Community-acquired pneumonia: current data

Tsilogianni, Zoi; Grapatsas, Konstantinos; Vasileios, Leivaditis; Katsikogiannis, Nikolaos; Sarika, Eirini; Barbetakis, Nikolaos; Sarafis, Pavlos; Paliouras, Dimitrios; Karapantzos, Ιlias; Karapantzou, Chrysa; Trakada, Georgia; Bakakos, Petros

doi:10.21037/arh.2017.05.02

Cited by 3 publications

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“…Descriptive study, which involved hospitalized patients in the period between April and August 2017 with a coincident admission/discharge diagnosis of CAP based on established clinical, radiological, and pathological criteria (in the case of the deceased) [9][10][11]16,17]. Three different types of sample units were used: 208 blood cultures, 69 sputum examinations (cultures), and 8 samples of respiratory secretions and lung tissue, respectively, obtained postmortem.…”

Section: Methodsmentioning

confidence: 99%

“…In the specific case of our institution, the Hospital Dr Gustavo Adreima Lima in Cienfuegos, Cuba, the CAP is the first cause of admission to the Internal Medicine service, with figures that exceed a thousand annual admissions. Several guidelines and protocols for the diagnosis and treatment of patients with CAP include carrying out actions aimed at the etiological precision of the infectious process; for this purpose, various means are used, such as blood cultures, cultures of respiratory secretions obtained by expectoration and various serological tests, both in blood and urine [9][10][11][12][13][14]. Regardless of the usefulness that these complementary tests can provide, the delay in the information they provide and the need for early specific treatment in patients with pneumonia determine that antibiotic therapy in these patients, at the time of hospital admission, continues to be empirical; 2,3,5,10,13 in this sense, the guidelines and protocols are based on the existing epidemiological knowledge about the most frequent causes, both at the universal level and at the local level.…”

Section: Introductionmentioning

confidence: 99%

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Microbiological Isolates in Patients with Community-Acquired PNEUMONIA, COMPARATIVE STUDY of Three Methods

Martínez¹

2022

CJMI

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Introduction: Community-acquired pneumonia constitutes a major health problem worldwide.Objective: to determine the bacterial spectrum in patients hospitalized for pneumonia in a local context. Method:The results of 208 blood cultures, 69 sputum cultures, and 8 samples of respiratory secretions and lung tissue obtained postmortem were analyzed. The positivity index was determined for each method used, as well as the frequency of the isolated germs. Results:The positivity rate for respiratory secretions (postmortem) was 87.5%, lung tissue 75%, sputum 37.6%, and blood culture 10.6%. The isolates of Klebsiella pneumoniae (20) and Streptococcus pneumoniae (19) represented 64% of the total isolates. Conclusion: superiority of sputum culture over blood culture was verified in terms of probability of microbiological isolation. The importance of Streptococcus pneumoniae and Klebsiella pneumoniae as causes of community-acquired pneumonia was confirmed.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microbiological Isolates in Patients with Community-Acquired PNEUMONIA, COMPARATIVE STUDY of Three Methods

Martínez¹

2022

CJMI

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“…CAP is a common infectious disease that threatens human health. Epidemiological studies have shown that the mortality rate of hospitalized CAP patients is 4–14% worldwide ( 1 - 3 ). When pneumonia develops into severe pneumonia, in addition to causing abnormal responses of the respiratory system, it also damages other systems of the body, which may eventually induce acute respiratory distress syndrome, sepsis, and multiple organ damage ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Prediction of target genes in community-acquired pneumonia based on the bioinformatics method

Zuo¹,

Shen²,

Chen³

et al. 2023

J Thorac Dis

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Background To screen the related genes of community-acquired pneumonia (CAP) by bioinformatics technology, and to analyze the clinical value of key genes. Methods Gene chip data sets containing CAP patients and normal controls were screened from the Gene Expression Omnibus (GEO) database. The downregulated differentially expressed genes (DEGs) were screened using a gene expression analysis tool (GEO2R). Simultaneously, gene set enrichment analysis (GSEA) was used to explore the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and core genes related to CAP. The candidate genes were then intersected with the genes reported in Online Mendelian Inheritance in Man (OMIM), and the clinical value of these candidate genes was examined based on a literature search. Finally, the clinical data of the CAP patients were retrospectively analyzed. Detect the type of pathogenic bacteria in bronchial-alveolar lavage fluid (BALF) using metagenomics next-generation sequencing (mNGS) high throughput sequencing technology, and detect the expression of key genes through liquid based cell immunohistochemistry to analyze the correlation between pathogenic bacteria and key genes. Results Through the intersection of Venn diagrams, 175 co-expressed downregulated DEGs related to CAP were identified. A total of 4 candidate genes, including ICOS , IL7R , ITK , and ZAP70 , were obtained by constructing the protein mutual aid network and conducting a module analysis of the common differentially expressed genes. The core genes in the GSEA enrichment pathways were intersected with the CAP-related genes reported in the relevant literature retrieved from the OMIM database. In the Venn diagram, two genes that coexist with OMIM include IL7R and PIK3R1 . After considering our findings and the relevant literature, we determined that the key gene related to the occurrence and development of CAP was IL7R . The mNGS detected 13 kinds of bacteria, 4 kinds of fungi, and 2 kinds of viruses. Based on immunohistochemical results, it was found that there were relatively more bacteria detected in the IL7R high expression group. Conclusions The identification of the key gene IL7R and the related signaling pathways extend understanding of the pathogenesis of CAP and provide a theoretical basis for clinical targeted therapy research.

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Implicaciones del peso corporal de adultos mayores hospitalizados por neumonía adquirida en la comunidad en la capacidad para expectorar, gravedad al ingreso y letalidad

Corona-Martínez,

González-Morales,

Fragoso-Marchante

2022

NCT Neumología Y Cirugía De Tórax

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Community-acquired pneumonia: current data

Cited by 3 publications

References 0 publications

Microbiological Isolates in Patients with Community-Acquired PNEUMONIA, COMPARATIVE STUDY of Three Methods

Microbiological Isolates in Patients with Community-Acquired PNEUMONIA, COMPARATIVE STUDY of Three Methods

Prediction of target genes in community-acquired pneumonia based on the bioinformatics method

Implicaciones del peso corporal de adultos mayores hospitalizados por neumonía adquirida en la comunidad en la capacidad para expectorar, gravedad al ingreso y letalidad

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