Community-Associated Methicillin-Resistant<i>Staphylococcus aureus</i>, Iowa, USA

Griend, Philip Van De; Herwaldt, Loreen A.; Alvis, Bret; DeMartino, Mary; Heilmann, Kristopher P.; Doern, Gary V.; Winokur, Patricia L.; Vonstein, Diana DeSalvo; Diekema, Daniel J.

doi:10.3201/eid1510.080877

Cited by 38 publications

(37 citation statements)

References 35 publications

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“…This change in antimicrobial susceptibilities appeared to be associated with an increase in the proportion of CA-MRSA isolates identified in Canadian hospitals in the past 5 years (5,20). Communityassociated strains were generally more susceptible to antimicrobial agents and much less likely to be multidrug resistant than were HA-MRSA strains, as previously reported in recent U.S. studies (11,25). However, resistance is likely to increase in CA-MRSA strains, as they become prevalent in health care settings and become subject to increasing antimicrobial selection pressure (13).…”

supporting

confidence: 59%

Antimicrobial Susceptibilities of Health Care-Associated and Community-Associated Strains of Methicillin-Resistant Staphylococcus aureus from Hospitalized Patients in Canada, 1995 to 2008

Simor

Louie

Watt

et al. 2010

Antimicrob Agents Chemother

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We determined the in vitro antimicrobial susceptibilities of 7,942 methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained from patients hospitalized in 48 Canadian hospitals from 1995 to 2008. Regional variations in susceptibilities were identified. The dissemination of community-associated strains in Canada appears to have contributed to increased susceptibility of MRSA to several non-␤-lactam antimicrobial agents in the past decade. Reduced susceptibility to glycopeptides was not identified.

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supporting

confidence: 59%

Antimicrobial Susceptibilities of Health Care-Associated and Community-Associated Strains of Methicillin-Resistant Staphylococcus aureus from Hospitalized Patients in Canada, 1995 to 2008

Simor

Louie

Watt

et al. 2010

Antimicrob Agents Chemother

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“…Second, the studies in our meta-analyses are predominantly from cities, and they may not reflect the epidemiology of CA-MRSA in rural areas of the U.S., where a slower trajectory in the CA-MRSA epidemic has been reported [28]–[29]. However, it is worth noting that a surveillance study of ten microbiology laboratories in both rural and urban Minnesota in 1996–1998 [30] was consistent with the modeled curve shown for the Como-Sabetti et al study [21] in Figure 4.…”

Section: Resultsmentioning

confidence: 99%

Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus in the United States: A Meta-Analysis

et al. 2013

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Staphylococcus aureus is the most frequent cause of skin and soft tissue infections in humans. Methicillin-resistant strains of S. aureus (MRSA) that emerged in the 1960s presented a relatively limited public health threat until the 1990s, when novel community-associated (CA-) MRSA strains began circulating. CA-MRSA infections are now common, resulting in serious and sometimes fatal infections in otherwise healthy people. Although some have suggested that there is an epidemic of CA-MRSA in the U.S., the origins, extent, and geographic variability of CA-MRSA infections are not known. We present a meta-analysis of published studies that included trend data from a single site or region, and derive summary epidemic curves of CA-MRSA spread over time. Our analysis reveals a dramatic increase in infections over the past two decades, with CA-MRSA strains now endemic at unprecedented levels in many US regions. This increase has not been geographically homogeneous, and appears to have occurred earlier in children than adults.

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“…Furthermore, similar to the previous generations of phenylthiazoles, 4i appears to be bactericidal as its MBC values matched or were two-fold higher than its MIC values against both MRSA and VRSA (Table 1). This observation was confirmed using a standard time-kill assay against MRSA USA400, an invasive strain of community-associated MRSA that is a significant source of infection in North America[16] (Figure 2). Compound 4i retained its unique feature as a rapid bactericidal agent, compared to vancomycin, as it completely eliminated MRSA cells within four hours, while vancomycin required 24 hours to achieve the same effect (Figure 2), while the corresponding oxadiazole analogue behaves like vancomycin in its slow bactericidal action against MRSA.×.…”

Section: Resultsmentioning

confidence: 63%

Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis

Eid

Elsebaei

Mohammad

et al. 2017

European Journal of Medicinal Chemistry

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The promising antibacterial potency of arylthiazole antibiotics is offset by their limited activity against intracellular bacteria (namely methicillin-resistant Staphylococcus aureus (MRSA)), similar to many clinically-approved antibiotics. The failure to target these hidden pathogens is due to the compounds’ lack of proper characteristics to accumulate intracellularly. Fine tuning of the size and polar-surface-area of the linking heteroaromatic ring provided a new series of 5-thiazolylarylthiazoles with balanced properties that allow them to sufficiently cross and accumulate inside macrophages infected with MRSA. The most promising compound 4i exhibited rapid bactericidal activity, good metabolic stability and produced over 80% reduction of intracellular MRSA in infected macrophages.

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Community-Associated Methicillin-ResistantStaphylococcus aureus, Iowa, USA

Abstract: The proportion of invasive methicillin-resistant Staphylococcus aureus infections caused by USA300 increased in 2006.

Cited by 38 publications

References 35 publications

Antimicrobial Susceptibilities of Health Care-Associated and Community-Associated Strains of Methicillin-Resistant Staphylococcus aureus from Hospitalized Patients in Canada, 1995 to 2008

Antimicrobial Susceptibilities of Health Care-Associated and Community-Associated Strains of Methicillin-Resistant Staphylococcus aureus from Hospitalized Patients in Canada, 1995 to 2008

Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus in the United States: A Meta-Analysis

Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis

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