; three studies) versus universal testing (1.6%; 95% CI, 0.8 to 2.4; two studies). The AUC of risk and/or symptom scores ranged from 0.69 to 0.89 in development study samples, and from 0.51 to 0.88 in validation study samples. AUC was the highest for scores including symptoms, such as diarrhoea, fever and fatigue. Key risk score variables were age, number of sexual partners, condomless receptive anal intercourse, sexual intercourse with a person living with HIV, a sexually transmitted infection, and illicit drug use. No studies were identified that assessed AEHI yield among MSM in SSA and risk and/or symptom scores developed among MSM in SSA lacked validation. Conclusions: Strategies mobilizing MSM for targeted AEHI testing resulted in substantially higher AEHI yields than universal AEHI testing. Targeted AEHI testing may be optimized using risk and/or symptom scores, especially if scores include symptoms. Studies assessing AEHI yield and validation of risk and/or symptom scores among MSM in SSA are urgently needed.

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Section: Resultsmentioning

confidence: 99%

Acute and early HIV infection screening among men who have sex with men, a systematic review and meta‐analysis

Palmer

Dijkstra

Ket

et al. 2020

J. Intern. AIDS Soc.

View full text Add to dashboard Cite

show abstract

“…As for information on sexual and non-sexual transmission disease respectively, most participants could answer the questions correctly, which meant that ceiling effects of knowledge acquisition may exist [60]. This may explain why most intervention methods emphasizing knowledge transferal have only had moderate success [10, 59, 61]. Additionally, the correlation between information and motivation was 0.553, while motivation had an indirect relationship with condom use behaviour through behavioural skills [40].…”

Section: Discussionmentioning

confidence: 99%

Assessing consistent condom use among migrant men who have sex with men in Shanghai, China: validation of an information–motivation–behavioural skills model

et al. 2019

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Background In China, high prevalence of risky sexual behaviours and inequity in health services lead to situations in which migrant men who have sex with men face higher risk of contracting the human immunodeficiency virus. Consistent condom use is a primary means of preventing HIV infection during anal sex among MSM. This study aimed to apply the information–motivation–behavioural skills model to examine the predictors of consistent condom use among migrant MSM in Shanghai, and tested the associations between model constructs. Methods A cross-sectional study was conducted among 412 migrant MSM in Shanghai. Data on HIV-related information, motivation, behavioural skills, and behaviours were collected via structured questionnaires. A structural equation model was used to assess the IMB model. Results Of the 412 participants, 4.4% reported HIV-positive status, and prevalence of consistent condom use in the previous 6 months was 44.9%. A restricted IMB model provided an acceptable fit to the data. Behavioural skills were found to directly predict consistent condom use (β = 0.629, P < 0.01). Neither information nor motivation could directly predict consistent condom use ( P > 0.05), but motivation predicted it indirectly and was mediated by behavioural skills. Conclusion The prevalence of consistent condom use was found to be relatively low among migrant MSM in Shanghai. The restricted IMB model was found to be a good predictor of consistent condom use among them. The results of this study indicate that intervention strategies for safer sexual behaviour should not only include information dissemination, but also emphasize motivation and behavioural skills among this population.

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“…Apart from syphilis infections, Chinese MSM who were having condomless anal sex also were at higher risk for HIV infection [15, 16]. Condomless sex prevailed among high school and college MSM students [17].…”

Section: Introductionmentioning

confidence: 99%

A spatiotemporal meta-analysis of HIV/syphilis epidemic among men who have sex with men living in mainland China

Zhao

et al. 2018

BMC Infect Dis

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BackgroundGeographic differences in HIV, syphilis and condomless sex among men who have sex with men in China remained unknown. We aimed to elucidate these spatiotemporal changing patterns in China.MethodsWe conducted a spatiotemporal meta-analysis. We searched four databases for studies conducted between 2001 and 2015. We included studies that reported original data of HIV/syphilis prevalence in China, the study’s area/province, and period of data collection. We grouped studies into six regions and four time periods. We examined the changing patterns of national and regional prevalence of HIV, syphilis and condomless sex.ResultsSearch results yielded 2119 papers, and 272 were included in the meta-analysis. The sample sizes of the studies ranged from 19 to 47,231. National HIV prevalence increased from 3.8% (95% CI 3.0–4.8) in 2001–07 to 6.6% (5.6–7.7) in 2013–15. In most regions, the rise occurred before 2010 and the HIV prevalence remained relatively stable afterwards, except for the Northwest which showed a considerable increase since 2008. National syphilis prevalence decreased from 12.3% (10.2–14.9) in 2001–07 to 7.1% (5.6–8.9) in 2013–15.ConclusionsThe trends of HIV and syphilis infections have been effectively curbed in MSM in most regions of China. Continuous efforts, particularly promotion of condom use, are needed to further reduce these infections.Electronic supplementary materialThe online version of this article (10.1186/s12879-018-3532-8) contains supplementary material, which is available to authorized users.

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Community-Based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong

Cited by 9 publications

References 34 publications

Acute and early HIV infection screening among men who have sex with men, a systematic review and meta‐analysis

Acute and early HIV infection screening among men who have sex with men, a systematic review and meta‐analysis

Assessing consistent condom use among migrant men who have sex with men in Shanghai, China: validation of an information–motivation–behavioural skills model

A spatiotemporal meta-analysis of HIV/syphilis epidemic among men who have sex with men living in mainland China

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