Community-acquired pneumonia and survival of critically ill acute exacerbation of COPD patients in respiratory intensive care units

Takır, Hurıye Berk; Esquinas, António M.

doi:10.2147/copd.s124812

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…122 Similarly, in ICU patients with AECOPD þ CAP in-hospital mortality was higher than in AECOPD patients without CAP (42 vs. 33.3%). 62 However, this study did not report the ICU admission criteria for severe CAP, 123 which may have influenced patient mortality independent of the presence of CAP. 124…”

Section: Discussionmentioning

confidence: 94%

Pneumonic versus Nonpneumonic Exacerbations of Chronic Obstructive Pulmonary Disease

Crisafulli

Manco

Ferrer

et al. 2020

Semin Respir Crit Care Med

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Patients with chronic obstructive pulmonary disease (COPD) often suffer acute exacerbations (AECOPD) and community-acquired pneumonia (CAP), named nonpneumonic and pneumonic exacerbations of COPD, respectively. Abnormal host defense mechanisms may play a role in the specificity of the systemic inflammatory response. Given the association of this aspect to some biomarkers at admission (e.g., C-reactive protein), it can be used to help to discriminate AECOPD and CAP, especially in cases with doubtful infiltrates and advanced lung impairment. Fever, sputum purulence, chills, and pleuritic pain are typical clinical features of CAP in a patient with COPD, whereas isolated dyspnea at admission has been reported to predict AECOPD. Although CAP may have a worse outcome in terms of mortality (in hospital and short term), length of hospitalization, and early readmission rates, this has only been confirmed in a few prospective studies. There is a lack of methodologically sound research confirming the impact of severe AECOPD and COPD + CAP. Here, we review studies reporting head-to-head comparisons between AECOPD and CAP + COPD in hospitalized patients. We focus on the epidemiology, risk factors, systemic inflammatory response, clinical and microbiological characteristics, outcomes, and treatment approaches. Finally, we briefly discuss some proposals on how we should orient research in the future.

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Section: Discussionmentioning

confidence: 94%

Pneumonic versus Nonpneumonic Exacerbations of Chronic Obstructive Pulmonary Disease

Crisafulli

Manco

Ferrer

et al. 2020

Semin Respir Crit Care Med

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“…Pneumonia is one of the most common types of infections, and it is associated with high morbidity and mortality. The risk factors of pneumonia include smoking, recent viral respiratory tract infection, elderly patients, difficulty swallowing due to neurologic disease, immunocompromised status, recent trauma or trauma, heart diseases, and chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) [ 1 , 2 , 3 ]. To face this clinical entity, it is important to identify the population at high risk, such as vaccination for elderly and COPD patients.…”

Section: Introductionmentioning

confidence: 99%

Risks of Pneumonia in COPD Patients with New-Onset Atrial Fibrillation

Wang

Lai

Chen

et al. 2018

JCM

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The association between Atrial Fibrillation (AF) and pneumonia remains unclear. This study aims to assess the impact of AF on high pneumonia risk group—chronic obstructive pulmonary disease (COPD)—In order to find the association between AF and the risk of pneumonia. The COPD cohort was extracted from National Health Research Institute of Taiwan. The AF cohort comprised all COPD patients with new-onset AF (International Classification of Diseases (ICD)-9 code 427.31) after COPD diagnosis. We further sampled non-AF cohort and performed 1:1 propensity score matched analysis to improve the balance of baseline characteristics between AF and non-AF cohort. The outcomes were pneumonia and pneumonia requiring mechanical ventilation (MV). From 2000–2011, a total of 6228 patients with COPD and AF, and matched 84,106 control subjects were enrolled. After propensity score matching, we identified 6219 patients, each with AF, and matched controls without AF. After propensity score matching, the AF cohorts had higher risk of mortality (adjusted hazard ratio (aHR), 1.24; 95% confidence interval (CI), 1.15–1.34), pneumonia (aHR, 1.17; 95% CI, 1.07–1.27), and pneumonia requiring MV (aHR, 1.33; 95% CI, 1.18–1.50) in comparison with the matched non-AF cohort. After adjusting for mortality from causes other than outcomes of interest as a competing risk, AF remains significantly associated with pneumonia and pneumonia requiring MV. The risks of pneumonia were higher in this population with AF than in those without AF, and the risk was still significant after the adjustment for the competing risk of all-cause mortality.

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Patient-Reported Consequences of Community-Acquired Pneumonia in Patients with Chronic Obstructive Pulmonary Disease

et al. 2019

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Community-acquired pneumonia and survival of critically ill acute exacerbation of COPD patients in respiratory intensive care units

Cited by 3 publications

References 5 publications

Pneumonic versus Nonpneumonic Exacerbations of Chronic Obstructive Pulmonary Disease

Pneumonic versus Nonpneumonic Exacerbations of Chronic Obstructive Pulmonary Disease

Risks of Pneumonia in COPD Patients with New-Onset Atrial Fibrillation

Patient-Reported Consequences of Community-Acquired Pneumonia in Patients with Chronic Obstructive Pulmonary Disease

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