Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay

Pardo, Lorena; Vola, Magdalena; Macedo-Viñas, Marina; Machado, Virginia; Cuello, Dianna; Mollerach, Marta; Castro, Marta; Pírez, Catalina; Varela, Gustavo; Algorta, Gabriela

doi:10.3855/jidc.2261

Cited by 19 publications

(18 citation statements)

References 33 publications

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“…Estudios microbiológicos señalan que la gravedad de S. aureus no es una característica exclusiva de las cepas resistentes a meticilina, si bien éstas parecen poseer más atributos de virulencia, como la producción de una proteína de unión al colágeno (CNA) y de una exotoxina la leucocidina de PantonValantine que destruye los neutrófilos del hospedero generando inmunocompromiso y aumentando el riesgo de coagulopatía intravascular. Conduce además a la producción de material purulento más aglutinado, difícil de drenar y erradicar, por lo que el abordaje quirúrgico generalmente es más complejo y frecuente [36][37][38][39] . Las dos muertes se registraron también en este grupo etiológico.…”

Section: Discussionunclassified

Etiología y evolución de las infecciones osteo-articulares 2009-2015: Hospital Pediátrico del Centro Hospitalario Pereira Rossell, Uruguay

Zunino

Vomero

Pandolfo

et al. 2017

Rev. chil. infectol.

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Section: Discussionunclassified

Etiología y evolución de las infecciones osteo-articulares 2009-2015: Hospital Pediátrico del Centro Hospitalario Pereira Rossell, Uruguay

Zunino

Vomero

Pandolfo

et al. 2017

Rev. chil. infectol.

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“…Interestingly, the association between increased antibiotic resistance and decreased virulence has already been described for S. aureus (25) . Moreover, MRSA showed increased mortality rates compared with MSSA in several studies (26)(27)(28)(29) . However, little is known about the prognosis associated with MRSA ocular infections.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and antibiotic susceptibility of methicillin-resistant Staphylococcus aureus in ocular infections

Vola¹,

Moriyama²,

Lisboa³

et al. 2013

Arq. Bras. Oftalmol.

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Purpose: To study the prevalence of methicillin-resistant Staphylococcus aureus among S. aureus ocular infections in a tertiary health center in Brazil and compare antibiotic susceptibility patterns between MRSA and methicillin-susceptible S. aureus isolates. Methods: Electronic records from the ocular microbiology laboratory of the Universidade Federal de São Paulo were retrospectively reviewed. During a 10-year period (between January 2000 and December 2009) all conjunctivitis, keratitis, and endophthalmitis cases with a positive culture for S. aureus were identified. Antibiotic susceptibility was determined using the Kirby-Bauer disk diffusion method. Results: Five hundred sixty-six S. aureus isolates were identified; of those, 56 (9.9%) were resistant to methicillin. Throughout the 10-year period, Staphylococcus aureus showed a significant increasing trend from 7.55% to 16.18% among overall S. aurues infections (p=0.001) and from 3.7% to 13.16% in conjunctivitis (p=0.001). Conversely, we did not observe the same trend among those with keratitis (p=0.38). Staphylococcus aureus isolates showed higher resistance rates to tobramycin, gentamicin, ciprofloxacin, gatifloxacin, and moxifloxacin when compared with S. aureus isolates (p< 0.001). All cases were susceptible to vancomycin. Conclusion:We observed an increasing trend in the overall prevalence of Staphylococcus aureus ocular infections and statistically significant higher resistance rates to commonly used antibiotics compared to Staphylococcus aureus. Our data supports the need for constant bacterial surveillance and should be taken into consideration before initiating empiric treatment of ocular infections. Keywords

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“…However, it is believed that the smaller cassettes (particularly the IV) promote evolutionary advantages in spreading by horizontal transfer of this element, enabling the increase of CA-MRSA in hospitals 19 . Thus CA-MRSA SCC mec IV frequently show competitive advantages compared with multidrug-resistant strains (HA-MRSA) 20 . Several factors seem to contribute to these adaptive advantages of CA-MRSA isolates, such as the toxin PVL production 5, 19.…”

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confidence: 99%

Molecular characterization of methicillin-resistant Staphylococcus aureus isolated from blood in Rio de Janeiro displaying susceptibility profiles to non-β-lactam antibiotics

Zuma

Lima

Carvalho-Assef

et al. 2017

Brazilian Journal of Microbiology

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The distinction between healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) infections has become increasingly blurred. We assessed the molecular characterization and antimicrobial resistance profile for MRSA isolates from blood. Most of all (81.9%) isolates are related to known HA-MRSA and CA-MRSA epidemic lineages, such as, USA300, USA400, USA600, USA800 and USA1100. This is the first multicenter study in Rio de Janeiro.

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Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay

Abstract: CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genes.

Cited by 19 publications

References 33 publications

Etiología y evolución de las infecciones osteo-articulares 2009-2015: Hospital Pediátrico del Centro Hospitalario Pereira Rossell, Uruguay

Etiología y evolución de las infecciones osteo-articulares 2009-2015: Hospital Pediátrico del Centro Hospitalario Pereira Rossell, Uruguay

Prevalence and antibiotic susceptibility of methicillin-resistant Staphylococcus aureus in ocular infections

Molecular characterization of methicillin-resistant Staphylococcus aureus isolated from blood in Rio de Janeiro displaying susceptibility profiles to non-β-lactam antibiotics

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